The Cosmic Microwave Background & Inflation, Then & Now

Boomerang, Maxima, DASI, CBI and VSA significantly increase the case for accelerated expansion in the early universe (the inflationary paradigm) and at the current epoch (dark energy dominance), especially when combined with data on high redshift supernovae (SN1) and large scale structure (LSS). There are ``7 pillars of Inflation'' that can be shown with the CMB probe, and at least 5, and possibly 6, of these have already been demonstrated in the CMB data: (1) a large scale gravitational potential; (2) acoustic peaks/dips; (3) damping due to shear viscosity; (4) a Gaussian (maximally random) distribution; (5) secondary anisotropies; (6) polarization. A 7th pillar, anisotropies induced by gravity wave quantum noise, could be too small. A minimal inflation parameter set, \omega_b,\omega_{cdm}, \Omega_{tot}, \Omega_Q,w_Q,n_s,\tau_C, \sigma_8}, is used to illustrate the power of the current data. We find the CMB+LSS+SN1 data give \Omega_{tot} =1.00^{+.07}_{-.03}, consistent with (non-baroque) inflation theory. Restricting to \Omega_{tot}=1, we find a nearly scale invariant spectrum, n_s =0.97^{+.08}_{-.05}. The CDM density, \Omega_{cdm}{\rm h}^2 =.12^{+.01}_{-.01}, and baryon density, \Omega_b {\rm h}^2 = >.022^{+.003}_{-.002}, are in the expected range. (The Big Bang nucleosynthesis estimate is 0.019\pm 0.002.) Substantial dark (unclustered) energy is inferred, \Omega_Q \approx 0.68 \pm 0.05, and CMB+LSS \Omega_Q values are compatible with the independent SN1 estimates. The dark energy equation of state, crudely parameterized by a quintessence-field pressure-to-density ratio w_Q, is not well determined by CMB+LSS (w_Q < -0.4 at 95% CL), but when combined with SN1 the resulting w_Q < -0.7 limit is quite consistent with the w_Q=-1 cosmological constant case.Comment: 20 pages, 8 figures, in Theoretical Physics, MRST 2002: A Tribute to George Libbrandt (AIP), eds. V. Elias, R. Epp, R. Myer

Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1-Infected Patients with Nucleoside Analogue Reverse-Transcriptase Inhibitor-Associated Lipoatrophy

BackgroundLong-term use of both zidovudine (AZT) and stavudine (d4T) is associated with lipoatrophy, but it occurs possibly through different mechanisms MethodsSurgical biopsy specimens of subcutaneous adipose tissue were obtained from 18 human immunodeficiency virus type 1 (HIV-1)-infected lipoatrophic patients (the LA+ group) who were treated with either zidovudine (the AZT+LA+ group; n=10) or stavudine (the d4T+LA+ group; n=8) and from 10 nonlipoatrophic HIV-1-infected patients (the LA− group) who received antiretroviral therapy. Mitochondrial DNA (mtDNA) copy numbers, gene expression, and immunohistochemistry data were analyzed ResultsmtDNA copy numbers were significantly reduced in the LA+ group, compared with the LA− group, and in the d4T+LA+ group, compared with the AZT+LA+ group. The ratio of mtDNA-encoded cytochrome COX3 to nuclear DNA-encoded COX4 expression was significantly lower in the LA+ group than in the LA− group. Compared with the LA− group, the LA+ group had significantly lower expression of genes involved in adipogenesis (SREBP1cand CEBPB) lipid (fatty acid synthase), and glucose (GLUT4) metabolism. Expression of genes involved in mitochondrial biogenesis (PGC1B) apoptosis (FAS) inflammation (IL1B) oxidative stress (PCNA and SOD1) and lamin B was significantly higher in the LA+ group than in the LA− group. The d4T+LA+ group had significantly lower expression of genes involved in mitochondrial biogenesis (POLG1) energy metabolism (the COX3/COX4 ratio), adipogenesis (SREBP1c and CEBPA) perilipin, and hexokinase than did the AZT+LA+ group. There were 7-fold more macrophages in adipose tissue specimens obtained from patients in the LA+ group, compared with the LA− group ConclusionsLipoatrophy is characterized by mtDNA depletion, inflammation, and signs of apoptosis. Changes were more profound in the d4T+LA+ group than in the AZT+LA+ grou

The Sunyaev-Zeldovich effect in CMB-calibrated theories applied to the Cosmic Background Imager anisotropy power at l > 2000

We discuss the nature of the possible high-l excess in the Cosmic Microwave Background (CMB) anisotropy power spectrum observed by the Cosmic Background Imager (CBI). We probe the angular structure of the excess in the CBI deep fields and investigate whether it could be due to the scattering of CMB photons by hot electrons within clusters, the Sunyaev-Zeldovich (SZ) effect. We estimate the density fluctuation parameters for amplitude, sigma_8, and shape, Gamma, from CMB primary anisotropy data and other cosmological data. We use the results of two separate hydrodynamical codes for Lambda-CDM cosmologies, consistent with the allowed sigma_8 and Gamma values, to quantify the expected contribution from the SZ effect to the bandpowers of the CBI experiment and pass simulated SZ effect maps through our CBI analysis pipeline. The result is very sensitive to the value of sigma_8, and is roughly consistent with the observed power if sigma_8 ~ 1. We conclude that the CBI anomaly could be a result of the SZ effect for the class of Lambda-CDM concordance models if sigma_8 is in the upper range of values allowed by current CMB and Large Scale Structure (LSS) data.Comment: Accepted by The Astrophysical Journal; 17 pages including 12 color figures. v2 matches accepted version. Additional information at http://www.astro.caltech.edu/~tjp/CBI

Optical creation of vibrational intrinsic localized modes in anharmonic lattices with realistic interatomic potentials

Using an efficient optimal control scheme to determine the exciting fields, we theoretically demonstrate the optical creation of vibrational intrinsic localized modes (ILMs) in anharmonic perfect lattices with realistic interatomic potentials. For systems with finite size, we show that ILMs can be excited directly by applying a sequence of femtosecond visible laser pulses at THz repetition rates. For periodic lattices, ILMs can be created indirectly via decay of an unstable extended lattice mode which is excited optically either by a sequence of pulses as described above or by a single picosecond far-infrared laser pulse with linearly chirped frequency. In light of recent advances in experimental laser pulse shaping capabilities, the approach is experimentally promising.Comment: 20 pages, 7 eps figures. Accepted, Phys. Rev.

Breathers in Josephson junction ladders: resonances and electromagnetic waves spectroscopy

We present a theoretical study of the resonant interaction between dynamical localized states (discrete breathers) and linear electromagnetic excitations (EEs) in Josephson junction ladders. By making use of direct numerical simulations we find that such an interaction manifests itself by resonant steps and various sharp switchings (voltage jumps) in the current-voltage characteristics. Moreover, the power of ac oscillations away from the breather center (the breather tail) displays singularities as the externally applied dc bias decreases. All these features can be mapped to the spectrum of EEs that has been derived analytically and numerically. Using an improved analysis of the breather tail, a spectroscopy of the EEs is developed. The nature of breather instability driven by localized EEs is established.Comment: 15 pages, 13 figure

Dust and gas in luminous infrared galaxies - results from SCUBA observations

We present new data taken at 850 $\mu$m with SCUBA at the JCMT for a sample of 19 luminous infrared galaxies. Fourteen galaxies were detected. We have used these data, together with fluxes at 25, 60 and 100 $\mu$m from IRAS, to model the dust emission. We find that the emission from most galaxies can be described by an optically thin, single temperature dust model with an exponent of the dust extinction coefficient ($k_\lambda \propto \lambda^{-\beta}$) of $\beta \simeq 1.5 - 2$. A lower $\beta\simeq 1$ is required to model the dust emission from two of the galaxies, Arp 220 and NGC 4418. We discuss various possibilities for this difference and conclude that the most likely is a high dust opacity. In addition, we compare the molecular gas mass derived from the dust emission, $M_{dust}$, with the molecular gas mass derived from the CO emission, $M_{CO}$, and find that $M_{CO}$ is on average a factor 3 higher than $M_{dust}$.Comment: 10 pages, 6 figures, latex, with MN-macros, accepted by MNRAS - revised version (changed flux values for some galaxies

Efficacy and tolerability of gemtuzumab ozogamicin (anti-CD33 monoclonal antibody, CMA-676, Mylotarg(®)) in children with relapsed/refractory myeloid leukemia

BACKGROUND: Gemtuzumab ozogamicin (GO) is a cytotoxic anti-CD33 monoclonal antibody that has given promising preliminary results in adult myeloid CD33+ AML. We conducted a retrospective multicenter study of 12 children treated with GO on a compassionate basis (median age 5.5 y). Three patients (2 MDS/AML, 1 JMML) were refractory to first-line treatment, 8 patients with de novo AML were in refractory first relapse, and one patient with de novo AML was in 2(nd )relapse after stem cell transplantation (SCT). CD33 expression exceeded 20% in all cases. METHODS: GO was administered alone, at a unit dose of 3–9 mg/m(2), once (3 patients), twice (3 patients), three (5 patients) or five times (1 patient). Mean follow-up was 128 days (8–585 d). RESULTS: There were three complete responses (25%) leading to further curative treatment (SCT). Treatment failed in the other nine patients, and only one patient was alive at the end of follow-up. NCI-CTC grade III/IV adverse events comprised hematological toxicity (n = 12), hypertransaminasemia (n = 2), allergy and hyperbilirubinemia (1 case each). There was only one major adverse event (grade IV allergy). No case of sinusoidal obstruction syndrome occurred. CONCLUSION: These results warrant a prospective trial of GO in a larger population of children with AML

Discrete breathers in classical spin lattices

Discrete breathers (nonlinear localised modes) have been shown to exist in various nonlinear Hamiltonian lattice systems. In the present paper we study the dynamics of classical spins interacting via Heisenberg exchange on spatial $d$-dimensional lattices (with and without the presence of single-ion anisotropy). We show that discrete breathers exist for cases when the continuum theory does not allow for their presence (easy-axis ferromagnets with anisotropic exchange and easy-plane ferromagnets). We prove the existence of localised excitations using the implicit function theorem and obtain necessary conditions for their existence. The most interesting case is the easy-plane one which yields excitations with locally tilted magnetisation. There is no continuum analogue for such a solution and there exists an energy threshold for it, which we have estimated analytically. We support our analytical results with numerical high-precision computations, including also a stability analysis for the excitations.Comment: 15 pages, 12 figure