436 research outputs found
Targeting tumor cell motility as a strategy against invasion and metastasis
Advances in diagnosis and treatment have rendered most solid tumors largely curable if they are diagnosed and treated before dissemination. However, once they spread beyond the initial primary location, these cancers are usually highly morbid, if not fatal. Thus, current efforts focus on both limiting initial dissemination and preventing secondary spread. There are two modes of tumor dissemination – invasion and metastasis – each leading to unique therapeutic challenges and likely to be driven by distinct mechanisms. However, these two forms of dissemination utilize some common strategies to accomplish movement from the primary tumor, establishment in an ectopic site, and survival therein. The adaptive behaviors of motile cancer cells provide an opening for therapeutic approaches if we understand the molecular, cellular, and tissue biology that underlie them. Herein, we review the signaling cascades and organ reactions that lead to dissemination, as these are non-genetic in nature, focusing on cell migration as the key to tumor progression. In this context, the cellular phenotype will also be discussed because the modes of migration are dictated by quantitative and physical aspects of the cell motility machinery.National Institute of General Medical Sciences (U.S.)National Cancer Institute (U.S.
An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction
There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus report.This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper.A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible.A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research
Repeated Randomization and Matching in Multi‐Arm Trials
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102047/1/biom12077.pd
Spin chirality on a two-dimensional frustrated lattice
The collective behavior of interacting magnetic moments can be strongly
influenced by the topology of the underlying lattice. In geometrically
frustrated spin systems, interesting chiral correlations may develop that are
related to the spin arrangement on triangular plaquettes. We report a study of
the spin chirality on a two-dimensional geometrically frustrated lattice. Our
new chemical synthesis methods allow us to produce large single crystal samples
of KFe3(OH)6(SO4)2, an ideal Kagome lattice antiferromagnet. Combined
thermodynamic and neutron scattering measurements reveal that the phase
transition to the ordered ground-state is unusual. At low temperatures,
application of a magnetic field induces a transition between states with
different non-trivial spin-textures.Comment: 7 pages, 4 figure
Neutron Scattering and Its Application to Strongly Correlated Systems
Neutron scattering is a powerful probe of strongly correlated systems. It can
directly detect common phenomena such as magnetic order, and can be used to
determine the coupling between magnetic moments through measurements of the
spin-wave dispersions. In the absence of magnetic order, one can detect diffuse
scattering and dynamic correlations. Neutrons are also sensitive to the
arrangement of atoms in a solid (crystal structure) and lattice dynamics
(phonons). In this chapter, we provide an introduction to neutrons and neutron
sources. The neutron scattering cross section is described and formulas are
given for nuclear diffraction, phonon scattering, magnetic diffraction, and
magnon scattering. As an experimental example, we describe measurements of
antiferromagnetic order, spin dynamics, and their evolution in the
La(2-x)Ba(x)CuO(4) family of high-temperature superconductors.Comment: 31 pages, chapter for "Strongly Correlated Systems: Experimental
Techniques", edited by A. Avella and F. Mancin
Human Case of Swine Influenza A (H1N1) Triple Reassortant Virus Infection, Wisconsin
Zoonotic infections with swine influenza A viruses are reported sporadically. Triple reassortant swine influenza viruses have been isolated from pigs in the United States since 1998. We report a human case of upper respiratory illness associated with swine influenza A (H1N1) triple reassortant virus infection that occurred during 2005 following exposure to freshly killed pigs
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