Anti-inflammatory effect of semisolid dosage forms containing capsaicin

Background: Capsaicin is alkaloid found primarily in the fruit of the Capsicum genus. Capsaicin and its analogues have been used in topical creams and patches to treat chronic pain and inflammation.Objectives: The paper deals with topical application of creams containing capsaicin to treat Freund’s adjuvant-induced inflammation.Materials and Methods: Anti-inflammatory activity was studied on the model adjuvantinduced inflammation with Freund's complete adjuvant. The study covered morphological changes in the inflamed area, the total number of white blood cells was studied by microscopic method in Gorjaev's chamber. The biochemical parameters of blood - cholinesterase activity and total number of alpha-1-acid glycoprotein in blood plasma were determined by the commercial test kits for rapid analysisResults: It was shown that the cream containing Capsicum annuum L. extract proved to be more efficient for treatment of adjuvant-induced inflammation than the commercial drug Dolgit Cream. Application of therapeutic cream with Capsicum annuum L. extract reduced activity of plasma acetylcholinesterase and total WBC count on the 15 day of treatment to initial values.Conclusion: The cream containing Capsicum annuum L. extract significantly inhibited inflammatory swelling, reduced WBC count and activity of plasma acetylcholinesterase.Keywords: capsaicin, ibuprophen, Freund’s adjuvant, inflammatio

Search of the radio emission from flare stars at decameter wavelengths

Observations of the two M-dwarf flare stars (AD Leonis and EV Lacertae), which were carried out with the radio telescope UTR-2 (Kharkiv, Ukraine) in the range of 16.5 − 33 MHz, are presented. 167 events of radio emission from AD Leo and 73 events from EV Lac were detected in the period of 2010-2011. These events were considered as stellar emission in ON-OFF regime of observations. The morphology of the probable events in the form of bursts from flare stars is considered and frequency drift rates, durations and uxes of the bursts are analysed

Theory, Politics... and History? Early post-war Soviet Control Engineering

A fascinating feature of post-war control engineering in the former Soviet Union was the rôle played by the study of the history of the discipline. Even before and during World War II some Soviet control scientists were actively researching the history of their subject; while after the war, historical studies played an important part both in technical developments and in legitimating a native Russian tradition. Two of the most important figures in this historical activity were A. A. Andronov and I. N. Voznesenskii, whose contributions are briefly considered

Decametric radio bursts associated with the 13 July 2004 CME event at frequencies 10–30 MHz

We report on the observations of solar type IV burst and its precursors on the 13 of July 2004 at frequencies 10 − 30 MHz. The radio telescope UTR-2 observational data compiled from SOHO, WIND, NDA, RHESSI, GOES data were used. The main properties (frequency drift rate, duration, flux) of type IV burst and its precursors, namely solar type III and type II bursts, are analysed. We consider the type IV burst connected with appearance of the coronal mass ejection, which occurrence coincides with the type IV burst beginning. Several physical characteristics of this CME were estimated

Frequency drift rates of powerful decameter Type III bursts

We report on the observations of powerful (fluxes are larger than 10⁻¹⁹ W m⁻² Hz⁻¹) solar Type III bursts at frequencies 10 − 30 MHz. Recordings of 163 bursts, observed in July 2002 and of 231 bursts observed in August 2002 are investigated. The main properties of these Type III bursts (frequency drift rate, duration, flux, frequency bandwidth) are analyzed. In present report we pay more attention to consideration of frequency drift rate. A great difference between the observed and the well-known empirical frequency dependencies of Type III bursts drift rate is determined. A linear approximation for the drift rate versus frequency is found. It indicates, that solar corona above active regions has exponential density distribution. We consider that drift rate value depends on the position of an active region on the solar disc

Accretion, Outflows, and Winds of Magnetized Stars

Many types of stars have strong magnetic fields that can dynamically influence the flow of circumstellar matter. In stars with accretion disks, the stellar magnetic field can truncate the inner disk and determine the paths that matter can take to flow onto the star. These paths are different in stars with different magnetospheres and periods of rotation. External field lines of the magnetosphere may inflate and produce favorable conditions for outflows from the disk-magnetosphere boundary. Outflows can be particularly strong in the propeller regime, wherein a star rotates more rapidly than the inner disk. Outflows may also form at the disk-magnetosphere boundary of slowly rotating stars, if the magnetosphere is compressed by the accreting matter. In isolated, strongly magnetized stars, the magnetic field can influence formation and/or propagation of stellar wind outflows. Winds from low-mass, solar-type stars may be either thermally or magnetically driven, while winds from massive, luminous O and B type stars are radiatively driven. In all of these cases, the magnetic field influences matter flow from the stars and determines many observational properties. In this chapter we review recent studies of accretion, outflows, and winds of magnetized stars with a focus on three main topics: (1) accretion onto magnetized stars; (2) outflows from the disk-magnetosphere boundary; and (3) winds from isolated massive magnetized stars. We show results obtained from global magnetohydrodynamic simulations and, in a number of cases compare global simulations with observations.Comment: 60 pages, 44 figure

Low background detector with enriched 116CdWO4 crystal scintillators to search for double beta decay of 116Cd

A cadmium tungstate crystal boule enriched in $^{116}$Cd to 82% with mass of 1868 g was grown by the low-thermal-gradient Czochralski technique. The isotopic composition of cadmium and the trace contamination of the crystal were estimated by High Resolution Inductively Coupled Plasma Mass-Spectrometry. The crystal scintillators produced from the boule were subjected to characterization that included measurements of transmittance and energy resolution. A low background scintillation detector with two $^{116}$CdWO$_4$ crystal scintillators (586 g and 589 g) was developed. The detector was running over 1727 h deep underground at the Gran Sasso National Laboratories of the INFN (Italy), which allowed to estimate the radioactive contamination of the enriched crystal scintillators. The radiopurity of a third $^{116}$CdWO$_4$ sample (326 g) was tested with the help of ultra-low background high purity germanium $\gamma$ detector. Monte Carlo simulations of double $\beta$ processes in $^{116}$Cd were used to estimate the sensitivity of an experiment to search for double $\beta$ decay of $^{116}$Cd.Comment: 24 pages, 13 figures, 3 tables, accepted for publication on Journal of Instrumentatio

Increase of the Integration Degree of Wind Power Plants into the Energy System Using Wind Forecasting and Power Consumption Predictor Models by Transmission System Operator

Wind power plants’ (WPPs) high penetration into the power system leads to various inconveniences in the work of system operators. This fact is associated with the unpredictable nature of wind speed and generated power, respectively. Due to these factors, such source of electricity must be connected to the power system to avoid detrimental effects on the stability and quality of electricity. The power generated by the WPPs is not regulated by the system operator. Accurate forecasting of wind speed and power, as well as power load can solve this problem, thereby making a significant contribution to improving the power supply systems reliability. The article presents a mathematical model for the wind speed prediction, which is based on autoregression and fuzzy logic derivation of Takagi-Sugeno. The new model of wavelet transform has been developed, which makes it possible to include unnecessary noise from the model, as well as to reveal the cycling of the processes and their trend. It has been proved, that the proposed combination of methods can be used simultaneously to predict the power consumption and the wind power plant potential power at any time interval, depending on the planning horizon. The proposed models support a new scientific concept for the predictive control system of wind power stations and increase their degree integration into the electric power system