11,404 research outputs found
Creation of the selection list for the Experiment Scheduling Program (ESP)
The efforts to develop a procedure to construct selection groups to augment the Experiment Scheduling Program (ESP) are summarized. Included is a User's Guide and a sample scenario to guide in the use of the software system that implements the developed procedures
Entropy and Entanglement in Quantum Ground States
We consider the relationship between correlations and entanglement in gapped
quantum systems, with application to matrix product state representations. We
prove that there exist gapped one-dimensional local Hamiltonians such that the
entropy is exponentially large in the correlation length, and we present strong
evidence supporting a conjecture that there exist such systems with arbitrarily
large entropy. However, we then show that, under an assumption on the density
of states which is believed to be satisfied by many physical systems such as
the fractional quantum Hall effect, that an efficient matrix product state
representation of the ground state exists in any dimension. Finally, we comment
on the implications for numerical simulation.Comment: 7 pages, no figure
Memory B cells and CD8âș lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques.
This study sought to define the role of memory lymphocytes in the protection from homologous influenza A virus re-challenge in rhesus macaques. Depleting monoclonal antibodies (mAb) were administered to the animals prior to their second experimental inoculation with a human seasonal influenza A virus strain. Treatment with either anti-CD8α or anti-CD20 mAbs prior to re-challenge had minimal effect on influenza A virus replication. Thus, in non-human primates with pre-existing anti-influenza A antibodies, memory B cells and CD8αâș T cells do not contribute to the control of virus replication after re-challenge with a homologous strain of influenza A virus
Information capacity of genetic regulatory elements
Changes in a cell's external or internal conditions are usually reflected in
the concentrations of the relevant transcription factors. These proteins in
turn modulate the expression levels of the genes under their control and
sometimes need to perform non-trivial computations that integrate several
inputs and affect multiple genes. At the same time, the activities of the
regulated genes would fluctuate even if the inputs were held fixed, as a
consequence of the intrinsic noise in the system, and such noise must
fundamentally limit the reliability of any genetic computation. Here we use
information theory to formalize the notion of information transmission in
simple genetic regulatory elements in the presence of physically realistic
noise sources. The dependence of this "channel capacity" on noise parameters,
cooperativity and cost of making signaling molecules is explored
systematically. We find that, at least in principle, capacities higher than one
bit should be achievable and that consequently genetic regulation is not
limited the use of binary, or "on-off", components.Comment: 17 pages, 9 figure
Student Days : March Two-Step
https://digitalcommons.library.umaine.edu/mmb-vp/2532/thumbnail.jp
Information Flow through a Chaotic Channel: Prediction and Postdiction at Finite Resolution
We reconsider the persistence of information under the dynamics of the
logistic map in order to discuss communication through a nonlinear channel
where the sender can set the initial state of the system with finite
resolution, and the recipient measures it with the same accuracy. We separate
out the contributions of global phase space shrinkage and local phase space
contraction and expansion to the uncertainty in predicting and postdicting the
state of the system. Thus, we determine how the amplification parameter, the
time lag, and the resolution influence the possibility for communication. A
novel representation for real numbers is introduced that allows for a
visualization of the flow of information between scales.Comment: 14 pages, 13 figure
Dynamics of the Fisher Information Metric
We present a method to generate probability distributions that correspond to
metrics obeying partial differential equations generated by extremizing a
functional , where is the
Fisher metric. We postulate that this functional of the dynamical variable
is stationary with respect to small variations of these
variables. Our approach enables a dynamical approach to Fisher information
metric. It allows to impose symmetries on a statistical system in a systematic
way. This work is mainly motivated by the entropy approach to nonmonotonic
reasoning.Comment: 11 page
Molecular Dynamics in Hydrogenâbonded Interactions: A Preliminary Experimentally Determined Harmonic Stretching Force Field for HCNâââHF
Observation of the 2Îœ1 overtone band in the hydrogenâbonded complex HCNâââHF permits evaluation of the anharmonicity constant X 1 1=â116.9(1) cmâ 1 and determination of the anharmonicity corrected fundamental frequency Ï1. This information, and available data from previous rovibrational analyses in the common and perdeuterated isotopic species of HCNâââHF, offer an opportunity for calculation of an approximate stretching harmonic force field. With the assumptions f 1 2=f 2 4=0.0, the remaining force constants (in mdyn/Ă
) are evaluated as: f 1 1=8.600(20), f 2 2=6.228(9), f 3 3=19.115(40), f 4 4=0.2413(39), f 1 3=0.000(13), f 1 4=0.0343(2), f 2 3=â0.211(6), f 3 4=0.000(2). These compare to f 1 1=9.658(2) in the HF monomer and f 1 1=6.244(3) and f 3 3=18.707(16) in the HCN monomer. These results provide the information necessary to quantitatively assess the applicability of the Cummings and Wood approximation in this hydrogenâbonded complex and also give an estimate of D e j , the equilibrium distortion constant in the harmonic limit. Comparisons of these experimentally determined parameters with the predictions of a b i n i t i o molecular orbital calculations at several levels of approximation are presented
Specific protein-protein binding in many-component mixtures of proteins
Proteins must bind to specific other proteins in vivo in order to function.
The proteins must bind only to one or a few other proteins of the of order a
thousand proteins typically present in vivo. Using a simple model of a protein,
specific binding in many component mixtures is studied. It is found to be a
demanding function in the sense that it demands that the binding sites of the
proteins be encoded by long sequences of bits, and the requirement for specific
binding then strongly constrains these sequences. This is quantified by the
capacity of proteins of a given size (sequence length), which is the maximum
number of specific-binding interactions possible in a mixture. This calculation
of the maximum number possible is in the same spirit as the work of Shannon and
others on the maximum rate of communication through noisy channels.Comment: 13 pages, 3 figures (changes for v2 mainly notational - to be more in
line with notation in information theory literature
- âŠ