THE PREVALENCE OF BURNOUT SYNDROME AMONG RESIDENTS OF DOKUZ EYLUL UNİVERSITY SCHOOL OF MEDICINE

Amaç: Tükenmişlik sendromu, sağlık çalışanları arasında sık görülen bir durumdur. Bununla birlikte ülkemizde, Tıpta Uzmanlık Öğrencilerinin (TUÖ) tükenmişlik düzeylerini karşılaştıran çalışmaların sayısı kısıtlıdır. Çalışmamızda Dokuz Eylül Üniversitesi Hastanesindeki temel, dahili ve cerrahi tıp bilimlerindeki tıpta uzmanlık öğrencilerinin tükenmişlik düzeyini ölçmeyi amaçladık. Yöntemler: Çalışmamızda Dokuz Eylül Üniversitesi Hastanesinde çalışan cerrahi, dahili ve temel bilimlerdeki TUÖ'lerine anket yöntemi ile Maslach Tükenmişlik Ölçeği uygulandı ve meslekleri ile ilgili düşünceleri soruldu. Farklı dallardaki TUÖ'lerinin tükenmişlik düzeyleri birbirleri ile karşılaştırıldı. Bulgular: Hastanemizde çalışan 189 TUÖ (16 temel bilim TUÖ, 126 dahili bilim TUÖ, 47 cerrahi bilim TUÖ) çalışmaya alındı. Katılımcıların %50,8' i kadın, yaş ortalaması 28,4 ± 3,1 idi. Maslach Tükenmişlik Ölçeğinde TUÖ'lerinin ortalama duygusal tükenmişlik (DT) puanı 19,17 ± 8,37, Duyasızlaşma (DYS) puanı 18,97 ± 7,73 ve Kişisel Başarı (KB) puanı 24,35 ± 6,27 olarak hesaplandı. DT ve DYS puanlarında temel bilim TUÖ'leri diğer bölümlere göre daha düşük puan alırken (her biri için p<0,001), cerrahi ve dahili bilim TUÖ'lerinin arasında fark yoktu. Dahili bilim TUÖ'leri, cerrahi bilim TUÖ'lerine göre daha yüksek KB puanına sahipti (p=0,037). Temel bilim TUÖ'leri ile cerrahi ve dahili bilim TUÖ'leri arasında KB puanı açısından fark yoktu. Sonuç: Dahili ve cerrahi bilim TUÖ'lerinin DT ve DYS puanları, temel bilim TUÖ'lerinden daha yüksektir. Dahili bilim TUÖ'leri en yüksek, temel bilim TUÖ'leri en düşük KB puanına sahiptir Objective: Burnout syndrome is common among healthcare workers. However the studies of resident physicians burnout levels measurements are limited in our country. In our study we aimed of measure the levels of burnout in different branch residents in Dokuz Eylul University hospital. Methods: In our study Maslach Burnout Scale were performed to different branch residents in Dokuz Eylul University hospital by the survey method and asked about thoughts related to their profession. Burnout levels of the residents in different branches were compared with each other. Results: 189 residents from the basic medical sciences and surgical and internal medicine departments of Dokuz Eylul University hospital were included in the study. 16 of the residents participating in the study were from basic medical sciences and 126 from internal medical departments and 47 from surgical departments. 50,8% of the residents were women and the mean age was 28.4 ± 3.1. Average Emotional Exhaustion (EE) score was 19.17 ± 8.37, Depersonalization (DP) score was 18.97 ± 7.73 and Personal Accomplishment (PA) was 24.35 ± 6.27. EE and DP scores were lowest in basic sciences residents than other branches (each of them p<0.001) altough there were no significiant difference in EE and DP scores between surgical and internal medical residents. Internal medical residents PA score higher than the surgery residents (p=0.037). There were no significiant difference in PA scores between basic sciences residents and surgical departments residents and inernal medical departments residents.  Conclusion: EE and DP scores of internal medicine and surgical departments residents are higher than basic sciences residents. Internal medicine residents have the highest and basic sciences residents have the lowest PA scor

Calpain-3 mutations in Turkey

Abstract Autosomal recessive limb-girdle muscular dystrophies (LGMD2s

An application of creating and packaging learning objects

World Conference on Educational Sciences -- FEB 04-07, 2009 -- Nicosia, CYPRUSWOS: 000275580400350Finding learning content is one of the problems that most learners face while developing their knowledge on the Internet. Should learning objects have special descriptive data along themselves; they could easily be found by learners. In such a case, it is necessary to package learning content in to a learning object. In this paper, materializing learning objects using Adobe Captivate and application of these learning objects in an experimental setting is discussed. (C) 2009 Elsevier Ltd. All rights reserve

Comparison of The International Federation of Gynecology and Obstetrics (FIGO) 2018 and 2009 Staging Systems for Operated Cervical Carcinoma

OBJECTIVE The purpose of the study was to compare FIGO 2009 and 2018 uterine cervical carcinoma staging systems in terms of patient distribution and efficacy in predicting treatment outcome in patients treated with surgery and adjuvant radiotherapy (RT)+/-concomitant chemotherapy (CT). METHODS The records of 184 uterine cervical cancer patients treated with post-operative RT/RCT from 2007 to 2017 were retrospectively reviewed. Surgical procedure was in the form of Wertheim surgery in 96 patients (52%) and pelvic lymph node dissection was performed in 32 patients (17.5%). One hundred and sixty-six patients (87.5%) received both external RT and intracavitary brachytherapy, and 23 (12.5%) patients were treated only with external RT. RESULTS The median follow-up time was 61.5 months (range, 8-132 moths). One hundred and fifty-one (82%) patients were alive, and 144 (94%) of these were free of disease at the time of this analysis. The median time for locoregional failure and distant metastasis were 25 months (range, 8-88 months) and 38 months (range, 12-118 months). Stage migration was recorded in 130 patients (70.7%) in our series when the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system was used. The most remarkable stage migration was detected for Stage I patients. A total of 119 (64.6%) patients with Stage I showed stage migration. Five-year locoregional control, disease-free survival, disease-specific survival, and overall survival rates were 91%, 88%, 91%, and 83%, respectively. CONCLUSION The updated FIGO staging system for invasive cervical cancer incorporates imaging and pathological findings. Our results suggest us that the major improvement of 2018 staging system for uterine cervical carcinoma is that it produced better discrimination in terms of survival outcome in patients with lymph node metastases both pelvic and para-aortic

The Effects of Home Exercise Program on Balance and Functional Capacity in Parkinsonian Patients

Objective: The aim of our study is to investigate the effects of home exercise program on balance, postural control, coordination and functional strengthening in parkinsonian patients

Role of vaginal brachytherapy boost following adjuvant external beam radiotherapy in cervical cancer: Turkish Society for Radiation Oncology Gynecologic Group Study (TROD 04-002)

Objectiv

Mutation in Exon 1f of PLEC, Leading to Disruption of Plectin Isoform 1f, Causes Autosomal-Recessive Limb-Girdle Muscular Dystrophy

Limb-girdle muscular dystrophy (LGMD) is a genetically heterogeneous group of inherited muscular disorders manifesting symmetric, proximal, and slowly progressive muscle weakness. Using Affymetrix 250K SNP Array genotyping and homozygosity mapping, we mapped an autosomal-recessive LGMD phenotype to the telomeric portion of chromosome 8q in a consanguineous Turkish family with three affected individuals. DNA sequence analysis of PLEC identified a homozygous c.1_9del mutation containing an initiation codon in exon 1f, which is an isoform-specific sequence of plectin isoform 1f. The same homozygous mutation was also detected in two additional families during the analysis of 72 independent LGMD2-affected families. Moreover, we showed that the expression of PLEC was reduced in the patient's muscle and that there was almost no expression for plectin 1f mRNA as a result of the mutation. In addition to dystrophic changes in muscle, ultrastructural alterations, such as membrane duplications, an enlarged space between the membrane and sarcomere, and misalignment of Z-disks, were observed by transmission electron microscopy. Unlike the control skeletal muscle, no sarcolemmal staining of plectin was detected in the patient's muscle. We conclude that as a result of plectin 1f deficiency, the linkage between the sarcolemma and sarcomere is broken, which could affect the structural organization of the myofiber. Our data show that one of the isoforms of plectin plays a key role in skeletal muscle function and that disruption of the plectin 1f can cause the LGMD2 phenotype without any dermatologic component as was previously reported with mutations in constant exons of PLEC

Large Expression in Different Types of Muscular Dystrophies other than Dystroglycanopathy

Background Alpha-dystroglycan (αDG) is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin globular domains and certain arenaviruses. An important enzyme, known as Like-acetylglucosaminyltransferase (LARGE), has been shown to transfer repeating units of -glucuronic acid-β1,3-xylose-α1,3- (matriglycan) to αDG that is required for functional receptor as an extracellular matrix protein scaffold. The reduction in the amount of LARGE-dependent matriglycan result in heterogeneous forms of dystroglycanopathy that is associated with hypoglycosylation of αDG and a consequent lack of ligand-binding activity. Our aim was to investigate whether LARGE expression showed correlation with glycosylation of αDG and histopathological parameters in different types of muscular dystrophies, except for dystroglycanopathies. Methods The expression level of LARGE and glycosylation status of αDG were examined in skeletal muscle biopsies from 26 patients with various forms of muscular dystrophy [Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), sarcoglycanopathy, dysferlinopathy, calpainopathy, and merosin and collagen VI deficient congenital muscular dystrophies (CMDs)] and correlation of results with different histopathological features was investigated. Results Despite the fact that these diseases are not caused by defects of glycosyltransferases, decreased expression of LARGE was detected in many patient samples, partly correlating with the type of muscular dystrophy. Although immunolabelling of fully glycosylated αDG with VIA4–1 was reduced in dystrophinopathy patients, no significant relationship between reduction of LARGE expression and αDG hypoglycosylation was detected. Also, Merosin deficient CMD patients showed normal immunostaining with αDG despite severe reduction of LARGE expression. Conclusions Our data shows that it is not always possible to correlate LARGE expression and αDG glycosylation in different types of muscular dystrophies and suggests that there might be differences in αDG processing by LARGE which could be regulated under different pathological conditions.PubMedWoSScopu