Ocular injuries caused by improvised explosion devices-case series of patients seen in National Eye Centre, Kaduna Nigeria

Aim: To highlight the pattern of ocular injuries as a result of improvised explosive devises by insurgents in Kaduna metropolis.Background: Ocular trauma is a cause of blindness in approximately half a million people worldwide and many more have suffered partial loss of sight. Trauma is the most important cause of unilateral loss of vision, particularly in developing countries. An improvised explosive device, also known as a roadside bomb, is a homemade bomb constructed and deployed in ways other than in conventional military action. In line with the insurgency in parts of northern Nigeria, there is need to identify the common associated ocular injuries with the view to recommending preventive measures and providing adequate resources to managing the challenges.Methodology: Consecutive patients who presented with bomb blast associated ocular injuries and consented to the study from December 2011 through November 2012 were prospectively followed up. Demographic, clinical and operative data was entered into preformed questionnaire and analyzed with SPSS V16.Results: Seven eyes of five patients (2 bilateral) met the inclusion criteria with a mean age of 20 years (7-29 years), male to female ratio of 1.5: 1. Only one of the seven affected eyes had presenting VA of 6/60, 2 had NPL and 4 HM. Open globe injury was present in 3 eyes (1-ruptured, 2 corneal laceration) and retinal detachment in two eyes.Conclusion: Bomb blast explosion is associated with catastrophic blinding ocular pathology thus the need to providing needed equipment/manpower to contain it  and seek lasting solutions to the wave violent insurgency

Rauvolfia vomitoria Afzel. disrupts dentate gyrus cells

88-94Herbal remedy for neurological problems may have adverse effects, and could prove detrimental if not regulated properly. Rauvolfia vomitoria (RV) is a herb commonly associated with psychiatry management because of its antipsychotic and sedative properties. Here, we studied the effects of the root bark extract of R. vomitoria on the dentate gyrus of adult Wistar rats. Twenty four adult Wistar rats (220 g average) were divided into four groups (n=6); control (placebo), 200, 300 and 400 mg/kg RV root bark extract, respectively for 7 days. The animals were sacrificed 24 h after last administration, and the brains were processed for histology and immunoreactivity. Results showed hypertrophy and atrophy of granule cells in all 200, 300 and 400 mg/kg RV groups, respectively. There was increased neuron specific enolase and glial fibrillary acidic protein expressions in the 200 and 300 mg/kg RV groups, while these proteins expression were decreased in the 400 mg/kg RV group. These results suggest that RV cause dentate gyrus cell injury in a dose-dependent pattern, and may lead to degeneration and disruption of functions

Trend and Causes of Maternal Mortality in a Nigerian Tertiary Hospital: A 5-year Retrospective Study (2010-2014) at the University of Calabar Teaching Hospital, Calabar, Nigeria

BACKGROUND: Maternal mortality ratios (MMR) are still unacceptably high in many low-income countries especially in sub-Saharan Africa. MMR had been reported to have improved from an initial 3,026 per 100,000 live births in 1999 to 941 in 2009, at the University of Calabar Teaching Hospital (UCTH), Calabar, a tertiary health facility in Nigeria. Post-partum haemorrhage and hypertensive diseases of pregnancy have been the common causes of maternal deaths in the facility.AIM: This study was aimed at determining the trend in maternal mortality in the same facility, following institution of some facility-based intervention measures.METHODOLOGY: A retrospective study design was utilised with extraction and review of medical records of pregnancy-related deaths in UCTH, Calabar, from January 2010 to December 2014. The beginning of the review period coincided with the period the “Woman Intervention Trial†was set up to reduce maternal mortality in the facility. This trial consists of the use of Tranexamic acid for prevention of post-partum haemorrhage, as well as more proactive attendance to parturition.RESULTS: There were 13,605 live births and sixty-one (61) pregnancy-related deaths in UCTH during the study period. This yielded a facility Maternal Mortality Ratio of 448 per 100,000 live births. In the previous 11-year period of review, there was sustained the decline in MMR by 72.9% in the initial four years (from 793 in 2010 to 215 in 2013), with the onset of resurgence to 366 in the last year (2014). Mean age at maternal death was 27 ± 6.5 years, with most subjects (45, 73.8%) being within 20-34 years age group. Forty-eight (78.7%) were married, 26 (42.6%) were unemployed, and 33 (55.7%) had at least secondary level of education. Septic abortion (13, 21.3%) and hypertensive diseases of pregnancy (10, 16.4%) were the leading causes of death. Over three quarters (47, 77.0%) had not received care from any health facility. Most deaths (46, 75.5%) occurred between 24 and 97 hours of admission.CONCLUSION: Compared with previous trends, there has been a significant improvement in maternal mortality ratio in the study setting. There is also a significant change in the leading cause of maternal deaths, with septic abortion and hypertensive disease of pregnancy now replacing post-partum haemorrhage and puerperal sepsis that was previously reported. This success may be attributable to the institution of the Woman trial intervention which is still ongoing in other parts of the world. There is, however, need to sustain effort at a further reduction in MMR towards the attainment of set sustainable development goals (SDGs), through improvement in the provision of maternal health services in low-income countries

Tackling alcoholism and domestic violence in fisheries - a new opportunity to improve wellbeing for the most vulnerable people in global fisheries

The UN Sustainable Development Goals (SDGs) principle of ‘Leaving no one behind’ focusses global attention on the poorest and most vulnerable people. As different sectors grapple to engage meaningfully with this principle, we posit that greater consideration of social problems in fishing-dependent communities, such as alcoholism and domestic violence, presents an opportunity for fisheries governors to contribute to the SDGs mandate. We further argue that governing marine resources in ignorance of these problems can risk harming some of the most vulnerable people in fisheries. Using subjective wellbeing data from women living in two small-scale fishing communities in India and Sri Lanka, we demonstrate the prevalence and impact of alcoholism and domestic violence in fishing households. We further highlight how policies which restrict access to marine resources can undermine important coping strategies, in particular the ability of women to act as independent income-earners, exacerbating harm to already vulnerable women. A scoping review of the literature reveals that alcoholism and domestic violence are reported in certain fisheries around the world, and we theorise how this may relate to the nature of fishing life, and growing stresses regarding the future of fishing. Tackling the burdens of alcoholism and domestic violence in fisheries, where it is an issue, is an opportunity to improve wellbeing for men, women and their families. The paper concludes with tangible actions which marine resource governors could adopt to contribute to the ‘leave no one behind’ ethos

Vocational Education and the Development of Adult Learners in Nigeria Through Skills Acquisition Schemes

A number of persons in any society may not, in spite of the availability of chances for education, acquire formal education up to the level that would position them for sustained personal growth in paid employment or in self-employment. Also, the concept of life-long learning requires continuous exposure to methods and knowledge generally in the chosen trade or profession of the individual. Programmes are therefore designed to meet the needs of persons that did not acquire enough formal education or none at all as well as those that need to sustain learning for self-development. Skills acquisition programmes are therefore designed under structured programmes of adult education to meet the needs of adult learners. This paper reviews the concepts of adult education and skills acquisition, the latter as an aspect of adult education with emphasis on Nigeria. It reviews a case involving a tertiary institution in Nigeria as sponsored by petroleum producing companies. The paper highlights the need for greater emphasis on practice during training under skills acquisition

Towards a Technological Model for Effective Communication in Education: The Campus Radio Concept

Education as a concept can only be discussed in the context of communication. In theory and in practice, education implies transfer of knowledge which in simple terms is about coded information from one party that knows or custodies such information to another party that is the recipient of such information. Technology, seen as materials and as know-how, permeates all aspects of education, from the source (teacher or knowledge pool) to the receiver (student or learner) whether in formal or informal settings. This paper reviews the radio broadcasting system in Nigeria as a tool for mass communication. It presents a technology model for effective communication that can be applied in the specific area of radio broadcasting particularly in the developing country context where other aspects of information and communication technology are fairly rudimentary or grossly inadequate. It makes a case for compulsory Campus radio systems which are at present very few in institutions of higher learning in Nigeria because of the prohibitive cost of purchase, installation, maintenance, as well as paucity of technical personnel

Evaluation of rifampicin resistance and 81-bp rifampicin resistant determinant region of rpoB gene mutations of Mycobacterium tuberculosis detected with XpertMTB/Rif in Cross River State, Nigeria

AbstractObjective/backgroundWorld Health Organization tuberculosis (TB) indices from 2014 to 2016 showed that Nigeria had the 6th highest prevalence, 4th highest incidence, and the highest mortality rate globally. In efforts to improve TB care, the XpertMTB/Rif (GeneXpert) technology, Cepheid, Sunnyvale, California, USA, which has revolutionized TB detection with concomitant rifampicin-resistance molecular detection, was introduced in Cross River State, South–South Nigeria, in 2014. The GeneXpert uses molecular beacons to detect five overlapping 81-bp regions in the rpoB gene known as the Rifampicin Resistant Determinant Region (RRDR). These probes are represented as Probe A (507–511), Probe B (512–518), Probe C (518–523), Probe D (523–529), and Probe E (529–533). Mutations in this region have been shown to account for about 93% of resistance to rifampicin, which is the most important drug in tuberculosis treatment. The objective of this study was to determine the frequency of rifampicin resistance and the commonly associated probes for various rpoB gene mutations within the 81-bp RRDR of Mycobacterium tuberculosis in Cross River State, Nigeria.MethodWe collated and analyzed data from the 10 Xpert MTB/Rif sites in Cross River State from June 2014 to June 2016 and determined the frequency of mutations associated with different probes designated A–E, which represent the RRDR of rpoB gene. All centers use XpertMTB/Rif version G4.ResultIn total, 973 tuberculosis cases were detected from 4671 cases tested. Rif resistance was detected in 6.0% (58/973) of cases. Probe E mutations were the most common, seen in 60.3% (35/58); followed by Probe D, 17.2% (10/58); and Probe B, 13.8% (8/58). Probe A occurred in 3.4% (2/58). No Probe C mutation was seen. Multiple mutation combinations involving probes B and D occurred in 3.4% (2/58), while one isolate had triple site mutations involving A, D, and E. One isolate that at initial testing showed a Probe A mutation displayed a Probe D mutation when tested in another site prior to treatment enrollment.ConclusionIn our setting, 6.0% of tuberculosis isolates are rifampicin resistant. Mutations associated with probe E commonly due to codon 531 are the most predominant cause of rifampicin resistance. Mutations at probe C (codons 518–523) were uncommon. A change in mutation may have occurred in one of the patients

Supply Control, Demand Reduction or Harm Reduction? Developments and Directions For Drug Policy in Nigeria

Nigeria is the most populous country in Africa, and it is a transit country for the passage of drugs to Western countries. This has among other factors, led to an increasing level of illicit drug use despite a long history of punitive measures of drug control. Nigeria boasts of very punitive laws against both drug use and drug trafficking, which has been endorsed by external bodies such as the US DEA, but there are no harm reduction policies or services and very limited availability of treatment services. There is a need to legislate for demand reduction measures in the country to complement possession and trafficking legislation and the develop treatment services nationally before there is a large increase in HIV and other blood borne diseases. A model of community level treatment services is proposed to deliver services at a local accessible level using existing NGOs and volunteers