279 research outputs found
Strong coupling between single-electron tunneling and nano-mechanical motion
Nanoscale resonators that oscillate at high frequencies are useful in many
measurement applications. We studied a high-quality mechanical resonator made
from a suspended carbon nanotube driven into motion by applying a periodic
radio frequency potential using a nearby antenna. Single-electron charge
fluctuations created periodic modulations of the mechanical resonance
frequency. A quality factor exceeding 10^5 allows the detection of a shift in
resonance frequency caused by the addition of a single-electron charge on the
nanotube. Additional evidence for the strong coupling of mechanical motion and
electron tunneling is provided by an energy transfer to the electrons causing
mechanical damping and unusual nonlinear behavior. We also discovered that a
direct current through the nanotube spontaneously drives the mechanical
resonator, exerting a force that is coherent with the high-frequency resonant
mechanical motion.Comment: Main text 12 pages, 4 Figures, Supplement 13 pages, 6 Figure
The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation
Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3). After dietary intake, LC-PUFA are incorporated into membranes and can be converted to their corresponding N-acylethanolamines (NAE). However, little is known on the biological role of these metabolites. In the present study, we tested a series of unsaturated NAE on the lipopolysaccharide (LPS)-induced NO production in RAW264.7 macrophages. Among the compounds tested, docosahexaenoylethanolamine (DHEA), the ethanolamide of DHA, was found to be the most potent inhibitor, inducing a dose-dependent inhibition of NO release. Immune-modulating properties of DHEA were further studied in the same cell line, demonstrating that DHEA significantly suppressed the production of monocyte chemotactic protein-1 (MCP-1), a cytokine playing a pivotal role in chronic inflammation. In LPS-stimulated mouse peritoneal macrophages, DHEA also reduced MCP-1 and NO production. Furthermore, inhibition was also found to take place at a transcriptional level, as gene expression of MCP-1 and inducible NO synthase was inhibited by DHEA. To summarise, in the present study, we showed that DHEA, a DHA-derived NAE metabolite, modulates inflammation by reducing MCP-1 and NO production and expression. These results provide new leads in molecular mechanisms by which DHA can modulate inflammatory processes
Zeeman energy and spin relaxation in a one-electron quantum dot
We have measured the relaxation time, T1, of the spin of a single electron
confined in a semiconductor quantum dot (a proposed quantum bit). In a magnetic
field, applied parallel to the two-dimensional electron gas in which the
quantum dot is defined, Zeeman splitting of the orbital states is directly
observed by measurements of electron transport through the dot. By applying
short voltage pulses, we can populate the excited spin state with one electron
and monitor relaxation of the spin. We find a lower bound on T1 of 50
microseconds at 7.5 T, only limited by our signal-to-noise ratio. A continuous
measurement of the charge on the dot has no observable effect on the spin
relaxation.Comment: Replaced with the version published in Phys. Rev. Let
Selfoscillations of Suspended Carbon Nanotubes with a Deflection Sensitive Resistance under Voltage Bias
We theoretically investigate the electro-mechanics of a Suspended Carbon
Nanotube with a Deflection Sensitive Resistance subjected to a homogeneous
Magnetic Field and a constant Voltage Bias. We show that, (with the exception
of a singular case), for a sufficiently high magnetic field the
time-independent state of charge transport through the nanotube becomes
unstable to selfexcitations of the mechanical vibration accompanied by
oscialltions in the voltage drop and current across the nanotube.Comment: 4 pages, 1 figur
Pumping of vibrational excitations in a Coulomb blockaded suspended carbon nanotube
Low-temperature transport spectroscopy measurements on a suspended few-hole
carbon nanotube quantum dot are presented, showing a gate-dependent harmonic
excitation spectrum which, strikingly, occurs in the Coulomb blockade regime.
The quantized excitation energy corresponds to the scale expected for
longitudinal vibrations of the nanotube. The electronic transport processes are
identified as cotunnel-assisted sequential tunneling, resulting from
non-equilibrium occupation of the mechanical mode. They appear only above a
high-bias threshold at the scale of electronic nanotube excitations. We discuss
models for the pumping process that explain the enhancement of the
non-equilibrium occupation and show that it is connected to a subtle interplay
between electronic and vibrational degrees of freedom
Capacitive Spring Softening in Single-Walled Carbon Nanotube Nanoelectromechanical Resonators
We report the capacitive spring softening effect observed in single-walled
carbon nanotube (SWNT) nanoelectromechanical (NEM) resonators. The nanotube
resonators adopt dual-gate configuration with both bottom-gate and side-gate
capable of tuning the resonance frequency through capacitive coupling.
Interestingly, downward resonance frequency shifting is observed with
increasing side-gate voltage, which can be attributed to the capacitive
softening of spring constant. Furthermore, in-plane vibrational modes exhibit
much stronger spring softening effect than out-of-plan modes. Our dual-gate
design should enable the differentiation between these two types of vibrational
modes, and open up new possibility for nonlinear operation of nanotube
resonators.Comment: 12 pages/ 3 figure
The Diagnostic Value of microRNA Expression Analysis in Detecting Intraductal Papillomas in Patients with Pathological Nipple Discharge
Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid holds potential for distinguishing between breast diseases. This study aimed to compare miRNA expression levels between nipple fluids from patients with PND to identify possible relevant miRNAs that could differentiate between intraductal papillomas and no abnormalities in the breast tissue. Nipple fluid samples from patients with PND without radiological and pathological suspicion for malignancy who underwent a ductoscopy procedure were analyzed. We used univariate and multivariate regression analyses to identify nipple fluid miRNAs differing between pathologically confirmed papillomas and breast tissue without abnormalities. A total of 27 nipple fluid samples from patients with PND were included for miRNA expression analysis. Out of the 22 miRNAs examined, only miR-145-5p was significantly differentially expressed (upregulated) in nipple fluid from patients with an intraductal papilloma compared to patients showing no breast abnormalities (OR 4.76, p = 0.046), with a diagnostic accuracy of 92%. miR-145-5p expression in nipple fluid differs for intraductal papillomas and breast tissue without abnormalities and, therefore, has potential as a diagnostic marker to signal presence of papillomas in PND patients. However, further refinement and validation in clinical trials are necessary to establish its clinical applicability
Внутриартериальная химиотерапия в комбинированном лечении резектабельного рака желудка с метастазами в печень
В Донецком областном противоопухолевом центре разработан и внедрен способ катетеризации печеночной артерии при паллиативных операциях у больных раком желудка с метастазами в печень. По данному способу пролечено 56 больных резектабельным раком желудка с метастатическим поражением печени, что позволило увеличить продолжительность и улучшить качество жизни больных.У Донецькому обласному протипухлинному центрі розроблено та впроваджено спосіб катетеризації печінкової артерії при паліативних операціях у хворих на рак шлунку з метастазами в печінку. За цим способом проліковано 56 хворих на резектабельний рак шлунку з метастатичним ураженням печінки, що дало змогу збільшити тривалість і поліпшити якість життя хворих.A method of catheterization of hepatic artery at palliative surgery in patients with gastric cancer and metastases to the liver was worked out and introduced at Donetsk Regional Antitumor Center. This method was used in 56 patients with operable cancer of the stomach with metastases to the liver, which allowed increasing the duration and improving the quality of life of the patients
Performance of Monolayer Graphene Nanomechanical Resonators with Electrical Readout
The enormous stiffness and low density of graphene make it an ideal material
for nanoelectromechanical (NEMS) applications. We demonstrate fabrication and
electrical readout of monolayer graphene resonators, and test their response to
changes in mass and temperature. The devices show resonances in the MHz range.
The strong dependence of the resonant frequency on applied gate voltage can be
fit to a membrane model, which yields the mass density and built-in strain.
Upon removal and addition of mass, we observe changes in both the density and
the strain, indicating that adsorbates impart tension to the graphene. Upon
cooling, the frequency increases; the shift rate can be used to measure the
unusual negative thermal expansion coefficient of graphene. The quality factor
increases with decreasing temperature, reaching ~10,000 at 5 K. By establishing
many of the basic attributes of monolayer graphene resonators, these studies
lay the groundwork for applications, including high-sensitivity mass detectors
Hydrogen balloon transportation: A cheap and efficient mode to transport hydrogen
The chances of a global hydrogen economy becoming a reality have increased significantly since the COVID pandemic and the war in Ukraine, and for net zero carbon emissions. However, intercontinental hydrogen transport is still a major issue. This study suggests transporting hydrogen as a gas at atmospheric pressure in balloons using the natural flow of wind to carry the balloon to its destination. We investigate the average wind speeds, atmospheric pressure, and temperature at different altitudes for this purpose. The ideal altitudes to transport hydrogen with balloons are 10 km or lower, and hydrogen pressures in the balloon vary from 0.25 to 1 bar. Transporting hydrogen from North America to Europe at a maximum 4 km altitude would take around 4.8 days on average. Hydrogen balloon transportation cost is estimated at 0.08 USD/kg of hydrogen, which is around 12 times smaller than the cost of transporting liquified hydrogen from the USA to Europe. Due to its reduced energy consumption and capital cost, in some locations, hydrogen balloon transportation might be a viable option for shipping hydrogen compared to liquefied hydrogen and other transport technologies
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