74 research outputs found
The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage
- Author
- AE Kabakov
- AJ Massey
- Andrei L. Gartel
- BJ Weigel
- Christopher M. Nutting
- D Deckbar
- DM Moran
- EA Ronnen
- EE Bull
- EI Heath
- FA Dungey
- H Dote
- H Machida
- H Machida
- H Merwald
- J Schwock
- J Trepel
- JR Sydor
- JS Russell
- K Camphausen
- K Ha
- Kevin J. Harrington
- KS Bisht
- L Stingl
- LH Pearl
- LH Pearl
- M Castedo
- M Castedo
- M Lobrich
- M Noguchi
- Martin McLaughlin
- MR Jensen
- N Gaspar
- P Workman
- P Workman
- PA Brough
- Paul Workman
- PG Richardson
- Q Yao
- Robert A. Huddart
- S Pacey
- S Pacey
- SA Eccles
- Shane Zaidi
- Shreerang A. Bhide
- SJ Arlander
- SJ Arlander
- Suzanne A. Eccles
- T Oda
- T Stühmer
- TH Oude Munnink
- TT Koll
- U Banerji
- U Banerji
- V Gabai
- VL Gabai
- WB Nagengast
- X Yin
- Y Matsumoto
- Y Tao
- Publication venue
- Public Library of Science
- Publication date
- 16/04/2012
- Field of study
Heat shock protein 90 (HSP90) is a molecular chaperone responsible for the conformational maintenance of a number of client proteins that play key roles in cell cycle arrest, DNA damage repair and apoptosis following radiation. HSP90 inhibitors exhibit antitumor activity by modulating the stabilisation and activation of HSP90 client proteins. We sought to evaluate NVP-AUY922, the most potent HSP90 inhibitor yet reported, in preclinical radiosensitization studies.NVP-AUY922 potently radiosensitized cells in vitro at low nanomolar concentrations with a concurrent depletion of radioresistance-linked client proteins. Radiosensitization by NVP-AUY922 was verified for the first time in vivo in a human head and neck squamous cell carcinoma xenograft model in athymic mice, as measured by delayed tumor growth and increased surrogate end-point survival (p = <0.0001). NVP-AUY922 was shown to ubiquitously inhibit resolution of dsDNA damage repair correlating to delayed Rad51 foci formation in all cell lines tested. Additionally, NVP-AUY922 induced a stalled mitotic phenotype, in a cell line-dependent manner, in HeLa and HN5 cell lines irrespective of radiation exposure. Cell cycle analysis indicated that NVP-AUY922 induced aberrant mitotic entry in all cell lines tested in the presence of radiation-induced DNA damage due to ubiquitous CHK1 depletion, but resultant downstream cell cycle effects were cell line dependent.These results identify NVP-AUY922 as the most potent HSP90-mediated radiosensitizer yet reported in vitro, and for the first time validate it in a clinically relevant in vivo model. Mechanistic analysis at clinically achievable concentrations demonstrated that radiosensitization is mediated by the combinatorial inhibition of cell growth and survival pathways, ubiquitous delay in Rad51-mediated homologous recombination and CHK1-mediated G(2)/M arrest, but that the contribution of cell cycle perturbation to radiosensitization may be cell line specific
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
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- Alejo GC
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- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
- Jeon YD
- Jeong IY
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- Jeong WY
- Jeong WY
- Jian Z
- Jiao LR
- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
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- Kang Y
- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keep J
- Keep J
- Keller E
- Kellner F
- Kelly JM
- Kenardy J
- Keough E
- Kerhuel L
- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
- Kim HJ
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- Kim KS
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- Kim MH
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- Kim W
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- King HS
- Kinnear J
- Kirakli C
- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
- Kittnar O
- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
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- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
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- Kokkini S
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kovacikova L
- Kox M
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- Kristof J
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- Ku NS
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- Kubik M
- Kubota K
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- Kulaga EV
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- Kunze-Szikszay N
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- Kurth T
- Kurtz P
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- Kwon HM
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- Kye YC
- Kyle UG
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Latini R
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- Latorre J
- Lattuada M
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- Lau YH
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- Le Brocque R
- Lebherz-Eichinger D
- Lebiedz P
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- Lebut J
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- Letizia T
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- Li R
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- Lim TH
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- Lin KC
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- Lipcsey M
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- Lissonde F
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- Litchfield K
- Liu CP
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- Liu D
- Llaurado-Serra M
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- Lortat-Jacob B
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- Ly H
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- Macfarlane B
- MacKay A
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- Mackey G
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- Macrì M
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- Maekawa K
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- Maertens B
- Maggiorini M
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- Magnanimi E
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- Mainardi JL
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- Mezidi M
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- Mistry M
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- Stretti F
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- Toh CH
- Tokyo Womens Medical University
- Tomas E
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
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- Yamazaki A
- Yan WW
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- Yang JH
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- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
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- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Ackermann A
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
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- Akimov AV
- Akiyama D
- Akolkar NN
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- Alberghi GL
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- Albouy GL
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- Alegria ZL
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- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amirie KJ
- Amor Dos Santos SP
- Amos KR
- An S
- Ananiev V
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- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
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- Anthony MT
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- Aparisi Pozo JA
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- Burton CD
- Burzynski JC
- Busch EL
- Bussey PJ
- Butler JM
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- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabrera Urbán S
- Cadamuro L
- Caforio D
- Cai H
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- Cerqueira AS
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- Chapon E
- Chargeishvili B
- Charlton DG
- Chatterjee M
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- Chekulaev SV
- Chelkov GA
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- Chwastowski JJ
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- Ciesla KM
- Cindro V
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- Corpe LD
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- Cortes-Gonzalez A
- Costa MJ
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- Cueto A
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- Curcio F
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- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
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- Dao V
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- Dawson I
- Day-hall HA
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- De Maria A
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- Dell’Acqua A
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- Delmastro M
- Delsart PA
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- Demichev M
- Denisov SP
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- Derue F
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- Di Ciaccio A
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- Di Girolamo A
- Di Gregorio G
- Di Luca A
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- Xiong A
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- Yabsley B
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- Yamaguchi Y
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- Yeo BK
- Yexley MR
- Yin P
- Yorita K
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- Young C
- Young CJS
- Yu C
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- Zaazoua M
- Zabinski B
- Zaid E
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- Zhang DF
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- Zhang R
- Zhang S
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- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Modulators of axonal growth and guidance at the brain midline with special reference to glial heparan sulfate proteoglycans
- Author
- ANDERSON RB
- ANDERSON RB
- APKARIAN P
- ASHER RA
- BA-CHARVET KTN
- BAGRI A
- BANDTLOW CE
- BANSAL R
- BARNEA G
- BARRADAS PC
- BENNETT KL
- BERNHARDT RR
- BHIDE PG
- BOVOLENTA P
- BRADBURY EJ
- BRAET F
- BROSE K
- BRÜMMENDORF T
- BULLOCK SL
- BUTT HJ
- CASTELLANI V
- CHEN H
- CHITI F
- CHOI S
- CHUNG KY
- CHUNG KY
- COHEN NR
- COLAMARINO SA
- COLLINS VP
- DAHME M
- DODD J
- DOTTORI M
- DOU CJ
- DOW KE
- EASTER SS JR
- EMERLING DE
- ERSKINE L
- FAISSNER A
- FAZELI A
- FERNAUD-ESPINOSA I
- FIDLER PS
- FITCH MT
- FROST DO
- GARCIA-ABREU J
- GARCIA-ABREU J
- GARCIA-ABREU J
- GARCIA-ABREU J
- GARWOOD J
- GEORGE SE
- GILBERTO WEISSMÜLLER
- HALFTER W
- HAMRE KM
- HANTAZ-AMBROISE D
- HARROCH A
- HARTMANN U
- HENDERSON E
- HENKE-FAHLE S
- HENKEMEYER M
- HOFFMAN-KIM D
- HOLDER N
- HOPKER VH
- HU H
- ICHIJO H
- IMONDI R
- IMONDI R
- IOZZO RV
- IRIE A
- JHAVERI S
- JHAVERI S
- JHAVERI S
- JOSÉ GARCIA-ABREU
- KAGEYAMA GH
- KAHANE N
- KALIL K
- KAMIGUCHI H
- KAPPLER J
- KAPRIELIAN Z
- KINGSBURY BF
- KNÖLL B
- KULLANDER K
- KURT MA
- KUYPERS HGJM
- LANDER A
- LANDER AD
- LEFRANÇOIS T
- LENY A. CAVALCANTE
- LIANG Y
- LIESI P
- LIN X
- LIN X
- LITWACK ED
- LIU D
- LUCKENBILL-EDDS L
- LUIZ CLAUDIO SILVA
- LUSTIG M
- MARCUS RC
- MARCUS RC
- MARCUS RC
- MASON CA
- MAUREL P
- MCCABE CF
- MENDES F
- MENDEZ-OTERO R
- MENDEZ-OTERO R
- MEYER-PUTTLITZ B
- MILEV P
- MILEV P
- MING G-L
- MOON LGF
- MORI K
- NAKAGAWA S
- NIEDERÖST BP
- ONOFRE GR
- OOHIRA A
- ORIOLI D
- ORIOLI D
- ORLINO EN JR
- PARK S
- PARPURA V
- PIEPKORN M
- PIRES-NETO MA
- PLUMP AS
- POSTUMA RB
- PUELLES L
- RADMACHER M
- RAEDLER E
- RAPER JA
- RIOPELLE RJ
- RONCA F
- SAKURAI T
- SANDERSON RD
- SANTIAGO MF
- SCULLY AL
- SHIGA T
- SMITH VL
- SNOW AD
- SNOW DM
- SNOW DM
- SNOW DM
- SOMMER L
- SRETAVAN DW
- STOKER AW
- SUGA H
- SUN Q
- TALTS JF
- TAMADA A
- TAMAGNONE L
- TARDY M
- TESSIER-LAVIGNE M
- TIMPL R
- TOBEY SL
- TOIKKA J
- TRAN TS
- TURNBULL J
- VAN HARTESVELDT C
- VAN HORSSEN J
- VARELA-ECHAVARRIA A
- VERBEEK MM
- VERNA JM
- VIVALDO MOURA NETO
- WALZ A
- WANG LC
- WEISSMÜLLER G
- WEYN B
- WINKLER S
- WU D-Y
- YAMAGUCHI Y
- YAMANE Y
- YULIS CR
- YURCHENCO PD
- YURCHENCO PD
- YURCHENCO PD
- ZHOU FC
- ZHOU XH
- ZOU Y
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Possible Indications of Noradrenergic Involvement in Behavioral Plasticity
- Author
- A Björklund
- A Carlsson
- AK Mohammed
- BG Minor
- C. Post
- DC Davies
- DF Rose
- DH Hubel
- DL Hammond
- HB Katz
- HW Smith
- J Sagen
- JD Pettigrew
- L O’Shea
- MC Diamond
- MC Diamond
- MF Bear
- MR Rosenzweig
- PG Bhide
- PG Bhide
- RA Cummins
- T Archer
- T Archer
- T Archer
- T Archer
- T Archer
- T Archer
- T Archer
- T Archer
- T Archer
- T Kasamatsu
- T Kasamatsu
- T Kasamatsu
- TA Durkin
- TL Yaksh
- W Danysz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1988
- Field of study
Founder or Joiner? The Role of Preferences and Context in Shaping Different Entrepreneurial Interests
- Author
- Publication venue
- 'Institute for Operations Research and the Management Sciences (INFORMS)'
- Publication date
- Field of study
Phase Analysis by the Mössbauer Effect
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study
Effect of propylene carbonate as a plasticizer on (PEO)50AgCF3SO3:SnO2 nanocomposite polymer electrolyte
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Language-focused instruction for literacy acquisition in akshara-based languages: Pedagogical considerations and challenges
- Author
- A Bhide
- A Gupta
- A Saigal
- CS Hammer
- EA Poe
- Educational Initiatives
- FE Aboud
- G Arulmani
- H Aturupane
- H Winskel
- J Krishnamurti
- J Vaid
- K Jayaram
- K Kumar
- L Reese
- LS Vygotsky
- LT Verhoeven
- M Adams
- National Achievement Survey
- PG Patel
- R Amritavalli
- R Sen
- S Bhattacharjea
- S Menon
- S Nag
- S Nag
- S Nag
- S Nag
- S Nag
- S Nag
- S Nag
- Sonali Nag
- V Geetha
- V Kalia
- WH Teale
- Z Kurrien
- Publication venue
- Springer, Cham.
- Publication date
- 01/01/2019
- Field of study
In this chapter we explore the role of language- and meaning-focused instruction for supporting literacy acquisition in akshara-based languages, drawing upon examples from Hindi and the Devanagari script. Instruction of lower- and higher-level literacy skills typically targeted in pre- and primary school years are examined with a particular focus on the phonological, orthographic and morpho-syntactic domains. The role of affective-motivational aspects in learning and a strong cultural embedding of teaching-learning materials and pedagogical strategies are highlighted, with implications for native speakers and second language learners, in contexts of diglossia, and with demographically diverse groups. Such a multi-component curriculum is dependent on the perceptiveness and sensibilities of teachers, their attitudes towards teaching and learning, specific pedagogical skills and concrete knowledge-bases. We discuss the challenges this holds
Dopamine Receptor and Gα(olf) Expression in DYT1 Dystonia Mouse Models during Postnatal Development
- Author
- A Balcioglu
- A Granata
- A Sadnicka
- A Vasudevan
- A Vasudevan
- C Fiorentini
- D Herve
- Deirdre M. McCarthy
- DM McCarthy
- E Mengual
- F Yokoi
- F Yokoi
- F Yokoi
- G Sciamanna
- GA Keepers
- J Fuller
- J Hewett
- J Staedt
- J Zhu
- K Asanuma
- K Nishimura
- KY Araki
- L Belluscio
- L Zhang
- L Zhang
- Lin Zhang
- LJ Ozelius
- M Naumann
- MT Dang
- N Sharma
- Nutan Sharma
- PC Marrero-Gonzalez
- PG Bhide
- Pradeep G. Bhide
- S Cao
- S Fahn
- S Fahn
- SB Bressman
- SJ Augood
- SJ Augood
- SJ Augood
- SL Andersen
- SR Vemula
- T Fuchs
- TT Warner
- VA Boundy
- W Sako
- Xiaoxi Zhuang
- XO Breakefield
- XO Breakefield
- YI Chen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
- …