High strength steel in fire

High-performance materials are necessary to meet the future demands of the construction industry, which is strongly influenced by a growing population and depletion of natural resources. Sustainable development is central to research and development into innovative structural materials, and requires solutions to be economically viable whilst equally providing a positive contribution towards environmental and social factors. High strength steels (HSS) have the potential to contribute towards such demands by reducing the weight of structures when employed in appropriate applications. Lighter structures require smaller foundations, shorter transportation and construction times and also lower CO2 emissions. A particular challenge related to the use of HSS in structures include increased likelihood of stability issues resulting from the reduction in section thickness, and limiting deflection and vibration criteria are also more likely to be critical. Nevertheless, when used appropriately, they can provide a sustainable solution. Their use in structural applications is further hindered by a lack of performance data and design guidance under fire conditions. This paper compares the mechanical properties, particularly strength and stiffness of HSS (yield strengths between 460-700 MPa) and mild steel (yields between 235-460 MPa) at elevated temperatures, through a critical review of published literature. Various alloying and processing routes used to achieve high yield strength are assessed. At the same time, the review considers available information on the strengthening mechanisms that can be utilised to retain the strength and/or stiffness of the material in the event of a fire. Using the information gathered, an extensive testing programme is developed which will enable design guidance for the fire design of HSS structures to be proposed.Engineering and Physical Sciences Research Council, TW

Influenza vaccine as a coronary intervention for prevention of myocardial infarction.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. Influenza is one of the leading infectious causes of morbidity and mortality globally, and evidence is accumulating that it can precipitate acute myocardial infarction (AMI). This is thought to be due to a range of factors including inflammatory release of cytokines, disruption of atherosclerotic plaques and thrombogenesis, which may acutely occlude a coronary artery. There is a large body of observational and clinical trial evidence that shows that influenza vaccine protects against AMI. Estimates of the efficacy of influenza vaccine in preventing AMI range from 15% to 45%. This is a similar range of efficacy compared with the accepted routine coronary prevention measures such as smoking cessation (32-43%), statins (19-30%) and antihypertensive therapy (17-25%). Influenza vaccine should be considered as an integral part of CVD management and prevention. While it is recommended in many guidelines for patients with CVD, rates of vaccination in risk groups aged <65 years are very low, in the range of 30%. The incorporation of vaccination into routine CVD prevention in patient care requires a clinical practice paradigm change

HOPE: Help fOr People with money, employment, benefit or housing problems: study protocol for a randomised controlled trial

Background: Self-harm and suicide increase in times of economic recession. Factors including job loss, austerity measures, financial difficulties and house repossession contribute to the risk. Vulnerable individuals commonly experience difficulties in navigating the benefits system and in accessing the available sources of welfare and debt advice, and this contributes to their distress. Our aim is to determine the feasibility and acceptability of a brief psychosocial intervention (the “HOPE” service) for people presenting to hospital emergency departments (ED) following self-harm or in acute distress because of financial, employment, or welfare (benefit) difficulties. Method: A pilot study including randomisation will be employed to determine whether it is possible to undertake a full-scale trial. Twenty people presenting to the ED who have self-harmed, have suicidal thoughts and depression and/or are in crisis and where financial, employment or benefit problems are cited as contributory factors will be asked to consent to random allocation to the intervention or control arm on a 2:1 basis. People who require secondary mental health follow-up will be excluded. Those randomised to the intervention arm will receive up to six sessions with a mental health worker who will provide practical help with financial and other problems. The mental health worker will use the motivational interviewing method in their interactions with participants. Control participants will receive one session signposting them to existing relevant support organisations. Participants will be followed up after 3 months. Participants and the mental health workers will take part in qualitative interviews to enable refinement of the intervention. The acceptability of outcome measures including the PHQ-9, GAD-7, repeat self-harm, EQ5D-5L and questions about debt, employment and welfare benefits will be explored. Discussion: This study will assess whether a full-scale randomised trial of this novel intervention to prevent self-harm among those distressed because of financial difficulties is feasible, including the acceptability of randomisation, potential rate of recruitment and the acceptability of outcome measures. Trial registration: ISRCTN5853124

Watching movies unfold - a frame-by-frame analysis of the associated neural dynamics

Our lives unfold as sequences of events. We experience these events as seamless, although they are composed of individual images captured in between the interruptions imposed by eye blinks and saccades. Events typically involve visual imagery from the real world (scenes), and the hippocampus is frequently engaged in this context. It is unclear, however, whether the hippocampus would be similarly responsive to unfolding events that involve abstract imagery. Addressing this issue could provide insights into the nature of its contribution to event processing, with relevance for theories of hippocampal function. Consequently, during magnetoencephalography (MEG), we had female and male humans watch highly matched unfolding movie events composed of either scene image frames that reflected the real world, or frames depicting abstract patterns. We examined the evoked neuronal responses to each image frame along the time course of the movie events. Only one difference between the two conditions was evident, and that was during the viewing of the first image frame of events, detectable across frontotemporal sensors. Further probing of this difference using source reconstruction revealed greater engagement of a set of brain regions across parietal, frontal, premotor, and cerebellar cortices, with the largest change in broadband (1–30 Hz) power in the hippocampus during scene-based movie events. Hippocampal engagement during the first image frame of scene-based events could reflect its role in registering a recognizable context perhaps based on templates or schemas. The hippocampus, therefore, may help to set the scene for events very early on

Revisiting the De-Radicalisation or Disengagement Debate: Public Attitudes to the Re-Integration of Terrorists

The article reports on the findings of an experimental survey which was conducted to ascertain the level of support and perceived effectiveness of using de-radicalisation programmes to re-integrate returning foreign fighters. Public support (or the lack of opposition) for re-integration programmes can be important in ensuring the programmes have the time, resources and opportunity to be successful however we know little about what wider society thinks about re-integration programmes. The article explores the extent to which the inclusion of de-radicalisation – in name and content – changes attitudes to a re-integration programme. This is relevant in showing attitudes to de-radicalisation over disengagement and whether de-radicalisation, while perhaps not more effective at the programme-level, is or is not more effective at generating public support for re-integration (and thereby facilitating the process itself). We find that the inclusion of de-radicalisation in the name and content of a re-integration programme to a small extent increases support for re-integration over a programme that uses the terms disengagement and desistance. However, we also find that while de-radicalisation increases support, it also decreases perceived effectiveness, leading respondents to feel it makes the country less safe and less likely to reduce the re-offending rate than if the programme excludes de-radicalisation. We argue this polarising effect is reflective of wider reasons for supporting the policies (e.g. de-radicalisation may be seen as a form of ideational/normative punishment) and that the term de-radicalisation may shift the framing of the problematic to entrenched social structures, thus rendering itself ineffective as a policy treatment. In terms of policy, we argue there is a necessity for greater openness about re-integration programmes and that governments would benefit from selling the programmes to the public. We conclude our paper with a justification of focusing further research on understanding public/community attitudes to re-integration programmes and understanding the PR of counter-terrorism policies more generally

Multilevel ultrafast flexible nanoscale nonvolatile hybrid graphene oxide-titanium oxide memories

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Graphene oxide (GO) resistive memories offer the promise of low-cost environmentally sustainable fabrication, high mechanical flexibility and high optical transparency, making them ideally suited to future flexible and transparent electronics applications. However, the dimensional and temporal scalability of GO memories, i.e., how small they can be made and how fast they can be switched, is an area that has received scant attention. Moreover, a plethora of GO resistive switching characteristics and mechanisms has been reported in the literature, sometimes leading to a confusing and conflicting picture. Consequently, the potential for graphene oxide to deliver high-performance memories operating on nanometer length and nanosecond time scales is currently unknown. Here we address such shortcomings, presenting not only the smallest (50 nm), fastest (sub-5 ns), thinnest (8 nm) GO-based memory devices produced to date, but also demonstrate that our approach provides easily accessible multilevel (4-level, 2-bit per cell) storage capabilities along with excellent endurance and retention performance-all on both rigid and flexible substrates. Via comprehensive experimental characterizations backed-up by detailed atomistic simulations, we also show that the resistive switching mechanism in our Pt/GO/Ti/Pt devices is driven by redox reactions in the interfacial region between the top (Ti) electrode and the GO layer.This work was carried out under the auspices of the EU FP7 project CareRAMM. This project received funding from the European Union Seventh Framework Programme (FP7/2007- 2013) under grant agreement no. 309980. The authors are grateful for helpful discussions with all CareRAMM partners, particularly Prof. Andrea Ferrari and Ms. Anna Ott at the University of Cambridge, and Drs. Abu Sebastian and Wabe Koelmans at IBM Research Zurich. We also gratefully acknowledge the assistance of the National EPSRC XPS User’s Service (NEXUS) at Newcastle University, U.K. (an EPSRC Mid-Range Facility) in carrying out the XPS measurement

Pulmonary vasoconstrictor action of KCNQ potassium channel blockers

KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence spontaneous contractile activity. The biophysical properties of K+ currents mediated by KCNQ channels resemble a current underlying the resting K+ conductance and resting potential of pulmonary artery smooth muscle cells. We therefore investigated a possible role of KCNQ channels in regulating the function of pulmonary arteries by determining the ability of the selective KCNQ channel blockers, linopirdine and XE991, to promote pulmonary vasoconstriction. Linopirdine and XE991 both contracted rat and mouse pulmonary arteries but had little effect on mesenteric arteries. In each case the maximum contraction was almost as large as the response to 50 mM K+. Linopirdine had an EC50 of around 1 μM and XE991 was almost 10-fold more potent. Neither removal of the endothelium nor exposure to phentolamine or α,β-methylene ATP, to block α1-adrenoceptors or P2X receptors, respectively, affected the contraction. Contraction was abolished in Ca2+-free solution and in the presence of 1 μM nifedipine or 10 μM levcromakalim

Perception of Filtered Speech by Children with Developmental Dyslexia and Children with Specific Language Impairments

Here we use two filtered speech tasks to investigate children’s processing of slow (<4 Hz) versus faster (∼33 Hz) temporal modulations in speech. We compare groups of children with either developmental dyslexia (Experiment 1) or speech and language impairments (SLIs, Experiment 2) to groups of typically-developing (TD) children age-matched to each disorder group. Ten nursery rhymes were filtered so that their modulation frequencies were either low-pass filtered (<4 Hz) or band-pass filtered (22 – 40 Hz). Recognition of the filtered nursery rhymes was tested in a picture recognition multiple choice paradigm. Children with dyslexia aged 10 years showed equivalent recognition overall to TD controls for both the low-pass and band-pass filtered stimuli, but showed significantly impaired acoustic learning during the experiment from low-pass filtered targets. Children with oral SLIs aged 9 years showed significantly poorer recognition of band pass filtered targets compared to their TD controls, and showed comparable acoustic learning effects to TD children during the experiment. The SLI samples were also divided into children with and without phonological difficulties. The children with both SLI and phonological difficulties were impaired in recognizing both kinds of filtered speech. These data are suggestive of impaired temporal sampling of the speech signal at different modulation rates by children with different kinds of developmental language disorder. Both SLI and dyslexic samples showed impaired discrimination of amplitude rise times. Implications of these findings for a temporal sampling framework for understanding developmental language disorders are discusse

Field-dependent Behavior of AC Susceptibility in [Y<inf>0.8</inf>Ca<inf>0.2</inf>](Ba<inf>0.5</inf>Sr<inf>0.5</inf>)<inf>2</inf>Cu<inf>3</inf>O<inf>7−δ</inf>

The AC susceptibility of [Y0.8Ca0.2](Ba0.5Sr0.5)2 Cu3O7−δ was investigated as a function of frequency and amplitude of AC magnetic field. The susceptibilities of the sample display the field amplitude dependence. The peak temperature (Tp) of its imaginary part shows not frequency dependence but field amplitude dependence. The frequency effect on AC susceptibility was negligible. As the field amplitude increases, Tp shifts to lower temperature. This effect can be interpreted in terms of bulk pinning hysteresis loss due to the vortices motion in/out grain boundary.The work in Peru has been supported by the Superior Council of Research of the National University of San Marcos (Grant No. 151301031). This work was also supported by the National Research Foundation of President Post-doctoral fellowship Program (NRF-2013R1A6A3A060443). “L. De Los Santos thanks the Ministry of the Production “Programa Nacional de Innovacion´ para la Competitividad y Productividad” for financial support (Project ECIP-1-P-069-14)”.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s10948-015-3238-