19 research outputs found

    Finite element analysis of concrete-encased steel composite columns with off-center steel section

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    [EN] Concrete encased steel composite columns have been widely used in high-rise buildings and top-down constructions owning to excellent load-carrying capacity and fire resistance. However, double symmetric composite section is rarely achieved due to the off-center eccentricity of steel kingpost, which is a common problem in top-down constructions. EN1994-1-1 (EC4) simplified method does not provide any explicit provisions for this kind of irregular composite columns, and many designers address this issue by reducing it into a symmetrical cross-section for ease of simple calculation. This paper presents a general method based on nonlinear finite element modelling software ABAQUS to analyze the ultimate strength behavior of concrete-encased composite columns with asymmetrically placed steel section. The accuracy of the FE model is verified against existing test results. Parametric study is performed to further investigate the influence of steel section eccentricity on ultimate strength of stub columns under different loading conditions. A simplified method based on modification of EC4 design approach is developed to construct the moment-axial force interaction diagram. Accuracy of the proposed method is assessed by comparing the analytically predicted results with the numerical results. It is found that the proposed method can be adopted as a useful tool to predict the cross-section resistance of non-symmetrical concrete-encased steel composite columns.The research is funded by the Building & Construction Authority of Singapore under project grant R-302-000-168-409.Lai, B.; Liew, JY.; Li, S. (2018). Finite element analysis of concrete-encased steel composite columns with off-center steel section. En Proceedings of the 12th International Conference on Advances in Steel-Concrete Composite Structures. ASCCS 2018. Editorial Universitat Politècnica de València. 297-303. https://doi.org/10.4995/ASCCS2018.2018.7005OCS29730

    Top-Gate Transparent Organic Synaptic Transistors Based on Co-Mingled Heterojunctions

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    The rapid development of electronics and materials science has driven the progress of various electronic devices, and the new generation of electronic devices, represented by wearable smart products, has introduced transparent new demands on the devices. The ability of biological synapses to enhance or inhibit information when it is transmitted is thought to be the biological mechanism of artificial synaptic devices. The advantage of the human brain over conventional computers is the ability to perform efficient parallel operations when dealing with unstructured and complex problems. Inspired by biologically powerful neural networks, it is important to simulate biological synaptic functions on a single electronic device, and organic artificial synaptic transistors are artificially intelligent and very suitable artificial synaptic devices. Therefore, this paper proposes an organic artificial synaptic transistor with transparency (≥75%), provides a new solution for transparent top-gate synapses, and shows their promise for the next generation of organic electronics

    Triple Hybrid Cellular Nanovesicles Promote Cardiac Repair after Ischemic Reperfusion

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    The management of myocardial ischemia/reperfusion (I/R) damage in the context of reperfusion treatment remains a significant hurdle in the field of cardiovascular disorders. The injured lesions exhibit distinctive features, including abnormal accumulation of necrotic cells and subsequent inflammatory response, which further exacerbates the impairment of cardiac function. Here, we report genetically engineered hybrid nanovesicles (hNVs), which contain cell-derived nanovesicles overexpressing high-affinity SIRPα variants (SαV-NVs), exosomes (EXOs) derived from human mesenchymal stem cells (MSCs), and platelet-derived nanovesicles (PLT-NVs), to facilitate the necrotic cell clearance and inhibit the inflammatory responses. Mechanistically, the presence of SαV-NVs suppresses the CD47-SIRPα interaction, leading to the promotion of the macrophage phagocytosis of dead cells, while the component of EXOs aids in alleviating inflammatory responses. Moreover, the PLT-NVs endow hNVs with the capacity to evade immune surveillance and selectively target the infarcted area. In I/R mouse models, coadministration of SαV-NVs and EXOs showed a notable synergistic effect, leading to a significant enhancement in the left ventricular ejection fraction (LVEF) on day 21. These findings highlight that the hNVs possess the ability to alleviate myocardial inflammation, minimize infarct size, and improve cardiac function in I/R models, offering a simple, safe, and robust strategy in boosting cardiac repair after I/R

    CEPC Technical Design Report -- Accelerator

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    The Circular Electron Positron Collider (CEPC) is a large scientific project initiated and hosted by China, fostered through extensive collaboration with international partners. The complex comprises four accelerators: a 30 GeV Linac, a 1.1 GeV Damping Ring, a Booster capable of achieving energies up to 180 GeV, and a Collider operating at varying energy modes (Z, W, H, and ttbar). The Linac and Damping Ring are situated on the surface, while the Booster and Collider are housed in a 100 km circumference underground tunnel, strategically accommodating future expansion with provisions for a Super Proton Proton Collider (SPPC). The CEPC primarily serves as a Higgs factory. In its baseline design with synchrotron radiation (SR) power of 30 MW per beam, it can achieve a luminosity of 5e34 /cm^2/s^1, resulting in an integrated luminosity of 13 /ab for two interaction points over a decade, producing 2.6 million Higgs bosons. Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons, facilitating precise measurements of Higgs coupling at sub-percent levels, exceeding the precision expected from the HL-LHC by an order of magnitude. This Technical Design Report (TDR) follows the Preliminary Conceptual Design Report (Pre-CDR, 2015) and the Conceptual Design Report (CDR, 2018), comprehensively detailing the machine's layout and performance, physical design and analysis, technical systems design, R&D and prototyping efforts, and associated civil engineering aspects. Additionally, it includes a cost estimate and a preliminary construction timeline, establishing a framework for forthcoming engineering design phase and site selection procedures. Construction is anticipated to begin around 2027-2028, pending government approval, with an estimated duration of 8 years. The commencement of experiments could potentially initiate in the mid-2030s
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