Ambient connections realising conformal Tractor holonomy

For a conformal manifold we introduce the notion of an ambient connection, an affine connection on an ambient manifold of the conformal manifold, possibly with torsion, and with conditions relating it to the conformal structure. The purpose of this construction is to realise the normal conformal tractor holonomy as affine holonomy of such a connection. We give an example of an ambient connection for which this is the case, and which is torsion free if we start the construction with a C-space, and in addition Ricci-flat if we start with an Einstein manifold. Thus for a $C$-space this example leads to an ambient metric in the weaker sense of \v{C}ap and Gover, and for an Einstein space to a Ricci-flat ambient metric in the sense of Fefferman and Graham.Comment: 17 page

Method for Reducing Nitrosamines in Tobacco

Nitrosamines are reduces in tobacco by treating a whole tobacco lead with ferulic acid. Treatment is conducted by applying an aqueous solution of ferulic acid to the whole tobacco lead immediately before, at, or after harvesting, or fire curing the whole tobacco lead with wood smoke containing the ferulic acid

The GaAs solar cells with V-grooved emitters

Geometrically structured surfaces have become increasingly important to solar cell efficiency improvements and radiation tolerance. Gallium arsenide solar cells with a V-grooved front surface which demonstrate improved optical coupling and higher short-circuit current compared to planar cells were fabricated. GaAs homojunction cells were fabricated by organometallic chemical vapor deposition (OMCVD) on an n+ substrate. The V-grooves were formed on the surface with an anisotropic etch, and an n-type buffer and p-type emitter were grown by OMCVD, followed by ohmic contacts. Reflectivity measurements show significantly lower reflectance for the microgrooved cell compared to the planar structure. The short circuit current of the V-grooved solar cell is consistently higher than that of the planar controls

Laboratory Measurements Of White Dwarf Photospheric Spectral Lines: H Beta

We spectroscopically measure multiple hydrogen Balmer line profiles from laboratory plasmas to investigate the theoretical line profiles used in white dwarf (WD) atmosphere models. X-ray radiation produced at the Z Pulsed Power Facility at Sandia National Laboratories initiates plasma formation in a hydrogen-filled gas cell, replicating WD photospheric conditions. Here we present time-resolved measurements of H beta and fit this line using different theoretical line profiles to diagnose electron density, n(e), and n = 2 level population, n2. Aided by synthetic tests, we characterize the validity of our diagnostic method for this experimental platform. During a single experiment, we infer a continuous range of electron densities increasing from n(e) similar to 4 to similar to 30 x 10(16) cm(-3) throughout a 120-ns evolution of our plasma. Also, we observe n(2) to be initially elevated with respect to local thermodynamic equilibrium (LTE); it then equilibrates within similar to 55 ns to become consistent with LTE. This supports our electrontemperature determination of T-e similar to 1.3 eV (similar to 15,000 K) after this time. At n(e) greater than or similar to 10(17) cm(-3), we find that computer-simulation-based line-profile calculations provide better fits (lower reduced chi(2)) than the line profiles currently used in the WD astronomy community. The inferred conditions, however, are in good quantitative agreement. This work establishes an experimental foundation for the future investigation of relative shapes and strengths between different hydrogen Balmer lines.Laboratory Directed Research and Development programUnited States Department of Energy DE-AC04-94AL85000, DE-SC0010623National Science Foundation DGE-1110007Astronom

A V-grooved GaAs solar cell

V-grooved GaAs solar cells promise the benefits of improved optical coupling, higher short-circuit current, and increased tolerance to particle radiation compared to planar cells. A GaAs homojunction cell was fabricated by etching a V-groove pattern into an n epilayer (2.1 x 10 to the 17th power per cu cm) grown by metalorganic chemical vapor deposition (MOCVD) on an n+ substrate (2.8 x 10 to the 18th power per cu cm) and then depositing and MOCVD p epilayer (4.2 x 10 to the 18th power per cu cm). Reflectivity measurements on cells with and without an antireflective coating confirm the expected decrease in reluctance of the microgrooved cell compared to the planar structure. The short circuit current of the V-grooved solar cell was 13 percent higher than that of the planar control

How to Find More Supernovae with Less Work: Object Classification Techniques for Difference Imaging

We present the results of applying new object classification techniques to difference images in the context of the Nearby Supernova Factory supernova search. Most current supernova searches subtract reference images from new images, identify objects in these difference images, and apply simple threshold cuts on parameters such as statistical significance, shape, and motion to reject objects such as cosmic rays, asteroids, and subtraction artifacts. Although most static objects subtract cleanly, even a very low false positive detection rate can lead to hundreds of non-supernova candidates which must be vetted by human inspection before triggering additional followup. In comparison to simple threshold cuts, more sophisticated methods such as Boosted Decision Trees, Random Forests, and Support Vector Machines provide dramatically better object discrimination. At the Nearby Supernova Factory, we reduced the number of non-supernova candidates by a factor of 10 while increasing our supernova identification efficiency. Methods such as these will be crucial for maintaining a reasonable false positive rate in the automated transient alert pipelines of upcoming projects such as PanSTARRS and LSST.Comment: 25 pages; 6 figures; submitted to Ap

Time-Dependence of the Mass Accretion Rate in Cluster Cooling Flows

We analyze two time-dependent cluster cooling flow models in spherical symmetry. The first assumes that the intracluster gas resides in a static external potential, and includes the effects of optically thin radiative cooling and mass deposition. This corresponds to previous steady-state cooling flow models calculated by White & Sarazin (1987). Detailed agreement is found between steady-state models and time-dependent models at fixed times in the simulations. The mass accretion rate is found either to increase or remain nearly constant once flows reach a steady state. The time rate of change of the accretion rate is strongly sensitive to the value of the mass deposition parameter q, but only mildly sensitive to the ratio beta of gravitational binding energy to gas temperature. We show that previous scaling arguments presented by Bertschinger (1988) and White (1988) are valid only for mature cooling flows with weak mass deposition (q ~< 1). The second set of models includes the effects of a secularly deepening cluster potential and secondary infall of gas from the Hubble flow. We find that such heating effects do not prevent the flows from reaching a steady state within an initial central cooling time.Comment: 22 pages (AASTeX) with 16 EPS figures; accepted for publication in The Astrophysical Journa

PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells

G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability. Here we report that PrimPol, a recently described primase-polymerase (PrimPol), plays a crucial role in the bypass of leading strand G4 structures. While PrimPol is unable to directly replicate G4s, it can bind and reprime downstream of these structures. Disruption of either the catalytic activity or zinc-finger of PrimPol results in extreme G4-dependent epigenetic instability at the BU-1 locus in avian DT40 cells, indicative of extensive uncoupling of the replicative helicase and polymerase. Together, these observations implicate PrimPol in promoting restart of DNA synthesis downstream of, but closely coupled to, G4 replication impediments

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease. Loss of function of the nuclear receptor REV-ERB is associated with reduced cognitive function in mouse models. The effect of enhanced REV-ERB activity on cognitive function has not been examined. In this study, we tested the hypothesis that enhanced REV-ERB function may enhance cognitive function in a model of Alzheimer’s disease. We utilized the REV-ERB agonist SR9009 to pharmacologically activate the activity of REV-ERB in the SAMP8 mouse model of Alzheimer’s disease. SR9009 reversed cognitive dysfunction of an aged SAMP8 mouse in several behavioral assays including novel object recognition, T-maze foot shock avoidance, and lever press operant conditioning task assessments. SR9009 treatment reduced amyloid-β 1–40 and 1–42 levels in the cortex, which is consistent with improved cognitive function. Furthermore, SR9009 treatment led to increased hippocampal PSD-95, cortical synaptophysin expression and the number of synapses suggesting improvement in synaptic function. We conclude that REV-ERB is a potential target for treatment of Alzheimer’s disease.</div