14,101 research outputs found
Extended Gas in Seyfert Galaxies: Near Infrared Observations of NGC 2110 and Circinus
We present results of near--IR long-slit spectroscopy in the J and K bands of
the Seyfert 2 galaxies NGC 2110 and Circinus, investigating the gaseous
distribution, excitation, reddening and kinematics. In NGC 2110, the emission
line ratio [FeII]/Pa beta increases towards the nucleus (to ~ 7). The nuclear
[Fe II]1.257 (microns) and Pa beta lines are broader (FWHM ~ 500 km/s) than the
H2 (2.121) line (FWHM ~ 300 km/s). Both these results suggest that shocks,
driven by the radio jet, are an important source of excitation of [Fe II]. The
H2 excitation appears to be dominated by X-rays from the nucleus. In Circinus,
both [FeII]/Pa beta and H2/Br gamma decrease from ~ 2 at 4 arcsec from the
nucleus to nuclear values of ~ 0.6 and ~ 1, respectively, suggesting that the
starburst dominates the nuclear excitation, while the AGN dominates the
excitation further out (r > 2 arcsec). For both galaxies, the gaseous
kinematics are consistent with circular rotation in the plane of the disk. Our
rotation curves suggest that the nucleus (identified with the peak of the IR
continuum) is displaced from the kinematic centre of the galaxies. This effect
has been observed previously in NGC 2110 based on the kinematics of optical
emission lines, but the displacement is smaller in the infrared, suggesting the
effect is related to obscuration. The continuum J-K colours of the nuclear
region indicate a red stellar population in NGC 2110 and a reddened young
stellar population in Circinus. Right at the nucleus of both galaxies, the
colours are redder, apparently a result of hot dust emission from the inner
edge of a circumnuclear torus.Comment: 11 pages, 14 figures, accepted for publication in MNRA
Complementarity relation for irreversible process derived from stochastic energetics
When the process of a system in contact with a heat bath is described by
classical Langevin equation, the method of stochastic energetics [K. Sekimoto,
J. Phys. Soc. Jpn. vol. 66 (1997) p.1234] enables to derive the form of
Helmholtz free energy and the dissipation function of the system. We prove that
the irreversible heat Q_irr and the time lapse $Delta t} of an isothermal
process obey the complementarity relation, Q_irr {Delta t} >= k_B T S_min,
where S_min depends on the initial and the final values of the control
parameters, but it does not depend on the pathway between these values.Comment: 3 pages. LaTeX with 6 style macro
Gravitational Chern-Simons and the adiabatic limit
We compute the gravitational Chern-Simons term explicitly for an adiabatic
family of metrics using standard methods in general relativity. We use the fact
that our base three-manifold is a quasi-regular K-contact manifold heavily in
this computation. Our key observation is that this geometric assumption
corresponds exactly to a Kaluza-Klein Ansatz for the metric tensor on our three
manifold, which allows us to translate our problem into the language of general
relativity. Similar computations have been performed in a paper of Guralnik,
Iorio, Jackiw and Pi (2003), although not in the adiabatic context.Comment: 17 page
Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas
BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases (RTKs) and members of the fibroblast growth factor receptors (FGFR)-family. Single-nucleotide polymorphism (SNP) Arg388 of the FGFR4 is associated with a reduced overall survival in patients with cancers of various types. We speculate that FGFR4 expression and SNP is associated with worse survival in patients with HSNCC. AIM To investigate the potential clinical significance of FGFR4 Arg388 in the context of tumors arising in HNSCC, a comprehensive analysis of FGFR4 receptor expression and genotype in tumor tissues and correlated results with patients' clinical data in a large cohort of patients with HNSCC was conducted. METHODS Surgical specimens from 284 patients with HNSCC were retrieved from the Institute of Pathology at the Ludwig-Maximilian-University in Germany. Specimens were analyzed using immunohistochemistry and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The expression of FGFR4 was analyzed in 284 surgical specimens of HNSCC using immunohistochemstry. FGFR4 polymorphism was detected by PCR-RFLP. Patients' clinical data with a minimum follow-up of 5 syears were statistically evaluated with a special emphasis on survival analysis employing Kaplan-Meier estimator and Cox regression analysis. RESULTS Concerning the invasive tumor areas the intensity of the FGFR4 expression was evaluated in a four-grade system: no expression, low expression, intermediate and high expression. FGFR4 expression was scored as "high" (+++) in 74 (26%), "intermediate" (++) in 103 (36.3%), and "low" (+) in 107 (36.7%) cases. Analyzing the FGFR4 mutation it was found in 96 tumors (33.8%), 84 of them (29.6%) having a heterozygous and 12 (4.2%) homozygous mutated Arg388 allele. The overall frequency concerning the mutant alleles demonstrated 65% vs 34% mutated alleles in general. FGFR4 Arg388 was significantly associated with advanced tumor stage (P < 0.004), local metastasis (P < 0.0001) and reduced disease-free survival (P < 0.01). Furthermore, increased expression of FGFR4 correlated significantly with worse overall survival (P < 0.003). CONCLUSION In conclusion, the FGFR4 Arg388 genotype and protein expression of FGFR4 impacts tumor progression in patients with HNSCC and may present a useful target within a multimodal therapeutic intervention
ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
European Innovation Partnership on Active and Healthy Ageing Reference Site MACVIA-France, EU Structural and Development Fund Languedoc-Roussillon, ARIA.Peer reviewedPublisher PD
Environmental influences on infantsâ native vowel discrimination: The case of talker number in daily life
Both quality and quantity of speech from the primary caregiver have been found to impact language development. A third aspect of the input has been largely ignored: the number of talkers who provide input. Some infants spend most of their waking time with only one person; others hear many different talkers. Even if the very same words are spoken the same number of times, the pronunciations can be more variable when several talkers pronounce them. Is language acquisition affected by the number of people who provide input? To shed light on the possible link between how many people provide input in daily life and infantsâ native vowel discrimination, three age groups were tested: 4-month-olds (before attunement to native vowels), 6-month-olds (at the cusp of native vowel attunement) and 12-month-olds (well attuned to the native vowel system). No relationship was found between talker number and native vowel discrimination skills in 4- and 6-month-olds, who are overall able to discriminate the vowel contrast. At 12 months, we observe a small positive relationship, but further analyses reveal that the data are also compatible with the null hypothesis of no relationship. Implications in the context of infant language acquisition and cognitive development are discussed
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Revisiting and revitalizing political ecology in the American West
Political ecology, initially conceived to better understand the power relations implicit in management and distribution of natural resources in the developing world, came âhomeâ to the American West in the 1990s and 2000s. This groundswell of research did much to problematize socio-environmental conflicts in the region, long typified by tensions over land and resources, identity and belonging, autonomy and authority. Since first touching down in the West, however, the âbig tentâ of political ecology has only grown bigger, incorporating new perspectives, epistemologies, and ontologies. At the same time, the nexus of environment and society is perhaps even more salient today, amid a regional conjuncture of populist revolt, climate change, and rapid political economic transformation. Here we reflect on three longstanding regional concerns â energy development, wolf reintroduction, and participatory governance â leveraging the pluralism of contemporary political ecology to better understand their contemporary incarnations. In so doing, we highlight the need to bring together insights from both âtraditionalâ approaches and newer directions to better understand and engage contemporary challenges, with their heightened stakes and complexity. Such an approach demonstrates what we might learn about global processes in this place, as well as what insights regional praxis (often woefully provincial) might gain from elsewhere â new ways of seeing and doing political ecology. Our goal is to generate discussion among and between political ecologists and regional critical scholars, initiating new collaborative engagements that might serve the next wave of political ecology in the 21st century American West
Reparameterization invariants for anisotropic Bianchi I cosmology with a massless scalar source
Intrinsic time-dependent invariants are constructed for classical, flat,
homogeneous, anisotropic cosmology with a massless scalar material source.
Invariance under the time reparameterization-induced canonical symmetry group
is displayed explicitly.Comment: 28 pages, to appear in General Relativity and Gravitation.
Substantial revisions: added foundational overview section 2, chose new
intrinsic time variable, worked with dimensionless variables, added appendix
with comparison and criticism of other approache
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