Bubble-resummation and critical-point methods for β\beta-functions at large NN

We investigate the connection between the bubble-resummation and critical-point methods for computing the $\beta$-functions in the limit of large number of flavours, $N$, and show that these can provide complementary information. While the methods are equivalent for single-coupling theories, for multi-coupling case the standard critical exponents are only sensitive to a combination of the independent pieces entering the $\beta$-functions, so that additional input or direct computation are needed to decipher this missing information. In particular, we evaluate the $\beta$-function for the quartic coupling in the Gross-Neveu-Yukawa model, thereby completing the full system at $\mathcal{O}(1/N)$. The corresponding critical exponents would imply a shrinking radius of convergence when $\mathcal{O}(1/N^2)$ terms are included, but our present result shows that the new singularity is actually present already at $\mathcal{O}(1/N)$, when the full system of $\beta$-functions is known.Comment: 11 pages, 7 figures; v2: references added, matches the published versio

Duality and Dimensional Reduction of 5D BF Theory

A planar boundary introduced \`a la Symanzik in the 5D topological BF theory, with the only requirement of locality and power counting, allows to uniquely determine a gauge invariant, non topological 4D Lagrangian. The boundary condition on the bulk fields is interpreted as a duality relation for the boundary fields, in analogy with the fermionization duality which holds in the 3D case. This suggests that the 4D degrees of freedom might be fermionic, although starting from a bosonic bulk theory. The method we propose to dimensionally reduce a Quantum Field Theory and to identify the resulting degrees of freedom can be applied to a generic spacetime dimension.Comment: 13 pages, plain LaTeX, version to appear on EPJ

Exaptive innovation in constraint-based environments: lessons from COVID-19 crisis

Purpose – This paper explores how exaptive innovation process might be considered a useful innovation model in constraint-based environments. Through an in-depth case study, it illustrates clearly the antecedents of exaptation processes, which are particularly relevant in rapidly changing environments requiring new solutions under time and resource constraints. Design/methodology/approach – The authors adopt a single case study approach that is particularly suitable in case of an inductive research design, which is required because of the novelty of the topic. The research is inspired by the use of the snorkeling mask EASYBREATH, commercialized by the giant Decathlon, as a medical device, a respirator to treat patients affected by coronavirus in Italy. The authors organized the evidence according to a novel taxonomy grounded in the literature. Findings – The case study stimulates reflections on the existence of some antecedents to the exaptive innovation process in constraint-based environments: (1) the availability of specific actors in the innovation process; (2) the creation of platforms of interaction between people with different competences, nurtured by collective bottom-up financing systems; (3) the role of the community of makers, in particular, and of the 4th industrial revolution, in general, for creating enabling technologies; (4) multidisciplinary individual background of key actors in the innovation process is crucial to ensure the exaptive path to be in place. Research limitations/implications – This work has some limitations, due to the choice of limiting the analysis to a single case, nevertheless, it offers a first glance on a new technological trajectory available in constraint-based environments. Originality/value – The case study results underline the importance of new digital collaboration platforms as knowledge multipliers, and illuminate on the potential of the fourth manufacturing revolution, which, through new technologies, creates opportunities for distributed forms of innovation that cross long distances

Gauging fractons and linearized gravity

We consider the covariant gauge field theory of fractons, which describe a new type of quasiparticles exhibiting novel and nontrivial properties. In particular, we focus on the field theoretical peculiarities which characterize this theory, starting from the fact that, if we accept the paradigm that quantum field theories are defined by their symmetries, fractons unavoidably come together with linearized gravity. The standard Faddeev-Popov procedure to gauge fix the theory leads to a scalar gauge condition, which has two important drawbacks: it is frozen in the Landau gauge and linearized gravity cannot be obtained as a limit. In this paper we adopt a tensorially alternative gauge fixing, which avoids both problems. In particular, this allows to show that important physical features, like the counting of the degrees of freedom, do not depend on a particular gauge choice, as expected. Moreover, the resulting gauge fixed theory contains both fractons and linearized gravity as a limit, differently from the standard scalar choice.Comment: 22 page

Reduction of Bacterial Proliferation by Zirconium Collar in Dental Implants

The peri-implant bacterial colonization is one of the current major problems facing dental implants with no actual protocols for prevention. The use of zirconium for bacterial eradication has already been reported and discussed in the dental literature. In this study we evaluated for the first time the ability of a "hybrid" dental implant model \u2013 where the implant collar is made out of titanium and zirconium - to reduce the peri-implant bacterial colonization, using traditional implants from the same manufacturer as controls. The results of microbiological analysis and the evaluation of the classic parameters of an implant success confirmed that, in all the 30 patients in this study, the zirconium collar had a vital role in reducing peri-implant bacterial colonization, and that the "hybrid" implants show lower plaque index values, less bleeding and less marginal bone loss than the traditional implants. Our data therefore suggest that a zirconium collar can effectively reduce the bacterial colonization around a titanium implant favoring a better long-term prognosis

Penetration of Sodium Hypochlorite Modified with Surfactants into Root Canal Dentin

Abstract The aim of this study was to evaluate the effect of concentration, exposure time and temperature of sodium hypochlorite (NaOCl) added with surfactants on its penetration into dentinal tubules. Sixty-five extracted human permanent maxillary anterior teeth with single canals were prepared by ProTaper SX hand-operated instruments. The teeth were then sectioned perpendicular to the long axis. The crowns and apical thirds of all the teeth were removed. The remaining roots were processed into 4-mm-long blocks and stained overnight in crystal violet. One hundred and thirty stained blocks were further split into halves and treated by nine different types of NaOCl-based solutions. Three solutions were added with surfactants (Hypoclean, H6, Chlor-Xtra) and the others were regular hypochlorites at increasing concentrations (1%, 2%, 4%, 5.25%, <6%, 6% NaOCl) from different brands. The dentin blocks were exposed to the solutions for 2, 5, and 20 min at 20 °C, 37 °C and 45 °C, respectively. The depth of NaOCl penetration was determined by bleaching of the stain and measured by light microscopy at 20 and 40. Statistical comparisons were made by using a generalized linear model with Bonferroni's post-hoc correction. The shortest penetration (81±6.6 μm) was obtained after incubation in 1% NaOCl for 2 min at 20 °C; the highest penetration (376.3±3.8 μm) was obtained with Chlor-Xtra for 20 min at 45 °C. Varying NaOCl concentration produced a minimal effect while temperature and exposure time had a significant direct relationship with NaOCl penetration into dentinal tubules, especially those with lowered surface tension. The exposure time and temperature of sodium hypochlorite as well as the addition of surfactants may influence the penetration depth of irrigants into dentinal tubules

The Propionibacterium spp. extract reduces Candida albicans-induced damage to vaginal epithelial cells and increases mitochondrial response to Candida albicans infection in vitro

Introduction. Bacterial lysates are prepared by inactivated microorganisms and are extensively employed in clinical settings as immunomodulants and to improve mucosal immunity. However, despite their extensive clinical use, their effects on the host are only partially known. The Propionibacterium spp. extract (PE) is a bacterial lysate included as an active compound in a gel formulation used to treat the symptoms of vulvovaginal candidiasis. Here, we analyzed its possible beneficial effects in an in vitro model of vaginal epithelial cells infected with Candida. Materials and Methods. Initially, we analyzed the PE effects on C. albicans and C. parapsilosis growth by the microdilution method. We then assessed the capacity of PE to reduce C. albicans-induced damage of vaginal epithelial cells through the quantification of lactate-dehydrogenase released by damaged cells in the growth medium. Moreover, in order to test the capacity of the PE to modulate epithelial mitochondrial activity, we evaluated Reactive-Oxygen-Species (ROS) production by the infected epithelial cells, stimulated or not with PE. This was kinetically monitored through the analysis of emitted fluorescence, after addition of the MitoSOX Red probe. Results. Our results show that PE did not affect directly microbial growth. In addition, the epithelial cells stimulation with PE reduced C. albicans-induced cell damage. Moreover, the treatment with PE increased the epithelial cells mitochondrial activity in response to C. albicans infection in vitro. Discussion and Conclusions. Taken together, our results show that PE increases ROS production by epithelial cells in response to C. albicans infection. Therefore, our results suggest that the increased mitochondrial activity induced by PE, could protect epithelial cells against the damage induced by C. albicans infection

The effect of degradation on the structural response of a reinforced concrete arch bridge

In recent years, several bridge collapses have occurred worldwide, resulting in human life and economic direct and non-direct losses. Such events are likely related to the age of bridges, which is approaching their lifespan in most of the cases. Furthermore, older bridges were designed according to outdated standards and built by using outdated materials and technologies, and consequently, require major retrofitting. Since infrastructures play a fundamental role in the road network, stakeholders and governance are committed to improve their performance with urgency. Structural safety assessment is fundamental to properly plan and identify maintenance interventions, also accounting for the effects of degradation phenomena. In fact, steel reinforcement corrosion, concrete cracking, creep and shrinkage severely affect expected lifespan of a structural system exposed to external environment and fatigue loads. In this paper, a review of the degradation models available in the literature is provided, discussing the influence of the main parameters on each degradation phenomenon. Subsequently, a numerical model of a case study Maillart’s bridge located in southern Italy is developed, implementing degradation effects to assess their influence on the structural performance. Since the bridge is located nearby the coast, both carbonation and chloride-induced corrosion of reinforcement were considered, as well as longterm physical effects on concrete mechanical behaviour. The results showed that material degradation may influence both local and global response of the structure and that predicting bridge behaviour evolution over time can be useful for its life cycle management

In vitro and ex vivo studies on the antibacterial efficacy of sodium hypochlorite and two new generation endodontic irrigants, Tetraclean® and MTAD, in comparison with sodium hypochlorite.

The aim of this work was to compare the efficacy of two endodontic iorrigants of new generation, Tetraclean and MTAD. Their antimicrobial effectiveness was assessed by in vitro and in vivo studies. Sodium hypochlorite was included as standard reference irrigant