The use of soft lithography to reproduce snail-like movement by creating pressure gradients in thin films

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.Includes bibliographical references (p. 18-20).By imitating nature, man finds ways to expand his capacities. To achieve this aim, he often takes natures designs, simplifies them to their most basic principles and then works in a retrograde fashion to add back the complexity originally stripped away to make the first discoveries. This thesis is based on previous work done on modeling snail movement on a macroscopic scale using a motor driven wave propagation machine. This project scaled down the mechanism to a size more commonly found in nature. This downscaling required a new method for producing waves. Peristaltic pumping achieved through the use of soft-lithography and pneumatics was the method chosen. This combination of ideas proved challenging for several reasons. First, the pumping method had previously only been used with one channel per pneumatic input, whereas the snail required each input to feed a multitude of branching channels creating a more complicated fluid dynamics problem. Second, the snail waves were downscaled from a continuous sinusoid to the three phase stepping mechanism of the peristaltic pump. Each three-phase cycle was considered equivalent to one wavelength. Thus, after creating a design that could move, the ratio between the traveling wavelength speed and subsequent net movement were compared to the aforementioned mathematical model. The model's ratio was 0.56 net/wave velocity. The actual ratio was .05 net/wave velocity. The difference by an order of magnitude could be attributed to the discontinuity of the pumping mechanism as opposed to the continuous nature of an actual traveling wave.by Pey-Hua B. Hwang.S.B

Photovoltaic nanopillar radial junction diode architecture enhanced by integrating semiconductor quantum dot nanocrystals as light harvesters

We propose and demonstrate colloidal quantum dot hybridized, radial p-n junction based, nanopillar solar cells with photovoltaic performance enhanced by intimately integrating nanocrystals to serve as light harvesting agents around the light trapping pillars. By furnishing Si based nanopillar photovoltaic diodes with CdSe quantum dots, we experimentally showed up to sixfold enhancement in UV responsivity and ∼13% enhancement in overall solar conversion efficiency. The maximum responsivity enhancement achieved by incorporation of nanocrystals in the nanopillar architecture is found to be spectrally more than four times larger than the responsivity enhancement obtained using planar architecture of the same device. © 2010 American Institute of Physics

Generating Time-Varying Road Network Data Using Sparse Trajectories

While research on time-varying graphs has attracted recent attention, the research community has limited or no access to real datasets to develop effective algorithms and systems. Using noisy and sparse GPS traces from vehicles, we develop a time-varying road network data set where edge weights differ over time. We present our methodology and share this dataset, along with a graph manipulation tool. We estimate the traffic conditions using the sparse GPS data available by characterizing the sparsity issues and assessing the properties of travel sequence data frequency domain. We develop interpolation methods to complete the sparse data into a complete graph dataset with realistic time-varying edge values. We evaluate the performance of time-varying and static shortest path solutions over the generated dynamic road network. The shortest paths using the dynamic graph produce very different results than the static version. We provide an independent Java API and a graph database to analyze and manipulate the generated time-varying graph data easily, not requiring any knowledge about the inners of the graph database system. We expect our solution to support researchers to pursue problems of time-varying graphs in terms of theoretical, algorithmic, and systems aspects. The data and Java API are available at: http://elif.eser.bilkent.edu.tr/roadnetwork. © 2016 IEEE

Understanding and predicting trends in urban freight transport

Among different components of urban mobility, urban freight transport is usually considered as the least sustainable. Limited traffic infrastructures and increasing demands in dense urban regions lead to frequent delivery runs with smaller freight vehicles. This increases the traffic in urban areas and has negative impacts upon the quality of life in urban populations. Data driven optimizations are essential to better utilize existing urban transport infrastructures and to reduce the negative effects of freight deliveries for the cities. However, there is limited work and data driven research on urban delivery areas and freight transportation networks. In this paper, we collect and analyse data on urban freight deliveries and parking areas towards an optimized urban freight transportation system. Using a new check-in based mobile parking system for freight vehicles, we aim to understand and optimize freight distribution processes. We explore the relationship between areas' availability patterns and underlying traffic behaviour in order to understand the trends in urban freight transport. By applying the detected patterns we predict the availabilities of loading/unloading areas, and thus open up new possibilities for delivery route planning and better managing of freight transport infrastructures. © 2017 IEEE

Light-harvesting semiconductor quantum dot nanocrystals integrated on photovoltaic radial junction nanopillars

[No abstract available

Length Effects on the Reliability of Dual-Damascene Cu Interconnects

The effects of interconnect length on the reliability of dual-damascene Cu metallization have been investigated. As in Al-based interconnects, the lifetimes of Cu lines increase with decreasing length. However, unlike Al-based interconnects, no critical length exists, below which all Cu lines are âimmortal’. Furthermore, we found multi-modal failure statistics for long lines, suggesting multiple failure mechanisms. Some long Cu interconnect segments have very large lifetimes, whereas in Al segments, lifetimes decrease continuously with increasing line length. It is postulated that the large lifetimes observed in long Cu lines result from liner rupture at the bottom of the vias, which allows continuous flow of Cu between the two bond pads. As a consequence, the average lifetimes of short lines and long lines can be higher than those of lines with intermediate lengths.Singapore-MIT Alliance (SMA

A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

The phosphomimetic mutation S82D in the cancer-associated, FAD-dependent human NADP(H):quinone oxidoreductase 1 (hNQO1) causes a decrease in flavin-adenine dinucleotide-binding affinity and intracellular stability. We test in this work whether the evolutionarily recent neutral mutation R80H in the vicinity of S82 may alter the strong functional effects of S82 phosphorylation through electrostatic interactions. We show using biophysical and bioinformatic analyses that the reverse mutation H80R prevents the effects of S82D phosphorylation on hNQO1 by modulating the local stability. Consistently, in rat NQO1 (rNQO1) which contains R80, the effects of phosphorylation were milder, resembling the behaviour found in hNQO1 when this residue was humanized in rNQO1 (by the R80H mutation). Thus, apparently neutral and evolutionarily divergent mutations may determine the functional response of mammalian orthologues towards phosphorylation. © 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societie

Investigation of the Fundamental Reliability Unit for Cu Dual-Damascene Metallization

An investigation has been carried out to determine the fundamental reliability unit of copper dual-damascene metallization. Electromigration experiments have been carried out on straight via-to-via interconnects in the lower metal (M1) and the upper metal (M2), and in a simple interconnect tree structure consisting of straight via-to-via line with an extra via in the middle of the line (a "dotted-I"). Multiple failure mechanisms have been observed during electromigration testing of via-to-via Cu interconnects. The failure times of the M2 test structures are significantly longer than that of identical M1 structures. It is proposed that this asymmetry is the result of a difference in the location of void formation and growth, which is believed to be related to the ease of electromigration-induced void nucleation and growth at the Cu/Si₃N₄ interface. However, voids were also detected in the vias instead of in the Cu lines for some cases of early failure of the test lines. These early failures are suspected to be related to the integrity and reliability of the Cu via. Different magnitudes and directions of electrical current were applied independently in two segments of the interconnect tree structure. As with Al-based interconnects, the reliability of a segment in this tree strongly depends on the stress conditions of the connected segment. Beyond this, there are important differences in the results obtained under similar test conditions for Al-based and Cu-based interconnect trees. These differences are thought to be associated with variations in the architectural schemes of the two metallizations. The absence of a conducting electromigration-resistant overlayer in Cu technology allows smaller voids to cause failure in Cu compared to Al. Moreover, the Si₃N₄ overlayer that serves as an interlevel diffusion barrier provides sites for easy nucleation of voids and also provides a high diffusivity path for electromigration. The results reported here suggest that while segments are not the fundamental reliability unit for circuit-level reliability assessments for Al or Cu, vias, rather than trees, might be the appropriate fundamental units for the assessment of Cu reliability.Singapore-MIT Alliance (SMA

PM speciation and sources in Mexico during the MILAGRO-2006 Campaign

International audienceLevels of PM10, PM2.5 and PM1 and chemical speciation of PM10 and PM2.5 were measured during the MILAGRO campaign (1st to 31st March 2006, but extended in some cases until 6th April) at four urban, one suburban, two rural background and two rural sites, with different degree of industrial influence, in the Mexico City Metropolitan Area (MCMA) and adjacent regions. PM10 and PM2.5 daily levels varied between 50?56?g/m3 and 24?46?g/m3 at the urban sites, 22?35?g/m3 and 13?25?g/m3 at the rural sites, and 75?g/m3 and 31?g/m3 at the industrial hotspot, lower than those recorded at some Asian mega-cities and similar to those recorded at other Latin American cities. At the urban sites, hourly PM2.5 and PM1 concentrations showed a marked impact of road traffic emissions (at rush hours), with levels of coarse PM remaining elevated during daytime. At the suburban and rural sites different PM daily patterns were registered according to the influence of the pollution plume from MCMA, and also of local soil resuspension. The speciation studies showed that mineral matter accounted for 25?27% of bulk PM10 at the urban sites and a higher proportion (up to 43%) at the suburban and rural sites. This pattern is repeated in PM2.5, with 15% at urban and 28% at suburban and rural sites. Carbonaceous compounds accounted for a significant proportion at the urban and industrial sites (32?46% in PM10, and 51?55% in PM2.5), markedly reduced at the suburban and rural sites (16?23% in PM10, and 30% in PM2.5). The secondary inorganic aerosols accounted for 10?20% of bulk PM10 at urban, suburban, rural and industrial sites, with a higher proportion (40%) at the industrial background site. A relatively high proportion of nitrate in rural sites was present in the coarse fraction. Typically anthropogenic elements (As, Cr, Zn, Cu, Pb, Sn, Sb, Ba, among others) showed considerably high levels at the urban sites; however levels of particulate Hg and crustal trace elements (Rb, Ti, La, Sc, Ga) were generally higher at the suburban site. Principal component analysis identified three major common factors: crustal, regional background and road traffic. Moreover, some specific factors were obtained for each site