Stringent constraint on neutrino Lorentz-invariance violation from the two IceCube PeV neutrinos

It has been speculated that Lorentz-invariance violation (LIV) might be generated by quantum-gravity (QG) effects. As a consequence, particles may not travel at the universal speed of light. In particular, superluminal extragalactic neutrinos would rapidly lose energy via the bremssthralung of electron-positron pairs (nu -> nu e+ e-), damping their initial energy into electromagnetic cascades, a figure constrained by Fermi-LAT data. We show that the two cascade neutrino events with energies around 1 PeV recently detected by IceCube -if attributed to extragalactic diffuse events, as it appears likely- can place the strongest bound on LIV in the neutrino sector, namely delta =(v^2-1) ~ 10^(-4) M_Pl) for a linear (quadratic) LIV, at least for models inducing superluminal neutrino effects (delta > 0).Comment: 4 page

Turbulence patterns and neutrino flavor transitions in high-resolution supernova models

During the shock-wave propagation in a core-collapse supernova (SN), matter turbulence may affect neutrino flavor conversion probabilities. Such effects have been usually studied by adding parametrized small-scale random fluctuations (with arbitrary amplitude) on top of coarse, spherically symmetric matter density profiles. Recently, however, two-dimensional (2D) SN models have reached a space resolution high enough to directly trace anisotropic density profiles, down to scales smaller than the typical neutrino oscillation length. In this context, we analyze the statistical properties of a large set of SN matter density profiles obtained in a high-resolution 2D simulation, focusing on a post-bounce time (2 s) suited to study shock-wave effects on neutrino propagation on scales as small as O(100) km and possibly below. We clearly find the imprint of a broken (Kolmogorov-Kraichnan) power-law structure, as generically expected in 2D turbulence spectra. We then compute the flavor evolution of SN neutrinos along representative realizations of the turbulent matter density profiles, and observe no or modest damping of the neutrino crossing probabilities on their way through the shock wave. In order to check the effect of possibly unresolved fluctuations at scales below O(100) km, we also apply a randomization procedure anchored to the power spectrum calculated from the simulation, and find consistent results within \pm 1 sigma fluctuations. These results show the importance of anchoring turbulence effects on SN neutrinos to realistic, fine-grained SN models.Comment: 19 pages, 8 figures (Major changes in the text, references added, analysis and figures improved, main results unchanged. To appear in JCAP.

The strongest bounds on active-sterile neutrino mixing after Planck data

Light sterile neutrinos can be excited by oscillations with active neutrinos in the early universe. Their properties can be constrained by their contribution as extra-radiation, parameterized in terms of the effective number of neutrino species N_ eff, and to the universe energy density today \Omega_\nu h^2. Both these parameters have been measured to quite a good precision by the Planck satellite experiment. We use this result to update the bounds on the parameter space of (3+1) sterile neutrino scenarios, with an active-sterile neutrino mass squared splitting in the range (10^{-5} - 10^2 ) eV^2. We consider both normal and inverted mass orderings for the active and sterile states. For the first time we take into account the possibility of two non-vanishing active-sterile mixing angles. We find that the bounds are more stringent than those obtained in laboratory experiments. This leads to a strong tension with the short-baseline hints of light sterile neutrinos. In order to relieve this disagreement, modifications of the standard cosmological scenario, e.g. large primordial neutrino asymmetries, are required.Comment: v2 (9 pages, 10 eps figures) revised version. Discussion enlarged. Included bounds from the Planck limit on the sterile neutrino mass. References update

(Down-to-)Earth matter effect in supernova neutrinos

Neutrino oscillations in the Earth matter may introduce peculiar modulations in the supernova (SN) neutrino spectra. The detection of this effect has been proposed as diagnostic tool for the neutrino mass hierarchy at "large" 1-3 leptonic mixing angle theta13. We perform an updated study on the observability of this effect at large next-generation underground detectors (i.e., 0.4 Mton water Cherenkov, 50 kton scintillation and 100 kton liquid Argon detectors) based on neutrino fluxes from state-of-the-art SN simulations and accounting for statistical fluctuations via Montecarlo simulations. Since the average energies predicted by recent simulations are lower than previously expected and a tendency towards the equalization of the neutrino fluxes appears during the SN cooling phase, the detection of the Earth matter effect will be more challenging than expected from previous studies. We find that none of the proposed detectors shall be able to detect the Earth modulation for the neutrino signal of a typical galactic SN at 10 kpc. It should be observable in a 100 kton liquid Argon detector for a SN at few kpc and all three detectors would clearly see the Earth signature for very close-by stars only (d ~ 0.2 kpc). Finally, we show that adopting IceCube as co-detector together with a Mton water Cherenkov detector is not a viable option either.Comment: (14 pages, 5 ps figures

Electron anisotropy: A tool to discriminate dark matter in cosmic rays

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Dark matter electron anisotropy: a universal upper limit

We study the dipole anisotropy in the arrival directions of high energy CR electrons and positrons (CRE) of Dark Matter (DM) origin. We show that this quantity is very weakly model dependent and offers a viable criterion to discriminate among CRE from DM or from local discrete sources, like e.g. pulsars. In particular, we find that the maximum anisotropy which DM can provide is to a very good approximation a universal quantity and, as a consequence, if a larger anisotropy is detected, this would constitute a strong evidence for the presence of astrophysical local discrete CRE sources, whose anisotropy, instead, can be naturally larger than the DM upper limit. We further find that the main source of anisotropy from DM is given by the fluctuation in the number density of DM sub-structures in the vicinity of the observer and we thus devote special attention to the study of the variance in the sub-structures realization implementing a dedicated Montecarlo simulation. Such scenarios will be probed in the next years by Fermi-LAT, providing new hints, or constraints, about the nature of DM.Comment: 23 pages, 7 figure

Pseudomonas aeruginosa in a neonatal intensive care unit: molecular epidemiology and infection control measures

<p>Abstract</p> <p>Background</p> <p><it>Pseudomonas aeruginosa</it>, a non-fermentative, gram-negative rod, is responsible for a wide variety of clinical syndromes in NICU patients, including sepsis, pneumonia, meningitis, diarrhea, conjunctivitis and skin infections. An increased number of infections and colonisations by <it>P. aeruginosa </it>has been observed in the neonatal intensive care unit (NICU) of our university hospital between 2005 and 2007.</p> <p>Methods</p> <p>Hand disinfection compliance before and after an educational programme on hand hygiene was evaluated. Identification of microrganisms was performed using conventional methods. Antibiotic susceptibility was evaluated by MIC microdilution. Genotyping was performed by PFGE analysis.</p> <p>Results</p> <p>The molecular epidemiology of <it>Pseudomonas aeruginosa </it>in the NICU of the Federico II University hospital (Naples, Italy) and the infection control measures adopted to stop the spreading of <it>P. aeruginosa </it>in the ward were described. From July 2005 to June 2007, <it>P. aeruginosa </it>was isolated from 135 neonates and caused severe infections in 11 of them. Macrorestriction analysis of clinical isolates from 90 neonates identified 20 distinct genotypes, one major PFGE type (A) being isolated from 48 patients and responsible for 4 infections in 4 of them, four other distinct recurrent genotypes being isolated in 6 to 4 patients. Seven environmental strains were isolated from the hand of a nurse and from three sinks on two occasions, two of these showing PFGE profiles A and G identical to two clinical isolates responsible for infection. The successful control of the outbreak was achieved through implementation of active surveillance of healthcare-associated infections in the ward together with environmental microbiological sampling and an intense educational programme on hand disinfection among the staff members.</p> <p>Conclusion</p> <p><it>P. aeruginosa </it>infections in the NICU were caused by the cross-transmission of an epidemic clone in 4 neonates, and by the selection of sporadic clones in 7 others. An infection control programme that included active surveillance and strict adherence to hand disinfection policies was effective in controlling NICU-acquired infections and colonisations caused by <it>P. aeruginosa</it>.</p

Label-free fiber optic optrode for the detection of class C beta-lactamases expressed by drug resistant bacteria

This paper reports the experimental assessment of an automated optical assay based on label free optical fiber optrodes for the fast detection of class C beta-lactamases (AmpC BLs), actually considered as one of the most important sources of resistance to beta-lactams antibiotics expressed by resistant bacteria. Reflection-type long period fiber gratings (RT-LPG) have been used as highly sensitive label free optrodes, while a higher affine boronic acid based ligand was here selected to enhance the overall assay performances compared to those obtained in our first demonstration. In order to prove the feasibility analysis towards a fully automated optical assay, an engineered system was developed to simultaneously manipulate and interrogate multiple fiber optic optrodes in the different phases of the assay. The automated system tested in AmpC solutions at increasing concentrations demonstrated a limit of detection (LOD) of 6 nM, three times better when compared with the results obtained in our previous work. Moreover, the real effectiveness of the proposed optical assay has been also confirmed in complex matrices as the case of lysates of Escherichia coli overexpressing AmpC. (C) 2017 Optical Society of Americ

Effects of Magnetic Stimulation on Dental Implant Osseointegration: A Scoping Review

This PRISMA-ScR driven scoping review aims to evaluate the influence of magnetic field stimu-lation on dental implant osseointegration. Seven databases were screened adopting ad-hoc strings. All clinical and preclinical studies analyzing the effects of magnetic fields on dental im-plant osseointegration were included. From 3124 initial items, on the basis of the eligibility cri-teria, 33 articles, regarding both Pulsed ElectroMagnetic Fields (PEMF) and Static magnetic Fields from permanent Magnets (SFM) were finally included and critically analyzed. In vitro studies showed a positive effect of PEMF, but contrasting effects of SFM on bone cell proliferation, whereas cell adhesion and osteogenic differentiation were induced by both types of stimulation. In vivo studies showed an increased bone-to-implant contact rate in different animal models and clinical studies revealed positive effects on implant stability, under magnetic stimulation. In conclusion, although positive effects of magnetic exposure on osteogenesis activity and os-seointegration emerged, this scoping review highlighted the need for further preclinical and clinical studies. More standardized designs, accurate choice of stimulation parameters, adequate methods of evaluation of the outcomes, greater sample size and longer follow-ups are needed to clearly assess the effect of magnetic fields on dental implant osseointegration

Robust implications on Dark Matter from the first FERMI sky gamma map

We derive robust model-independent bounds on DM annihilations and decays from the first year of FERMI gamma-ray observations of the whole sky. These bounds only have a mild dependence on the DM density profile and allow the following DM interpretations of the PAMELA and FERMI electron/positron excesses: primary channels mu+ mu-, mu+ mu-mu+mu- or e+ e- e+ e-. An isothermal-like density profile is needed for annihilating DM. In all such cases, FERMI gamma spectra must contain a significant DM component, that may be probed in the future.Comment: 16 pages, 8 figures. Final versio