236 research outputs found
Four Zero Texture Fermion Mass Matrices in SO(10) GUT
We attempt the integration of the phenomenologically successful four zero
texture of fermion mass matrices with the renormalizable SO(10) GUT. The
resulting scenario is found to be highly predictive. Firstly, we examine the
phenomenological implications of a class of the lepton mass matrices with
parallel texture structures and obtain interesting constraints on the
parameters of the charged lepton and the neutrino mass matrices. We combine
these phenomenological constraints with the constraints obtained from SO(10)
GUT to reduce the number of the free parameters and to further constrain the
allowed ranges of the free parameters. The solar/atmospheric mixing angles
obtained in this analysis are in fairly good agreement with the data.Comment: 14 pages, 3 figures, 1 tabl
Mask formulas for cograssmannian Kazhdan-Lusztig polynomials
We give two contructions of sets of masks on cograssmannian permutations that
can be used in Deodhar's formula for Kazhdan-Lusztig basis elements of the
Iwahori-Hecke algebra. The constructions are respectively based on a formula of
Lascoux-Schutzenberger and its geometric interpretation by Zelevinsky. The
first construction relies on a basis of the Hecke algebra constructed from
principal lower order ideals in Bruhat order and a translation of this basis
into sets of masks. The second construction relies on an interpretation of
masks as cells of the Bott-Samelson resolution. These constructions give
distinct answers to a question of Deodhar.Comment: 43 page
Protocol for process evaluation of a randomised controlled trial of family-led rehabilitation post stroke (ATTEND) in India
Introduction We are undertaking a randomised controlled trial (fAmily led rehabiliTaTion aftEr stroke in INDia, ATTEND) evaluating training a family carer to enable maximal rehabilitation of patients with stroke-related disability; as a potentially affordable, culturally acceptable and effective intervention for use in India. A process evaluation is needed to understand how and why this complex intervention may be effective, and to capture important barriers and facilitators to its implementation. We describe the protocol for our process evaluation to encourage the development of in-process evaluation methodology and transparency in reporting.
Methods and analysis The realist and RE-AIM (Reach, Effectiveness, Adoption, Implementation and Maintenance) frameworks informed the design. Mixed methods include semistructured interviews with health providers, patients and their carers, analysis of quantitative process data describing fidelity and dose of intervention, observations of trial set up and implementation, and the analysis of the cost data from the patients and their families perspective and programme budgets. These qualitative and quantitative data will be analysed iteratively prior to knowing the quantitative outcomes of the trial, and then triangulated with the results from the primary outcome evaluation.
Ethics and dissemination The process evaluation has received ethical approval for all sites in India. In low-income and middle-income countries, the available human capital can form an approach to reducing the evidence practice gap, compared with the high cost alternatives available in established market economies. This process evaluation will provide insights into how such a programme can be implemented in practice and brought to scale. Through local stakeholder engagement and dissemination of findings globally we hope to build on patient-centred, cost-effective and sustainable models of stroke rehabilitation.
Trial registration number CTRI/2013/04/003557
Calculation of the Flux of Atmospheric Neutrinos
Atmospheric neutrino-fluxes are calculated over the wide energy range from 30
MeV to 3,000 GeV for the study of neutrino-physics using the data from
underground neutrino-detectors. The atmospheric muon-flux at high altitude and
at sea level is studied to calibrate the neutrino-fluxes at low energies and
high energies respectively. The agreement of our calculation with observations
is satisfactory. The uncertainty of atmospheric neutrino-fluxes is also
studied.Comment: 51 page
The Formation and Evolution of Massive Stellar Clusters in IC 4662
We present a multiwavelength study of the formation of massive stellar
clusters, their emergence from cocoons of gas and dust, and their feedback on
surrounding matter. Using data that span from radio to optical wavelengths,
including Spitzer and Hubble ACS observations, we examine the population of
young star clusters in the central starburst region of the irregular Wolf-Rayet
galaxy IC 4662. We model the radio-to-IR spectral energy distributions of
embedded clusters to determine the properties of their HII regions and dust
cocoons (sizes, masses, densities, temperatures), and use near-IR and optical
data with mid-IR spectroscopy to constrain the properties of the embedded
clusters themselves (mass, age, extinction, excitation, abundance). The two
massive star-formation regions in IC 4662 are excited by stellar populations
with ages of ~ 4 million years and masses of ~ 3 x 10^5 M_sun (assuming a
Kroupa IMF). They have high excitation and sub-solar abundances, and they may
actually be comprised of several massive clusters rather than the single
monolithic massive compact objects known as Super Star Clusters (SSCs). Mid-IR
spectra reveal that these clusters have very high extinctions, A_V ~ 20-25 mag,
and that the dust in IC 4662 is well-mixed with the emitting gas, not in a
foreground screen.Comment: 7 pages, 11 figures, to appear in proceedings of the conference
"Young Massive Star Clusters: Initial Conditions and Environments ", held in
Granada, Spain, September 200
Desenvolvimento e avaliação de um teste ELISA indireto para o diagnóstico sorológico do mormo em equídeos
Critical electrolyte concentration of spermatozoal chromatin containing histone H1 variants
Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)
BACKGROUND:
Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control.
METHODS:
Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights.
FINDINGS:
5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease.
INTERPRETATION:
International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society
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