Search for the onset of baryon anomaly at RHIC-PHENIX

The baryon production mechanism at the intermediate $p_T$ (2 - 5 GeV/$c$) at RHIC is still not well understood. The beam energy scan data in Cu+Cu and Au+Au systems at RHIC may provide us a further insight on the origin of the baryon anomaly and its evolution as a function of $\sqrt{s_{NN}}$. In 2005 RHIC physics program, the PHENIX experiment accumulated the first intensive low beam energy data in Cu+Cu collisions. We present the preliminary results of identified charged hadron spectra in Cu+Cu at $\sqrt{s_{NN}}$ = 22.5 and 62.4 GeV using the PHENIX detector. The centrality and beam energy dependences of (anti)proton to pion ratios and the nuclear modification factors for charged pions and (anti)protons are presented.Comment: 5 pages, 9 figures, proceedings for Hot Quarks 2006 workshop, Villasimius, Sardinia, Italy, May 15 - 20, 2006. Proceedings of the conference will be published in The European Physical Journal

A large-scale, near-sea level, silicic caldera-forming eruption in Efate? An alternative model for the 1 Ma Efate Pumice Formation, Vanuatu, SW-Pacific

No abstract availabl

Novel approach for efficient predictions properties of large pool of nanomaterials based on limited set of species: nano-read-across

Creating suitable chemical categories and developing read-across methods, supported by quantum mechanical calculations, can be an effective solution to solving key problems related to current scarcity of data on the toxicity of various nanoparticles. This study has demonstrated that by applying a nano-read-across, the cytotoxicity of nano-sized metal oxides could be estimated with a similar level of accuracy as provided by quantitative structure-activity relationship for nanomaterials (nano-QSAR model(s)). The method presented is a suitable computational tool for the preliminary hazard assessment of nanomaterials. It also could be used for the identification of nanomaterials that may pose potential negative impact to human health and the environment. Such approaches are especially necessary when there is paucity of relevant and reliable data points to develop and validate nano-QSAR model

Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance.

BackgroundPatients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance.MethodsTumor tissue from ten patients with advanced BRAF mutation-positive melanoma who achieved partial response (PR) or complete response (CR) on BRAF and/or MEK inhibitors was analyzed using next generation sequencing (NGS) assay. Genomic libraries were captured for 3230 exons in 182 cancer-related genes plus 37 introns from 14 genes often rearranged in cancer and sequenced to average median depth of 734X with 99% of bases covered >100X.ResultsThree of the ten patients (median number of prior therapies = 2) attained prolonged CR (duration = 23.6+ to 28.7+ months); seven patients achieved either a PR or a short-lived CR. One patient who achieved CR ongoing at 28.7+ months and had tissue available close to the time of initiating BRAF inhibitor therapy had only a BRAF mutation. Abnormalities in addition to BRAF mutation found in other patients included: mutations in NRAS, APC and NF1; amplifications in BRAF, aurora kinase A, MYC, MITF and MET; deletions in CDKN2A/B and PAX5; and, alterations in RB1 and ATM. Heterogeneity between patients and molecular evolution within patients was noted.ConclusionNGS identified potentially actionable DNA alterations that could account for resistance in patients with BRAF mutation-positive advanced melanoma who achieved a PR or CR but whose tumors later progressed. A subset of patients with advanced melanoma may harbor only a BRAF mutation and achieve a durable CR on BRAF pathway inhibitors

Variation in oxytocin is related to variation in affiliative behavior in monogamous, pairbonded tamarins

Oxytocin plays an important role in monogamous pairbonded female voles, but not in polygamous voles. Here we examined a socially monogamous cooperatively breeding primate where both sexes share in parental care and territory defense for within species variation in behavior and female and male oxytocin levels in 14 pairs of cotton-top tamarins (Saguinus oedipus). In order to obtain a stable chronic assessment of hormones and behavior, we observed behavior and collected urinary hormonal samples across the tamarins’ 3-week ovulatory cycle. We found similar levels of urinary oxytocin in both sexes. However, basal urinary oxytocin levels varied 10-fold across pairs and pair-mates displayed similar oxytocin levels. Affiliative behavior (contact, grooming, sex) also varied greatly across the sample and explained more than half the variance in pair oxytocin levels. The variables accounting for variation in oxytocin levels differed by sex. Mutual contact and grooming explained most of the variance in female oxytocin levels, whereas sexual behavior explained most of the variance in male oxytocin levels. The initiation of contact by males and solicitation of sex by females were related to increased levels of oxytocin in both. This study demonstrates within-species variation in oxytocin that is directly related to levels of affiliative and sexual behavior. However, different behavioral mechanisms influence oxytocin levels in males and females and a strong pair relationship (as indexed by high levels of oxytocin) may require the activation of appropriate mechanisms for both sexes

Muscle-tendon morphology and function following long-term exposure to repeated and strenuous mechanical loading

We mapped structural and functional characteristics of muscle‐tendon units in a population exposed to very long‐term routine overloading. Twenty‐eight military academy cadets (age = 21.00 ± 1.1 years; height = 176.1 ± 4.8 cm; mass = 73.8 ± 7.0 kg) exposed for over 24 months to repetitive overloading were profiled via ultrasonography with a senior subgroup of them (n = 11; age = 21.4 ± 1.0 years; height = 176.5 ± 4.8 cm; mass = 71.4 ± 6.6 kg) also tested while walking and marching on a treadmill. A group of eleven ethnicity‐ and age‐matched civilians (age = 21.6 ± 0.7 years; height = 176.8 ± 4.3 cm; mass = 74.6 ± 5.6 kg) was also profiled and tested. Cadets and civilians exhibited similar morphology (muscle and tendon thickness and cross‐sectional area, pennation angle, fascicle length) in 26 out of 29 sites including the Achilles tendon. However, patellar tendon thickness along the entire tendon was greater (P < .05) by a mean of 16% for the senior cadets compared with civilians. Dynamically, cadets showed significantly smaller ranges of fascicle length change and lower shortening velocity in medial gastrocnemius during walking (44.0% and 47.6%, P < .05‐.01) and marching (27.5% and 34.3%, P < .05‐.01) than civilians. Furthermore, cadets showed lower normalized soleus electrical activity during walking (22.7%, P < .05) and marching (27.0%, P < .05). Therefore, 24‐36 months of continuous overloading, primarily occurring under aerobic conditions, leads to more efficient neural and mechanical behavior in the triceps surae complex, without any major macroscopic alterations in key anatomical structures

STRENGTH AND POWER PREDICTORS OF SPORTS SPEED

ABSTRACT. Cronin, J.B., and K.T. Hansen. Strength and power predictors of sports speed. J. Strength Cond. Res. 19(2)-.349-357. 2005.-For many sporting activities, initial speed rather than maximal speed would he considered of greater importance to successful performance. The purpose of this study was to identify the relationship between strength and power and measures of first-step quickness (5-m time), acceleration (10-m time), and maximal speed (30-m time). The maximal strength (3 repetition maximum [3RM]), power (30-kg jump squat, countermovement, and drop jumps), isokinetic strength measures (hamstring and quadriceps peak torques and ratios at 60°.s&quot;&apos; and 300°.s&quot;&apos;) and 5-m, 10-m, and 30-m sprint times of 26 part-time and full-time professional rugby league players (age 23.2 ± 3.3 years) were measured. To examine the importance of the strength and power measures on sprint performance, a correlational approach and a comparison between means of the fastest and slowest players was used. The correlations hetween the 3RM, drop jump, isokinetic strength measures, and the 3 measures of sport speed were nonsignificant. Correlations hetween the jump squat (height and relative power output) and countermovement jump height and the 3 speed measures were significant (r = -0.43 to -0.66, p &lt; 0.05). The squat and countermovement jump heights as well as squat jump relative power output were the only variahles found to he significantly greater in the fast players. It was suggested that improving the power to weight ratio as well as plyometric training involving countermovement and loaded jump-squat training may he more effective for enhancing sport speed in elite players

Heavy quarkonium 2S states in light-front quark model

We study the charmonium 2S states $\psi'$ and $\eta_c'$, and the bottomonium 2S states $\Upsilon'$ and $\eta_b'$, using the light-front quark model and the 2S state wave function of harmonic oscillator as the approximation of the 2S quarkonium wave function. The decay constants, transition form factors and masses of these mesons are calculated and compared with experimental data. Predictions of quantities such as Br$(\psi' \to \gamma \eta_c')$ are made. The 2S wave function may help us learn more about the structure of these heavy quarkonia.Comment: 5 latex pages, final version for journal publicatio

Cronin Effect in Hadron Production off Nuclei

Recent data from RHIC for high-$p_T$ hadrons in gold-gold collisions raised again the long standing problem of quantitatively understanding the Cronin effect, i.e. nuclear enhancement of high-$p_T$ hadrons due to multiple interactions in nuclear matter. In nucleus-nucleus collisions this effect has to be reliably calculated as baseline for a signal of new physics in high-$p_T$ hadron production. The only possibility to test models is to compare with available data for $pA$ collisions, however, all existing models for the Cronin effect rely on a fit to the data to be explained. We develop a phenomenological description based on the light-cone QCD-dipole approach which allows to explain available data without fitting to them and to provide predictions for $pA$ collisions at RHIC and LHC. We point out that the mechanism causing Cronin effect drastically changes between the energies of fixed target experiments and RHIC-LHC. High-$p_T$ hadrons are produced incoherently on different nucleons at low energies, whereas the production amplitudes interfere if the energy is sufficiently high.Comment: the final version to appear in Phys. Rev. Let

Strong rescattering in K-> 3pi decays and low-energy meson dynamics

We present a consistent analysis of final state interactions in ${K\rightarrow 3\pi}$ decays in the framework of Chiral Perturbation Theory. The result is that the kinematical dependence of the rescattering phases cannot be neglected. The possibility of extracting the phase shifts from future $K_S-K_L$ interference experiments is also analyzed.Comment: 14 pages in RevTex, 3 figures in postscrip