Sexual Differentiation of Circadian Clock Function in the Adrenal Gland

Sex differences in glucocorticoid production are associated with increased responsiveness of the adrenal gland in females. However, the adrenal-intrinsic mechanisms that establish sexual dimorphic function remain ill defined. Glucocorticoid production is gated at the molecular level by the circadian clock, which may contribute to sexual dimorphic adrenal function. Here we examine sex differences in the adrenal gland using an optical reporter of circadian clock function. Adrenal glands were cultured from male and female Period2::Luciferase (PER2::LUC) mice to assess clock function in vitro in real time. We confirm that there is a pronounced sex difference in the intrinsic capacity to sustain PER2::LUC rhythms in vitro, with higher amplitude rhythms in adrenal glands collected from males than from females. Changes in adrenal PER2::LUC rhythms over the reproductive life span implicate T as an important factor in driving sex differences in adrenal clock function. By directly manipulating hormone levels in adult mice in vivo, we demonstrate that T increases the amplitude of PER2::LUC rhythms in adrenal glands of both male and female mice. In contrast, we find little evidence that ovarian hormones modify adrenal clock function. Lastly, we find that T in vitro can increase the amplitude of PER2::LUC rhythms in male adrenals but not female adrenals, which suggests the existence of sex differences in the mechanisms of T action in vivo. Collectively these results reveal that activational effects of T alter circadian timekeeping in the adrenal gland, which may have implications for sex differences in stress reactivity and stress-related disorders

Dissolution of iron-chromium carbides during white layer formation induced by hard turning of AISI 52100 steel

The (Fe, Cr)3C carbide morphology in the surface region of hard turned bainitic AISI 52100 steel was investigated using both experimental techniques and simulations, where microstructural analysis was correlated with analytical studies of the carbide dissolution kinetics using DICTRA1. The experimental results showed that for both predominantly thermally and mechanically induced white layers no significant carbide dissolution took place down to a depth of 20 μm below the machined surfaces. This was confirmed by the analytical results from DICTRA, which showed that no significant carbide dissolution should take place during hard turning given the short contact times. Within the hard turned surfaces up to ∼12% of the carbides were elongated, indicating plastic deformation of the carbides during machining

Distorted Copulas: Constructions and Tail Dependence

Given a copula C, we examine under which conditions on an order isomorphism ψ of [0, 1] the distortion C ψ: [0, 1]2 → [0, 1], C ψ(x, y) = ψ{C[ψ−1(x), ψ−1(y)]} is again a copula. In particular, when the copula C is totally positive of order 2, we give a sufficient condition on ψ that ensures that any distortion of C by means of ψ is again a copula. The presented results allow us to introduce in a more flexible way families of copulas exhibiting different behavior in the tails

Runoff treatment with aspen wood

Runoff from roadways and urban areas is often contaminated with heavy metals such as zinc and copper. The use of aspen wood (Populus tremula) was investigated as a potential sorbentfor these metal contaminated runoff waters. The objective was to design an alternative runoff treatment technology based on a renewable resource, i.e. wood. Laboratory isotherms and column experiments were conducted in order to investigate the sorption and desorption of dissolved copper and zinc to and from aspen wood fibers. Sorption ofCu(II) and Zn(II) followed non-linear Freundlich isotherms. The aspen wood-water partition coefficient values revealed that Cu(II) had a greater tendency to sorb to the aspen wood than Zn(II). The column experiments indicated that, at least initially, both metals were being rapidly sorbed. During later stages of the sorption experiments, slower, but steady transport of the metal ions into the wood fibers appeared to be the dominating removal mechanism. Desorption of copper with E-pure water was faster than zinc, but the total amount of metal mass released from the wood was small in both cases, i.e., only 2% to 4% of the amount sorbed. Although initial dissolved metal removal data from an ongoing field test is inconclusive, it was shown that a proto-type wood filter and a viable runoff treatment technology can be build around wood-based filte

An Overview of Medicaid Managed Care Litigation

This Issue Brief is intended as one of several in the Managed Behavioral Health Care Issue Brief Series that deals with managed behavioral health care from a purely legal point of view. Since the enactment of Medicaid in 1965, states have had the option of offering beneficiaries enrollment in managed care arrangements. With the advent of mandatory managed care reaching millions of beneficiaries (including a growing proportion of disabled recipients), the amount and scope of litigation involving Medicaid managed care plans can be expected to grow. A review of the current litigation regarding Medicaid managed care reveals two basic types of lawsuits: (1) those that challenge the practices of managed care companies under various federal and state laws that safeguard consumer rights, protect health care quality, and prohibit discrimination; and (2) suits that assert claims arising directly under the Medicaid statute and implementing regulations, as well as claims related to Constitutional safeguards that undergird the program

Identifying stellar streams in the 1st RAVE public data release

We searched for and detected stellar streams or moving groups in the solar neighbourhood, using the data provided by the 1st RAVE public data release. This analysis is based on distances to RAVE stars estimated from a color-magnitude relation that was calibrated on Hipparcos stars. Our final sample consists of 7015 stars selected to be within 500 pc of the Sun and to have distance errors better than 25%. Together with radial velocities from RAVE and proper motions from various data bases, there are estimates for all 6 phase-space coordinates of the stars in the sample. We characterize the orbits of these stars through suitable proxies for their angular momentum and eccentricity, and compare the observed distribution to the expectations from a smooth distribution. On this basis we identify at least four "phase space overdensities" of stars on very similar orbits in the Solar neighbourhood. We estimate the statistical significance of these overdensities by Monte Carlo simulations. Three of them have been identified previously: the Sirius and Hercules moving group and a stream found independently in 2006 by Arifyanto and Fuchs and Helmi et al. In addition, we have found a new stream candidate on a quite radial orbit, suggesting an origin external to the Milky Way's disk. Also, there is evidence for the Arcturus stream and the Hyades-Pleiades moving group in the sample. This analysis, using only a minute fraction of the final RAVE data set, shows the power of this experiment to probe the phase-space substructure of stars around the Sun.Comment: accepted for publication in Ap

Preassociative aggregation functions

The classical property of associativity is very often considered in aggregation function theory and fuzzy logic. In this paper we provide axiomatizations of various classes of preassociative functions, where preassociativity is a generalization of associativity recently introduced by the authors. These axiomatizations are based on existing characterizations of some noteworthy classes of associative operations, such as the class of Acz\'elian semigroups and the class of t-norms.Comment: arXiv admin note: text overlap with arXiv:1309.730