La culture du vanillier

We use observations of ice sheet surface motion from a Global Positioning System network operating from 2006 to 2014 around North Lake in west Greenland to investigate the dynamical response of the Greenland Ice Sheet's ablation area to interannual variability in surface melting. We find no statistically significant relationship between runoff season characteristics and ice flow velocities within a given year or season. Over the 7 year time series, annual velocities at North Lake decrease at an average rate of −0.9 ± 1.1 m yr−2, consistent with the negative trend in annual velocities observed in neighboring regions over recent decades. We find that net runoff integrated over several preceding years has a negative correlation with annual velocities, similar to findings from the two other available decadal records of ice velocity in western Greenland. However, we argue that this correlation is not necessarily evidence for a direct hydrologic mechanism acting on the timescale of multiple years but could be a statistical construct. Finally, we stress that neither the decadal slowdown trend nor the negative correlation between velocity and integrated runoff is predicted by current ice-sheet models, underscoring that these models do not yet capture all the relevant feedbacks between runoff and ice dynamics needed to predict long-term trends in ice sheet flow

Europe as a multilevel federation

Peer reviewedPublisher PD

Pattern formation in directional solidification under shear flow. I: Linear stability analysis and basic patterns

An asymptotic interface equation for directional solidification near the absolute stabiliy limit is extended by a nonlocal term describing a shear flow parallel to the interface. In the long-wave limit considered, the flow acts destabilizing on a planar interface. Moreover, linear stability analysis suggests that the morphology diagram is modified by the flow near the onset of the Mullins-Sekerka instability. Via numerical analysis, the bifurcation structure of the system is shown to change. Besides the known hexagonal cells, structures consisting of stripes arise. Due to its symmetry-breaking properties, the flow term induces a lateral drift of the whole pattern, once the instability has become active. The drift velocity is measured numerically and described analytically in the framework of a linear analysis. At large flow strength, the linear description breaks down, which is accompanied by a transition to flow-dominated morphologies, described in a companion paper. Small and intermediate flows lead to increased order in the lattice structure of the pattern, facilitating the elimination of defects. Locally oscillating structures appear closer to the instability threshold with flow than without.Comment: 20 pages, Latex, accepted for Physical Review

Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy

© Springer-Verlag GmbH Germany, part of Springer Nature 2018Background: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the time of initial transurethral resection of bladder tumor (TURBT) has an oncological impact on the response to NAC prior to radical cystectomy. Patients and methods: Patients were identified retrospectively from 19 centers who received at least three cycles of NAC or induction chemotherapy for cT2-T4aN0-3M0 urothelial carcinoma of the bladder followed by radical cystectomy between 2000 and 2013. The primary and secondary outcomes were pathological response and overall survival, respectively. Multivariable analysis was performed to determine the independent predictive value of CIS on these outcomes. Results: Of 1213 patients included in the analysis, 21.8% had concomitant CIS. Baseline clinical and pathologic characteristics of the ‘CIS’ versus ‘no-CIS’ groups were similar. The pathological response did not differ between the two arms when response was defined as pT0N0 (17.9% with CIS vs 21.9% without CIS; p = 0.16) which may indicate that patients with CIS may be less sensitive to NAC or ≤ pT1N0 (42.8% with CIS vs 37.8% without CIS; p = 0.15). On Cox regression model for overall survival for the cN0 cohort, the presence of CIS was not associated with survival (HR 0.86 (95% CI 0.63–1.18; p = 0.35). The presence of LVI (HR 1.41, 95% CI 1.01–1.96; p = 0.04), hydronephrosis (HR 1.63, 95% CI 1.23–2.16; p = 0.001) and use of chemotherapy other than ddMVAC (HR 0.57, 95% CI 0.34–0.94; p = 0.03) were associated with shorter overall survival. For the whole cohort, the presence of CIS was also not associated with survival (HR 1.05 (95% CI 0.82–1.35; p = 0.70). Conclusion: In this multicenter, real-world cohort, CIS status at TURBT did not affect pathologic response to neoadjuvant or induction chemotherapy. This study is limited by its retrospective nature as well as variability in chemotherapy regimens and surveillance regimens.Peer reviewedFinal Accepted Versio

CHERCAM: A Cherenkov imager for the CREAM experiment

International audienceThe CREAM experiment (Cosmic Ray Energetics and Mass) is dedicated to the measurement of the energy spectrum of nuclear elements in cosmic rays, over the range 10$^{12}$ to 10$^{15}$ eV. The individual elements separation, which is a key feature of CREAM, requires instruments with strong identification capabilities. A proximity focused type of Cherenkov imager, CHERCAM (CHERenkov CAMera), providing both a good signature of downgoing Z=1 particles and good single element separation through the whole range of nuclear charges [Buénerd et al. 28th ICRC, Tsukuba, OG 1.5, 2003, p. 2157], is under development. After a brief introduction, the main features and the construction status of the CHERCAM are being summarized

Reading Between the (Spectral) Lines: Magellan/IMACS spectroscopy of the Ultra-faint Dwarf Galaxies Eridanus IV and Centaurus I

We present a spectroscopic analysis of Eridanus IV (Eri IV) and Centaurus I (Cen I), two ultra-faint dwarf galaxies of the Milky Way. Using IMACS/Magellan spectroscopy, we identify 28 member stars of Eri IV and 34 member stars of Cen I. For Eri IV, we measure a systemic velocity of $v_{sys} = -31.5^{+1.3}_{-1.2}\:\mathrm{km\:s^{-1}}$ and velocity dispersion $\sigma_{v}= 6.1^{+1.2}_{-0.9}\:\mathrm{km\:s^{-1}}$. Additionally, we measure the metallicities of 16 member stars of Eri IV. We find a metallicity of $\mathrm{[Fe/H]}=-2.87^{+0.08}_{-0.07}$ and resolve a dispersion of $\sigma_{\mathrm{[Fe/H]}} = 0.20\pm0.09$. The mean metallicity is marginally lower than all other known ultra-faint dwarf galaxies, making it one of the most metal-poor galaxies discovered thus far. Eri IV also has a somewhat unusual right-skewed metallicity distribution. For Cen I, we find a velocity $v_{sys} = 44.9\pm0.8\:\mathrm{km\:s^{-1}}$ and velocity dispersion $\sigma_{v} = 4.2^{+0.6}_{-0.5} \:\mathrm{km\:s^{-1}}$. We measure the metallicities of 27 member stars of Cen I, and find a mean metallicity $\mathrm{[Fe/H]} = -2.57\pm0.08$ and metallicity dispersion $\sigma_{\mathrm{[Fe/H]}} = 0.38^{+0.07}_{-0.05}$. We calculate the systemic proper motion, orbit, and the astrophysical J-factor for each system, the latter of which indicates that Eri IV is a good target for indirect dark matter detection. We also find no strong evidence for tidal stripping of Cen I or Eri IV. Overall, our measurements confirm that Eri IV and Cen I are dark matter-dominated galaxies with properties largely consistent with other known ultra-faint dwarf galaxies. The low metallicity, right-skewed metallicity distribution, and high J-factor make Eri IV an especially interesting candidate for further followup.Comment: 25 pages, 11 figures, submitted to AAS journal

Status of the LEP2 Spectrometer Project

The LEP spectrometer has been conceived to provide a determination of the beam energy with a relative accuracy of 10-4 in the LEP2 physics region where insufficient polarisation levels prevent the application of the resonant depolarisation method. The setup consists of a steel bending magnet flanked by a triplet of Beam Position Monitors (BPM) at each side providing a measurement of changes in the bending angle when the beams are accelerated to physics energies. The goal for a 100 ppm relative precision on the beam energy involves a ± 1 micron BPM resolution and the calibration of the dipole bending strength to a 30 ppm accuracy. This paper reports on the results of the commissioning of the Spectrometer during the 1999 LEP Run and on the experience acquired on the behaviour of the several sub-systems with circulating beams

SIRTA, a ground-based atmospheric observatory for cloud and aerosol research

Ground-based remote sensing observatories have a crucial role to play in providing data to improve our understanding of atmospheric processes, to test the performance of atmospheric models, and to develop new methods for future space-borne observations. Institut Pierre Simon Laplace, a French research institute in environmental sciences, created the Site Instrumental de Recherche par Télédétection Atmosphérique (SIRTA), an atmospheric observatory with these goals in mind. Today SIRTA, located 20km south of Paris, operates a suite a state-of-the-art active and passive remote sensing instruments dedicated to routine monitoring of cloud and aerosol properties, and key atmospheric parameters. Detailed description of the state of the atmospheric column is progressively archived and made accessible to the scientific community. This paper describes the SIRTA infrastructure and database, and provides an overview of the scientific research associated with the observatory. Researchers using SIRTA data conduct research on atmospheric processes involving complex interactions between clouds, aerosols and radiative and dynamic processes in the atmospheric column. Atmospheric modellers working with SIRTA observations develop new methods to test their models and innovative analyses to improve parametric representations of sub-grid processes that must be accounted for in the model. SIRTA provides the means to develop data interpretation tools for future active remote sensing missions in space (e.g. CloudSat and CALIPSO). SIRTA observation and research activities take place in networks of atmospheric observatories that allow scientists to access consistent data sets from diverse regions on the globe

Invasion and MMP expression profile in desmoid tumours

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour, which could stimulate tumour invasiveness, was investigated. Using collagen gel invasion assays, the presence of factors stimulating invasion in desmoid conditioned media (CM) could be established. Since matrix metalloproteinases (MMPs) have been implicated in the process of tumoral invasion, the expression levels of the MMP family members were evaluated. Quantitative reverse transcription-PCR was used to determine the expression levels of MMP1, MMP2, MMP3, MMP7, MMP11, MMP12, MMP13, MMP14 and the inhibitors TIMP1, TIMP2 and TIMP3. Besides overexpression of MMP7, a known TCF-dependent target gene, a striking upregulation of the expression levels of MMP1, MMP3, MMP11, MMP12 and MMP13 in desmoid tumours, compared to unaffected fibroblasts from the same patients, was found. Treating the CM of desmoids with a synthetic and a physiologic MMP inhibitor reduced the invasion-stimulating capacity of the desmoid CM by approximately 50%. These results suggest the involvement of soluble factors, released by the desmoid cells, in stimulating invasion and implicate the MMPs as facilitators of invasion