Environmental impacts of reusable transport items: A case study of pallet pooling in a retailer supply chain

Manufacturing, storage, and transportation processes are typically facilitated by pallets, containers, and other reusable transport items (RTIs) designed to guarantee many cycles along a lifespan of several years. As a consequence, both supply and reverse transportation of RTIs need to be managed to avoid stockout along the supply chain and the unsustainable production of new tools from virgin materials. This paper focuses on the business of pallet management by analyzing the transport operations of a pallet pooling network serving a large-scale nationwide retailer. The pooler is responsible for supplying, collecting, and refurbishing pallets. The combination of the pooler's management strategies with different retailer network configurations results in different pooling scenarios, which are assessed and compared in this paper through a what-if analysis. The logistical and environmental impacts generated by the pallet distribution activities are quantified per each scenario through a tailored software incorporating Geographic Information System (GIS) and routing functionalities. Findings from this analysis suggest how to reduce vehicle distance traveled (vehicles-km) by 65% and pollutant emissions by 60% by combining network infrastructures and pooling management strategies-identifying an empirical best practice for managers of pallet businesses

Environmental impacts of reusable transport items: A case study of pallet pooling in a retailer supply chain

Manufacturing, storage, and transportation processes are typically facilitated by pallets, containers, and other reusable transport items (RTIs) designed to guarantee many cycles along a lifespan of several years. As a consequence, both supply and reverse transportation of RTIs need to be managed to avoid stockout along the supply chain and the unsustainable production of new tools from virgin materials. This paper focuses on the business of pallet management by analyzing the transport operations of a pallet pooling network serving a large-scale nationwide retailer. The pooler is responsible for supplying, collecting, and refurbishing pallets. The combination of the pooler's management strategies with different retailer network configurations results in different pooling scenarios, which are assessed and compared in this paper through a what-if analysis. The logistical and environmental impacts generated by the pallet distribution activities are quantified per each scenario through a tailored software incorporating Geographic Information System (GIS) and routing functionalities. Findings from this analysis suggest how to reduce vehicle distance traveled (vehicles-km) by 65% and pollutant emissions by 60% by combining network infrastructures and pooling management strategies-identifying an empirical best practice for managers of pallet businesses

A Data Architecture to aid Life Cycle Assessment in closed-loop Reusable Plastic Container networks

Abstract Returnable container networks have caught the eye of those companies that aim to reduce waste generation and environmental impact. The literature already includes studies on the environmental impact (i.e. Life Cycle Assessment, LCA) of these networks. However, the major part is based on secondary data since the collection of primary data is complex and time-intensive. This paper proposes an object-relational database dedicated to the storage of data from a closed-loop reusable plastic crates (RPC) networks for fruits and vegetables. The goal is supporting scholars and managers during the LCA through a user-friendly data architecture, while suggesting structured guidelines for the primary data collection. Each node of the RPC network is characterized by a similar set of entity types, such as machines, which allows to process the RPCs with respect to specific cycles. Each entity, process and cycle are therefore reflected in the database by objects that are connected with relations

Evaluation of Common Bean Varieties for Yield and Yield Component in Segen Area Peoples Zone SNNPRS, Ethiopia

Studies on the evaluation of variety performance provide opportunities to increase productivity of common bean. Therefore, the current study evaluates the performance of varieties on yield and yield components of common bean during the main cropping season of 2015 and 2016 at four locations in Segen Zone,Konso woreda (Southwestern Ethiopia) with the objectives of  selecting high yielding common bean varieties those are adapted to the study area. Fifteen released common bean varieties and one local cultivar were planted in randomized complete block design with three replications. The analysis revealed that significant variation for all traits except maturity date. Highest yield obtained from Nasir(2136 kgha-1) and Hawassa dume (1948 kgha-1) followed by Sari (1751 kgha-1) were as at Addis Gebere, high grain yield was obtained from Sari (2227 kgha-1), Hawassa dume (2111 kgha-1) and Dimtu (2073 kgha-1). For average mean yield from overall location, high yield obtained from Hawassa dume (2129 kgha-1) and Nasir (2002 kgha-1) followed by Sari (1989 kgha-1). Results revealed that Hawassa dume, Nasir and Sari were best performed and better adapted varieties than the others respectively. Therefore, the above mentioned varieties are promising varieties for the production area and recommendable for area with similar agro-ecologies. Keywords: Phaseolus Vulagris L, Evaluation, Grain yield,Varieties

Effects of UV rays and natural compound repairs using an ex-vivo human skin model: morphological and genotoxicological analysis

Among the key factors in skin disorders such as wrinkling, dryness and photo-aging, the exposure to solar ultraviolet (UV) radiation plays a central role (1). Recently, compounds rich in polyphenols such as Thymus Vulgaris Leaf (TVL) extract and its major component Thymol (T) have been proposed in the prevention of UV-induced skin damages (2). Experiments were carried out in a human ex-vivo skin model, in which biopsies were obtained from aesthetic surgery of healthy 20-40 year-old women (n=6) after written informed consent (3). After 24 h, samples were pre-treated for 1 h with comparable concentrations of two compounds (TVL: 1.82 \ub5g/mL and T: 1 \ub5g/mL) before being irradiated with different UVB doses (0.24 J/cm2 to 0.72 J/cm2) or UVA radiation (8 J/cm2 to 32 J/cm2). Samples were harvested 24 h after irradiation and were processed both for light and transmission electron microscopy.Cell proliferation, Lactate Dehydrogenase assay, alkaline comet test, and histone H2AX phosphorylationwere evaluated. Both UVB and UVA induced an early inhibition of cell proliferation and DNA damage compared with respective controls. In particular, UVB rays were always more cytotoxic and genotoxic than UVA. The T-pretreatment showed a reduction of UVB-induced structural/ultrastructural and genotoxic damages. These results suggest that polyphenol fraction of tested substances may be useful for skin photoprotection after UV radiation damage in an ex-vivo human skin model. The present study suggests that this experimental setting can be a reliable approach for safety evaluation of UV skin exposure

Loggerhead Sea Turtle as Possible Source of Transmission for Zoonotic Listeriosis in the Marine Environment

Listeria monocytogenes is an ubiquitous pathogen isolated from different host species including fish, crustaceans, and molluscs, but it is rarely a pathogenic microorganism to marine reptiles. In particular, only two cases of fatal disseminated listeriosis have been described in the loggerhead sea turtle (Caretta caretta). In this study, we describe a lethal case of L. monocytogenes infection in a loggerhead sea turtle. The turtle was found alive, stranded on a beach in North-eastern Italy, but perished soon after being rescued. The autoptic examination revealed that heart, lung, liver, spleen, and urinary bladder were disseminated with multiple, firm, 0.1-0.5 mm sized, nodular, white-green lesions. Microscopically, these lesions corresponded with heterophilic granulomas with Gram+ bacteria within the necrotic center. Furthermore, the Ziehl-Neelsen stain was negative for acid-fast organisms. Colonies isolated from heart and liver were tested through MALDI-TOF for species identification, revealing the presence of L. monocytogenes. Whole Genome Sequencing on L. monocytogenes isolates was performed and the subsequent in silico genotyping revealed the belonging to Sequence Type 6 (ST 6); the virulence profile was evaluated, showing the presence of pathogenicity islands commonly observed in ST 6. Our results further confirm that L. monocytogenes should be posed in differential diagnosis in case of nodular lesions of loggerhead sea turtles; thus, given the zoonotic potential of the microorganism, animals should be treated with particular caution. In addition, wildlife animals can play an active role as carriers of possibly pathogenetic and virulent strains and contribute to the distribution of L. monocytogenes in the environment

Reduction in urea distribution volume over time in clinically stable dialysis patients

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Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the toxic as well as the addictive effects of opioids. 2) It is important that an opioid vaccine not interfere with the action of opioid antagonists used to reverse opioid overdose or treat addiction. 3) Some opioids are immunosuppressive and chronic ongoing opioid use could interfere with vaccine immunogenicity. 4) Although antibody-bound oxycodone is unable to enter the brain because of its size, it might still be able to activate peripheral opioid receptors. To assess vaccine impact on opioid toxicity, rats vaccinated with oxycodone conjugated to keyhole limpet hemocyanin subunit dimer (OXY-dKLH) adsorbed to alum or controls vaccinated with dKLH were compared with regard to oxycodone-induced hotplate analgesia and oxycodone-induced respiratory depression and bradycardia. Vaccination shifted the dose-response curves to the right, representing protection, for each of these endpoints. Naloxone was equally effective in both OXY-dKLH and control groups, providing complete and rapid reversal of respiratory depression. The administration of a long-acting naltrexone formulation during vaccination did not impair vaccine immunogenicity in mice. Similarly, serum anti-oxycodone antibody titers were not altered by continuous morphine infusion during vaccination compared to opioid-naïve controls. Competitive ELISA assay showed negligible or low affinity of immune antiserum for endogenous opioids or opioid antagonists. In vitro receptor binding assays showed that antibody-bound oxycodone does not activate mu opioid receptors. These data support further study of OXY-dKLH as a potential treatment for oxycodone abuse and suggest that vaccination might also reduce the severity of oxycodone overdose

Inclusive J/ψ production at mid-rapidity in pp collisions at √s = 5.02 TeV

Inclusive J/ψ production is studied in minimum-bias proton-proton collisions at a centre-of-mass energy of s = 5.02 TeV by ALICE at the CERN LHC. The measurement is performed at mid-rapidity (|y| < 0.9) in the dielectron decay channel down to zero transverse momentum pT, using a data sample corresponding to an integrated luminosity of Lint = 19.4 ± 0.4 nb−1. The measured pT-integrated inclusive J/ψ production cross sec- tion is dσ/dy = 5.64 ± 0.22(stat.) ± 0.33(syst.) ± 0.12(lumi.) μb. The pT-differential cross section d2σ/dpTdy is measured in the pT range 0–10 GeV/c and compared with state-of- the-art QCD calculations. The J/ψ 〈pT〉 and 〈pT2〉 are extracted and compared with results obtained at other collision energies. [Figure not available: see fulltext.]

Measurement of Λ (1520) production in pp collisions at √s=7TeV and p–Pb collisions at √sNN=5.02TeV

The production of the Λ (1520) baryonic resonance has been measured at midrapidity in inelastic pp collisions at s=7TeV and in p–Pb collisions at sNN=5.02TeV for non-single diffractive events and in multiplicity classes. The resonance is reconstructed through its hadronic decay channel Λ (1520) → pK - and the charge conjugate with the ALICE detector. The integrated yields and mean transverse momenta are calculated from the measured transverse momentum distributions in pp and p–Pb collisions. The mean transverse momenta follow mass ordering as previously observed for other hyperons in the same collision systems. A Blast-Wave function constrained by other light hadrons (π, K, KS0, p, Λ) describes the shape of the Λ (1520) transverse momentum distribution up to 3.5GeV/c in p–Pb collisions. In the framework of this model, this observation suggests that the Λ (1520) resonance participates in the same collective radial flow as other light hadrons. The ratio of the yield of Λ (1520) to the yield of the ground state particle Λ remains constant as a function of charged-particle multiplicity, suggesting that there is no net effect of the hadronic phase in p–Pb collisions on the Λ (1520) yield