746 research outputs found
Zero-Point cooling and low heating of trapped 111Cd+ ions
We report on ground state laser cooling of single 111Cd+ ions confined in
radio-frequency (Paul) traps. Heating rates of trapped ion motion are measured
for two different trapping geometries and electrode materials, where no effort
was made to shield the electrodes from the atomic Cd source. The low measured
heating rates suggest that trapped 111Cd+ ions may be well-suited for
experiments involving quantum control of atomic motion, including applications
in quantum information science.Comment: 4 pages, 6 figures, Submitted to PR
Entanglement of Trapped-Ion Clock States
A M{\o}lmer-S{\o}rensen entangling gate is realized for pairs of trapped
Cd ions using magnetic-field insensitive "clock" states and an
implementation offering reduced sensitivity to optical phase drifts. The gate
is used to generate the complete set of four entangled states, which are
reconstructed and evaluated with quantum-state tomography. An average
target-state fidelity of 0.79 is achieved, limited by available laser power and
technical noise. The tomographic reconstruction of entangled states
demonstrates universal quantum control of two ion-qubits, which through
multiplexing can provide a route to scalable architectures for trapped-ion
quantum computing.Comment: 6 pages, 5 figure
Quantifying Cognitive Reserve in Older Adults by Decomposing Episodic Memory Variance: Replication and Extension
The theory of cognitive reserve attempts to explain why some individuals are more resilient to age-related brain pathology. Efforts to explore reserve have been hindered by measurement difficulties. Reed et al. (2010) proposed quantifying reserve as residual variance in episodic memory performance that remains after accounting for demographic factors and brain pathology (whole brain, hippocampal, and white matter hyperintensity volumes). This residual variance represents the discrepancy between an individual's predicted and actual memory performance. The goals of the present study were to extend these methods to a larger, community-based sample and to investigate whether the residual reserve variable is explained by age, predicts longitudinal changes in language, and predicts dementia conversion independent of age. Results support this operational measure of reserve. The residual reserve variable was associated with higher reading ability, lower likelihood of meeting criteria for mild cognitive impairment, lower odds of dementia conversion in dependent of age, and less decline in language abilities over 3 years. Finally, the residual reserve variable moderated the negative impact of memory variance explained by brain pathology on language decline. This method has the potential to facilitate research on the mechanisms of cognitive reserve and the efficacy of interventions designed to impart reserve
Happiness and life satisfaction in Rwanda
This study investigated predictors of happiness and life satisfaction in Rwanda. Data from the World Values Survey and gathered from 3 030 Rwandese (age ranging 16 to 90 years, mean age = 34.2, SD = 12.7; females = 50.5%) were pooled for the analysis. For the comparison, international World Values Survey data were utilised. A fixed effects multilevel regression model was used to predict happiness and life satisfaction from gender, health, socio-economic, and some subjective measures. Males had greater self-rated happiness and life satisfaction scores than females. State of health and sense of freedom of choice predicted both happiness and life satisfaction. Valuing of friends, weekly religious attendance, and national pride positively predicted happiness, whereas householdâs financial satisfaction, full-time employment, high-income group, being a student, and sense of trust predicted life satisfaction. This study suggests that health status, householdâs financial satisfaction and emancipative values could maximise subjective well-being in Rwanda
Genome-wide scan in Hispanics highlights candidate loci for brain white matter hyperintensities
Objective: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population.
Methods: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington HeightsâInwood Columbia Aging Project. Multiple linear modeling with PLINK was performed to examine the additive genetic effects on ln(WMHV) after controlling for age, sex, total intracranial volume, and principal components of ancestry. Gene-based tests of association were performed using VEGAS. Replication was performed in independent samples of Europeans, African Americans, and Asians.
Results: From the SNP analysis, a total of 17 independent SNPs in 7 genes had suggestive evidence of association with WMHV in Hispanics (p < 1 Ă 10â5) and 5 genes from the gene-based analysis with p < 1 Ă 10â3. One SNP (rs9957475 in GATA6) and 1 gene (UBE2C) demonstrated evidence of association (p < 0.05) in the African American sample. Four SNPs with p < 1 Ă 10â5 were shown to affect binding of SPI1 using RegulomeDB.
Conclusions: This GWAS of 2 community-based Hispanic cohorts revealed several novel WMH-associated genetic variants. Further replication is needed in independent Hispanic samples to validate these suggestive associations, and fine mapping is needed to pinpoint causal variants
Efficient Photoionization-Loading of Trapped Cadmium Ions with Ultrafast Pulses
Atomic cadmium ions are loaded into radiofrequency ion traps by
photoionization of atoms in a cadmium vapor with ultrafast laser pulses. The
photoionization is driven through an intermediate atomic resonance with a
frequency-quadrupled mode-locked Ti:Sapphire laser that produces pulses of
either 100 fsec or 1 psec duration at a central wavelength of 229 nm. The large
bandwidth of the pulses photoionizes all velocity classes of the Cd vapor,
resulting in high loading efficiencies compared to previous ion trap loading
techniques. Measured loading rates are compared with a simple theoretical
model, and we conclude that this technique can potentially ionize every atom
traversing the laser beam within the trapping volume. This may allow the
operation of ion traps with lower levels of background pressures and less trap
electrode surface contamination. The technique and laser system reported here
should be applicable to loading most laser-cooled ion species.Comment: 11 pages, 12 figure
Precautionary Regulation in Europe and the United States: A Quantitative Comparison
Much attention has been addressed to the question of whether Europe or the United States adopts a more precautionary stance to the regulation of potential environmental, health, and safety risks. Some commentators suggest that Europe is more risk-averse and precautionary, whereas the US is seen as more risk-taking and optimistic about the prospects for new technology. Others suggest that the US is more precautionary because its regulatory process is more legalistic and adversarial, while Europe is more lax and corporatist in its regulations. The flip-flop hypothesis claims that the US was more precautionary than Europe in the 1970s and early 1980s, and that Europe has become more precautionary since then. We examine the levels and trends in regulation of environmental, health, and safety risks since 1970. Unlike previous research, which has studied only a small set of prominent cases selected non-randomly, we develop a comprehensive list of almost 3,000 risks and code the relative stringency of regulation in Europe and the US for each of 100 risks randomly selected from that list for each year from 1970 through 2004. Our results suggest that: (a) averaging over risks, there is no significant difference in relative precaution over the period, (b) weakly consistent with the flip-flop hypothesis, there is some evidence of a modest shift toward greater relative precaution of European regulation since about 1990, although (c) there is a diversity of trends across risks, of which the most common is no change in relative precaution (including cases where Europe and the US are equally precautionary and where Europe or the US has been consistently more precautionary). The overall finding is of a mixed and diverse pattern of relative transatlantic precaution over the period
Overcoming the novelty effect in online gamified learning systems: an empirical evaluation of student engagement and performance
Learners in the Higher Education context who engage with computer-based gamified learning systems often experience the novelty effect: a pattern of high activity during the gamified systemâs introduction followed by a drop in activity a few weeks later, once its novelty has worn off. We applied a two-tiered motivational, online gamified learning system over two years to a total number of 333 students. In a mixed methods research design, we used three-yearsâ worth of longitudinal data (333 students for the treatment group and 175 in the control group) to assess studentsâ engagement and performance in that period. Quantitative results established that students engaged and performed better in the gamified condition vis-aÌ-vis the non- gamified. Furthermore, students exhibited higher levels of engagement in the second year compared to the first year of the gamified condition. Our qualitative data suggests that students in the second year of the gamified delivery exhibited sustained engagement, overcoming the novelty effect. Thus, our main contribution is in suggesting ways of making the engagement meaningful and useful for the students thus sustaining their engagement with computer-based gamified learning systems and overcoming the novelty effect
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A pilot dose-response study of the acute effects of haskap berry extract (Lonicera caerulea L.) on cognition, mood and blood pressure in older adults
Purpose
Haskap (Lonicera caerulea L. or blue honeysuckle) is a plant native to the low-lying wet areas and mountains of Siberia and northeastern Asia, but is now cultivated in Canada. The dark blue berries are rich in anthocyanins, particularly cyanidin-3-O-glucoside. Previously, anthocyanin-rich fruits have been observed to benefit cognitive performance during the immediate postprandial period following a single acute dose. However, no study has currently examined the potential for haskap berries to influence cognitive performance. Here, we investigate the acute cognitive benefits of an anthocyanin-rich haskap berry extract.
Methods
A double-blind, counterbalanced, crossover intervention study compared the acute effects of three separate haskap berry extract doses, containing 100mg, 200mg, and 400mg anthocyanins, with a sugar-matched placebo. Participants were an opportunity sample of 20 older adults, aged 62-81 years. Measures of cognition, mood, and blood pressure were recorded at baseline and 1.5 hours postprandially.
Results
Compared to placebo, the 400mg dose elicited significantly lower diastolic blood pressure and heart rate. Both 200mg and 400mg doses elicited significantly higher word recall, with the 400mg dose also significantly improving word recognition scores, on an episodic memory task. However, mood, working memory and executive function task results were more equivocal.
Conclusions
The findings provide evidence for improvements in episodic memory and blood pressure following acute supplementation with haskap berry extract, with higher doses appearing most effective. The cognitive findings concur with previous literature that suggests episodic memory effects, and not executive function effects, are most prevalent in older adults following anthocyanin-rich berry supplementation. The blood pressure outcome is consistent with a vasodilatory mechanism of action
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