Design for an 8 Meter Monolithic UV/OIR Space Telescope

ATLAST-8 is an 8-meter monolithic UV/optical/NIR space observatory to be placed in orbit at Sun-Earth L2 by NASA's planned Ares V cargo launch vehicle. The ATLAST-8 will yield fundamental astronomical breakthroughs. The mission concept utilizes two enabling technologies: planned Ares-V launch vehicle (scheduled for 2019) and autonomous rendezvous and docking (AR&D). The unprecedented Ares-V payload and mass capacity enables the use of a massive, monolithic, thin-meniscus primary mirror - similar to a VLT or Subaru. Furthermore, it enables simple robust design rules to mitigate cost, schedule and performance risk. AR&D enables on-orbit servicing, extending mission life and enhancing science return

The Vehicle, June 1959, Vol. 1 no. 3

Vol. 1, No. 3 Table of Contents FrustrationNeil Parkerpage 3 Public FigureBert Browderpage 8 To a Young LadyNeil Parkerpage 8 Eastern -- YesterdayLinda Lyonspage 9 Glosing Won\u27t ServeD.E. Fullerpage 10 D. Linkwant at the BarD. Linkwantpage 10 The Wedgewood CupBarbara Wilson Dautpage 11 The SymptomsBert Browderpage 14 On a Charge for Over-DrawingD.E. Fullerpage 14 Information, PleaseD.E. Fullerpage 14 Query from Row Two, Seat ThreeHunkelheimerpage 15 DeceptionBarbara Wilson Dautpage 15 Binge in Mind?Anon.page 15 A CommaJean Nightingalepage 16 Miss Me, Kate!A.B. Carterpage 16 My SinsJean Nightingalepage 16https://thekeep.eiu.edu/vehicle/1002/thumbnail.jp

The Vehicle, June 1959, Vol. 1 no. 3

Vol. 1, No. 3 Table of Contents FrustrationNeil Parkerpage 3 Public FigureBert Browderpage 8 To a Young LadyNeil Parkerpage 8 Eastern -- YesterdayLinda Lyonspage 9 Glosing Won\u27t ServeD.E. Fullerpage 10 D. Linkwant at the BarD. Linkwantpage 10 The Wedgewood CupBarbara Wilson Dautpage 11 The SymptomsBert Browderpage 14 On a Charge for Over-DrawingD.E. Fullerpage 14 Information, PleaseD.E. Fullerpage 14 Query from Row Two, Seat ThreeHunkelheimerpage 15 DeceptionBarbara Wilson Dautpage 15 Binge in Mind?Anon.page 15 A CommaJean Nightingalepage 16 Miss Me, Kate!A.B. Carterpage 16 My SinsJean Nightingalepage 16https://thekeep.eiu.edu/vehicle/1002/thumbnail.jp

Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery

Our understanding of the intracrine (or local) regulation of estrogen and other steroid synthesis and degradation expanded in the last decades, also thanks to recent technological advances in chromatography mass-spectrometry. Estrogen responsive tissues and organs are not passive receivers of the pool of steroids present in the blood but they can actively modify the intra-tissue steroid concentrations. This allows fine-tuning the exposure of responsive tissues and organs to estrogens and other steroids in order to best respond to the physiological needs of each specific organ. Deviations in such intracrine control can lead to unbalanced steroid hormone exposure and disturbances. Through a systematic bibliographic search on the expression of the intracrine enzymes in various tissues, this review gives an up-to-date view of the intracrine estrogen metabolisms, and to a lesser extent that of progestogens and androgens, in the lower female genital tract, including the physiological control of endometrial functions, receptivity, menopausal status and related pathological conditions. An overview of the intracrine regulation in extra gynecological tissues such as the lungs, gastrointestinal tract, brain, colon and bone is given. Current therapeutic approaches aimed at interfering with these metabolisms and future perspectives are discussed

An online international comparison of palliative care identification in primary care using the Surprise Question.

BACKGROUND The Surprise Question ('Would I be surprised if this patient died within 12 months?') identifies patients in the last year of life. It is unclear if 'surprised' means the same for each clinician, and whether their responses are internally consistent. AIM To determine the consistency with which the Surprise Question is used. DESIGN A cross-sectional online study of participants located in Belgium, Germany, Italy, The Netherlands, Switzerland and UK. Participants completed 20 hypothetical patient summaries ('vignettes'). Primary outcome measure: continuous estimate of probability of death within 12 months (0% [certain survival]-100% [certain death]). A threshold (probability estimate above which Surprise Question responses were consistently 'no') and an inconsistency range (range of probability estimates where respondents vacillated between responses) were calculated. Univariable and multivariable linear regression explored differences in consistency. Trial registration: NCT03697213. SETTING/PARTICIPANTS Registered General Practitioners (GPs). Of the 307 GPs who started the study, 250 completed 15 or more vignettes. RESULTS Participants had a consistency threshold of 49.8% (SD 22.7) and inconsistency range of 17% (SD 22.4). Italy had a significantly higher threshold than other countries (p = 0.002). There was also a difference in threshold levels depending on age of clinician, for every yearly increase, participants had a higher threshold. There was no difference in inconsistency between countries (p = 0.53). CONCLUSIONS There is variation between clinicians regarding the use of the Surprise Question. Over half of GPs were not internally consistent in their responses to the Surprise Question. Future research with standardised terms and real patients is warranted

Generation of 3 spinocerebellar ataxia type 1 (SCA1) patient-derived induced pluripotent stem cell lines LUMCi002-A, B, and C and 2 unaffected sibling control induced pluripotent stem cell lines LUMCi003-A and B

Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease caused by a CAG repeat expansion in exon 8 of the ATXN1 gene. We generated induced pluripotent stem cells (hiPSCs) from a SCA1 patient and his non-affected sister by using non-integrating Sendai Viruses (SeV). The resulting hiPSCs are SeVfree, express pluripotency markers, display a normal karyotype, retain the mutation (length of the CAG repeat expansion in the ATXN1 gene) and are able to differentiate into the three germ layers in vitro

ATLAST-8 Mission Concept Study for 8-Meter Monolithic UV/Optical Space Telescope

ATLAST-8m is an 8-meter monolithic UV/optical/NIR space observatory which could be placed in orbit at Sun-Earth L2 by a heavily lift launch vehicle. Two development study cycles have resulted in a detailed concept including a dual foci optical design; several primary mirror launch support and secondary mirror support structural designs; spacecraft propulsion, power and pointing control design; and thermal design. ATLAST-8m is designed to yield never before achieved performance to obtain fundamental astronomical breakthrough