New Observations at the Slate Islands Impact Structure, Lake Superior

Slate Islands, a group of 2 large and several small islands, is located in northern Lake Superior, approximately 10 km south of Terrace Bay. Shatter cones, breccias and shock metamorphic features provide evidence that the Slate Islands Structure was formed as a result of asteroid or comet impact. Most of the island group is believed to represent the central uplift of a complex impact crater. The structure possibly has a diameter of about 32 km. For Sage (1978, 1991) shock metamorphic features, shatter cones and pervasive rock brecciation are the results of diatreme activity. The present investigations represent the second year of a co-operative study of the Lunar and Planetary Institute, Houston, Texas and the Field Services Section (Northwest) of the Ontario Geological Survey. The objective of this investigation is to come to a better understanding of the formation of mid-size impact structures on Earth and the planets of the solar system. Impact processes played a fundamental role in the formation of the planets and the evolution of life on Earth. Meteorite and comet impacts are not a phenomenon of the past. Last year, more than 20 pieces of the Shoemaker-Levy 9 impacted on Jupiter and the Tunguska comet impacted in Siberia in the early years of this century. The study of impact processes is a relatively young part of geoscience and much is still to be learnt by detailed field and laboratory investigations. The State Islands Structure has been selected for the present detailed investigations because of the excellent shoreline outcrops of rock units related to the impact. The structure is a complex impact crater that has been eroded so that important lithological and structural elements are exposed. We know of no other mid-size terrestrial impact structure with equal or better exposures. In this publication we present preliminary results of our 1994 and 1995 field and laboratory investigations. We have tentatively identified a few impact melt and a considerable number of suevite occurrences

Clastic Breccias at the Slates Islands Complex Impact Structure, Northern Lake Superior

About 150 impact craters are known on Earth and each year several structures are added to this number. The general geology of the Slate Islands archipelago has been described by Sage (1991) and a short summary based on Sage's work is given in Dressler et al. (1995). The reader is referred to these publications for information on the bedrock geology of the island group. Early studies on the Slate Islands impact structure include: Halls and Grieve (1976), Grieve and Robertson (1976) and Stesky and Halls (1983). In this report, we provide a summary of the impact process as presently understood. We also present some of the results of our laboratory investigations conducted in 1995 and 1996. We describe in some detail the various clastic breccias encountered on the islands during our 1994 and 1995 field work and relate them to the various phases of the impact process. A more encompassing treatise on the breccias has been submitted for publication. (Dressler and Sharpton 1996)

Analyzing the footprints of near-surface aqueous turbulence: An image processing-based approach

In this contribution, a detailed investigation of surface thermal patterns on the water surface is presented, with wind speeds ranging from 1 to 7 m s  − 1 and various surface conditions. Distinct structures can be observed on the surface—small-scale short-lived structures termed fish scales and larger-scale cold streaks that are consistent with the footprints of Langmuir circulations. The structure of the surface heat pattern depends strongly on wind-induced stress. Consistent behavior regarding the spacing of cold streaks can be observed in a range of laboratory facilities when expressed as a function of water-sided friction velocity, u * . This behavior systematically decreased until a point of saturation at u *  = 0.7 cm/s. We present a new image processing-based approach to the analysis of the spacing of cold streaks based on a machine learning approach to classify the thermal footprints of near-surface turbulence. Comparison is made with studies of Langmuir circulation and the following key points are found. Results suggest a saturation in the tangential stress, anticipating that similar behavior will be observed in the open ocean. A relation to Langmuir numbers shows that thermal footprints in infrared images are consistent with Langmuir circulations and depend strongly on wind wave conditions

The Automated Inspection of Opaque Liquid Vaccines

In the pharmaceutical industry the screening of opaque vaccines containing suspensions is currently a manual task carried out by trained human visual inspectors. We show that deep learning can be used to effectively automate this process. A moving contrast is required to distinguish anomalies from other particles, reflections and dust resting on a vial's surface. We train 3D-ConvNets to predict the likelihood of 20-frame video samples containing anomalies. Our unaugmented dataset consists of hand-labelled samples, recorded using vials provided by the HAL Allergy Group, a pharmaceutical company. We trained ten randomly initialized 3D-ConvNets to provide a benchmark, observing mean AUROC scores of 0.94 and 0.93 for positive samples (containing anomalies) and negative (anomaly-free) samples, respectively. Using Frame-Completion Generative Adversarial Networks we: (i) introduce an algorithm for computing saliency maps, which we use to verify that the 3D-ConvNets are indeed identifying anomalies; (ii) propose a novel self-training approach using the saliency maps to determine if multiple networks agree on the location of anomalies. Our self-training approach allows us to augment our data set by labelling 217,888 additional samples. 3D-ConvNets trained with our augmented dataset improve on the results we get when we train only on the unaugmented dataset.Comment: 8 pages, 5 Figures, 3 Tables, ECAI 2020 Conference Proceeding

TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells

BACKGROUND: TSPY is a repeated gene mapped to the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY), the only oncogenic locus on this male-specific chromosome. Elevated levels of TSPY have been observed in gonadoblastoma specimens and a variety of other tumor tissues, including testicular germ cell tumors, prostate cancer, melanoma, and liver cancer. TSPY contains a SET/NAP domain that is present in a family of cyclin B and/or histone binding proteins represented by the oncoprotein SET and the nucleosome assembly protein 1 (NAP1), involved in cell cycle regulation and replication. METHODS: To determine a possible cellular function for TSPY, we manipulated the TSPY expression in HeLa and NIH3T3 cells using the Tet-off system. Cell proliferation, colony formation assays and tumor growth in nude mice were utilized to determine the TSPY effects on cell growth and tumorigenesis. Cell cycle analysis and cell synchronization techniques were used to determine cell cycle profiles. Microarray and RT-PCR were used to investigate gene expression in TSPY expressing cells. RESULTS: Our findings suggest that TSPY expression increases cell proliferation in vitro and tumorigenesis in vivo. Ectopic expression of TSPY results in a smaller population of the host cells in the G(2)/M phase of the cell cycle. Using cell synchronization techniques, we show that TSPY is capable of mediating a rapid transition of the cells through the G(2)/M phase. Microarray analysis demonstrates that numerous genes involved in the cell cycle and apoptosis are affected by TSPY expression in the HeLa cells. CONCLUSION: These data, taken together, have provided important insights on the probable functions of TSPY in cell cycle progression, cell proliferation, and tumorigenesis

Molecular Mining of Alleles in Water Buffalo Bubalus bubalis and Characterization of the TSPY1 and COL6A1 Genes

discovered in the process. gene in water buffalo, which localized to the Y chromosome.The MASA approach enabled us to identify several genes, including two of clinical significance, without screening an entire cDNA library. Genes identified with TGG repeats are not part of a specific family of proteins and instead are distributed randomly throughout the genome. Genes showing elevated expression in the testes and spermatozoa may prove to be potential candidates for in-depth characterization. Furthermore, their possible involvement in fertility or lack thereof would augment animal biotechnology