Exoplanet atmospheres with GIANO II. Detection of molecular absorption in the dayside spectrum of HD 102195b

The study of exoplanetary atmospheres is key to understand the differences between their physical, chemical and dynamical processes. Up to now, the bulk of atmospheric characterization analysis has been conducted on transiting planets. On some sufficiently bright targets, high-resolution spectroscopy (HRS) has also been successfully tested for non-transiting planets. We study the dayside of the non-transiting planet HD 102195b using the GIANO spectrograph mounted at TNG, demonstrating the feasibility of atmospheric characterization measurements and molecular detection for non-transiting planets with the HRS technique using 4-m class telescopes. The Doppler-shifted planetary signal changes on the order of many km/s during the observations, in contrast with the telluric absorption which is stationary in wavelength, allowing us to remove the contamination from telluric lines while preserving the features of the planetary spectrum. The emission signal from HD 102195b's atmosphere is then extracted by cross-correlating the residual spectra with atmospheric models. We detect molecular absorption from water vapor at 4.4$\sigma$ level. We also find convincing evidence for the presence of methane, which is detected at the 4.1$\sigma$ level. The two molecules are detected with a combined significance of 5.3$\sigma$, at a semi-amplitude of the planet radial velocity $K_P=128\pm 6$ km/s. We estimate a planet true mass of $M_P=0.46\pm 0.03~M_J$ and orbital inclination between 72.5 and 84.79$^{\circ}$ (1$\sigma$). Our analysis indicates a non-inverted atmosphere for HD 102195b, as expected given the relatively low temperature of the planet, inefficient to keep TiO/VO in gas phase. Moreover, a comparison with theoretical expectations and chemical model predictions corroborates our methane detection and suggests that the detected $CH_4$ and $H_2O$ signatures could be consistent with a low C/O ratio.Comment: 12 pages, 12 figures, accepted for publication in A&

Self-Injurious Behaviour in SCA17: A New Clinical Observation

Background: Self-injurious behaviour has historically been associated with borderline personality disorder. Nevertheless, over recent years, it has been reported in numerous neurological syndromes, especially hyperkinesias. Case report: Two cases of SCA17 manifested self-injurious behaviour, namely repetitive scratching of the skin resulting in severe excoriations. In one of them, the abnormal behaviour was associated with the inability to resist the impulse to commit the act along with relief following the damage. Discussion: This is the first report describing self-injurious behaviour in SCA17, but the mechanisms underlying it are still not clear. Further studies are needed to clarify the pathophysiology of such manifestation in hyperkinetic syndromes

Índice padronizado de precipitação aplicado às condições de seca no Estado do Espírito Santo.

O Índice Padronizado de Precipitação (SPI) é um dos métodos mais utilizados para quantificação da seca. A fim de verificar a possibilidade de utilização do SPI no monitoramento das deficiências e excessos de precipitação na escala mensal, no Estado do Espírito Santo objetivou-se, neste trabalho, verificar o ajuste das séries temporais dessa variável meteorológica à distribuição gama em cinco localidades do Estado. Por meio dos testes de aderência Kolmogorov-Smirnov e qui-quadrado, as séries mensais de precipitação pluvial das localidades sob análise podem ser consideradas oriundas de uma população com distribuição gama incompleta, permitindo o uso do SPI no monitoramento das condições de seca meteorológica. Através de análises de autocorrelação e correlação-cruzada, observou-se que a principal característica das séries do SPI é sua grande variabilidade espaço-temporal, a qual indica que em uma mesma região meses extremamente secos podem ser precedidos e/ou seguidos de meses úmidos ou normais, e que distintos casos de seca podem ocorrer de forma aleatória, entre as localidades e em um mesmo período

Exoplanet atmospheres with GIANO. I. Water in the transmission spectrum of HD 189733b

High-resolution spectroscopy (R $\ge$ 20,000) at near-infrared wavelengths can be used to investigate the composition, structure, and circulation patterns of exoplanet atmospheres. However, up to now it has been the exclusive dominion of the biggest telescope facilities on the ground, due to the large amount of photons necessary to measure a signal in high-dispersion spectra. Here we show that spectrographs with a novel design - in particular a large spectral range - can open exoplanet characterisation to smaller telescope facilities too. We aim to demonstrate the concept on a series of spectra of the exoplanet HD 189733 b taken at the Telescopio Nazionale Galileo with the near-infrared spectrograph GIANO during two transits of the planet. In contrast to absorption in the Earth's atmosphere (telluric absorption), the planet transmission spectrum shifts in radial velocity during transit due to the changing orbital motion of the planet. This allows us to remove the telluric spectrum while preserving the signal of the exoplanet. The latter is then extracted by cross-correlating the residual spectra with template models of the planet atmosphere computed through line-by-line radiative transfer calculations, and containing molecular absorption lines from water and methane. By combining the signal of many thousands of planet molecular lines, we confirm the presence of water vapour in the atmosphere of HD 189733 b at the 5.5-$\sigma$ level. This signal was measured only in the first of the two observing nights. By injecting and retrieving artificial signals, we show that the non-detection on the second night is likely due to an inferior quality of the data. The measured strength of the planet transmission spectrum is fully consistent with past CRIRES observations at the VLT, excluding a strong variability in the depth of molecular absorption lines.Comment: 10 pages, 8 figures. Accepted for publication in Astronomy & Astrophysics. v2 includes language editin

Clinical Evolution of New Delhi Metallo-β-Lactamase (NDM) optimizes resistance under Zn(II) Deprivation

Carbapenem-resistant Enterobacteriaceae (CRE) are rapidly spreading and taking a staggering toll on all health care systems, largely due to the dissemination of genes coding for potent carbapenemases. An important family of carbapenemases are the Zn(II)-dependent β-lactamases, known as metallo-β-lactamases (MBLs). Among them, the New Delhi metallo-β-lactamase (NDM) has experienced the fastest and widest geographical spread. While other clinically important MBLs are soluble periplasmic enzymes, NDMs are lipoproteins anchored to the outer membrane in Gram-negative bacteria. This unique cellular localization endows NDMs with enhanced stability upon the Zn(II) starvation elicited by the immune system response at the sites of infection. Since the first report of NDM-1, new allelic variants (16 in total) have been identified in clinical isolates differing by a limited number of substitutions. Here, we show that these variants have evolved by accumulating mutations that enhance their stability or the Zn(II) binding affinity in vivo, overriding the most common evolutionary pressure acting on catalytic efficiency. We identified the ubiquitous substitution M154L as responsible for improving the Zn(II) binding capabilities of the NDM variants. These results also reveal that Zn(II) deprivation imposes a strict constraint on the evolution of this MBL, overriding the most common pressures acting on catalytic performance, and shed light on possible inhibitory strategies.Fil: Bahr, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Vitor Horen, Luisina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Bethel, Christopher R.. Louis Stokes Cleveland VA Medical Center; Estados UnidosFil: Bonomo, Robert A.. Louis Stokes Cleveland VA Medical Center; Estados UnidosFil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentin