Venom Proteins of the Parasitoid Wasp Nasonia vitripennis: Recent Discovery of an Untapped Pharmacopee

Adult females of Nasonia vitripennis inject a venomous mixture into its host flies prior to oviposition. Recently, the entire genome of this ectoparasitoid wasp was sequenced, enabling the identification of 79 venom proteins. The next challenge will be to unravel their specific functions, but based on homolog studies, some predictions already can be made. Parasitization has an enormous impact on hosts physiology of which five major effects are discussed in this review: the impact on immune responses, induction of developmental arrest, increases in lipid levels, apoptosis and nutrient releases. The value of deciphering this venom is also discussed

Axillary vein thrombosis induced by an increasingly popular oscillating dumbbell exercise device: a case report

A 53 year-old male presented with a one-day history of a swollen arm and dull, aching pain in the right upper extremity. The patient reported commencing exercising daily over the prior week with a modified, oscillating dumbbell; commonly referred to as a Shake Weight. Imaging revealed an occlusive thrombus in the right axillary, proximal brachial and basilic veins. The patient was treated with a 24-hour tPA infusion followed by mechanical thrombectomy, balloon angioplasty, and stent placement for a residual thrombus and stenosis. The patient was discharged the following day on warfarin and aspirin. This is the first report of effort-induced thrombosis of the upper extremity following the use of a modified, oscillating dumbbell. Due to the growing popularity of modified dumbbells and the possible risk for axillary vein thrombosis, consideration should be made to caution consumers of this potential complication.This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at [email protected]

Tissue-type plasminogen activator therapy versus primary coronary angioplasty: Impact on myocardial tissue perfusion and regional function 1 month after uncomplicated myocardial infarction

Objectives. This study sought to compare the impact of primary coronary angioplasty and thrombolytic therapy for acute myocardial infarction (AMI) on 1-month infarct size and microvascular perfusion. Background. The effect of the reperfusion strategies of primary coronary angioplasty and thrombolytic therapy on microvascular integrity still remains to be determined. Methods. Sixty two consecutive patients with a first AMI, undergoing intravenous tissue-type plasminogen activator (t-PA) therapy (32 patients, Group I) or primary angioplasty (30 patients, Group II), were studied. Only patients with 1-month Thrombolysis in Myocardial Infarction (TIMI) flow grade 2 or 3 were selected for the study, Patients in whom primary angioplasty was unsuccessful or those with clinical evidence of failed reperfusion were excluded. Microvascular perfusion was assessed at 1 month by intracoronary injection of sonicated microbubbles. Contrast score index (CSI) and wall motion score index (WMSI) were derived using qualitative methods. Results. At baseline there were no significant differences between groups for age, risk factors, time to hospital presentation, Killip class on admission, prevalence of multivessel disease or anterior infarct site, infarct area extension before reperfusion, peak creatine kinase levels and postinfarction treatment. Conversely, significant differences between groups were found at follow-up for percent residual infarct related-artery (IRA) stenosis (70 +/- 12 vs 36 +/- 14 [mean +/- SD], p = 0.0001), CSI (1.02 +/- 0.4 vs. 1.49 +/- 0.5, p = 0.0003) and WMSI (1.67 +/- 0.3 vs. 1.45 +/- 0.3, p = 0.015). In particular, in the subset of patients with TIMI grade 3 flow, a perfusion defect occurred in one or more segments subtended by the IRA in 72% of Group I versus 31% of Group II patients (p < 0.00001) and in 27% of Group I versus 8% of Group II segments (p < 0.00001), Conclusions. The present study shows, in a highly selected cohort with successful IRA recanalization, that primary angioplasty is more effective than thrombolysis in preserving microvascular flow and preventing extension of myocardial damage at 1-month after AMI. (C) 1998 by the American College of Cardiology

Sea TENTACLE: Track, Engage, & Neutralize Threats - Asymmetric & Conventional - in the Littoral Environment

Includes supplementary materialSea TENTACLE is a proposed afloat platform whose primary mission is to utilize the state-of-the-art technology of unmanned vehicles to monitor and neutralize all subsurface enemy threats in the littorals. This mission can be specified further as anti-submarine warfare, mine warfare and maritime surveillance. The design philosophy of Sea TENTACLE embodies the ideal of providing a multi-mission capable sea frame extending network-centric warfare into the littorals. The design goals of the TSSE team were first to develop a platform to deploy, recover, and maintain unmanned vehicle (e.g. UUVs, USVs, UAVs) and second to enableto ship to act as an afloat network operations center for distributed assets. Allowing all units to work together seamlessly to conduct focused missions in the littorals makes the Sea TENTACLE a creitical component within the network-centric environment. The versatility of its cargo hold and modular design allows Sea TENTACLE to be outfitted dynamically to complete a veriety of secondary missions including humanitarian aid, salvage and spacial operations support. Sea TENTACLE's combat management and operations system will employ the Enterprise architecture design enabling C4ISR capabilities that will meet emerging network centric warfare needs.US Navy (USN) authorsTunisian Navy authorTurkish Navy authorsApproved for public release; distribution is unlimited

Preridiniopsis Kevei SP. nov., A new freshwater dinoflagellate species (peridiniceae, dinophyta) from Hungary

This paper reports results from light and scanning electron microscopic study of a freshwater dinoflagellate considered as a new species for the science, Peridiniopsis keveisp. nov. It was found during the last ten years in different lake, rivers, canals in Hungary and some European countries. it frequently appeared as a water-bloom forming species. The theca morphology and and plate structure analysis of this dinoflagellate established its identity as a new species. P. kevei Grigorszky et Vasas is discussed in the paper in comparsion with related taxa, moreover data about its occurrence and ecology

Kinetic Studies on the Reaction of Chlorosulfonyl Isocyanate with Monofluoroalkenes: Experimental Evidence for Both Stepwise and Concerted Mechanisms and a Pre-equilibrium Complex on the Reaction Pathway

Chlorosulfonyl isocyanate (CSI) is reported to react with hydrocarbon alkenes by a stepwise dipolar pathway to give <i>N</i>-chlorosulfonyl-β-lactams that are readily reduced to β-lactams. Substitution of a vinyl hydrogen for a vinyl fluorine changes the dynamics for reaction with CSI so that a concerted pathway is favored. Rate constants were measured for reactions of CSI with monofluoroalkenes and some hydrocarbon alkenes. Activation parameters for two hydrocarbon alkenes and two monofluoroalkenes support this change in mechanism. A plot generated from the natural log of rate constants vs ionization potentials (IP) indicates that fluoroalkenes with IP values >8.9 eV react by a concerted process. Electron-rich monofluoroalkenes with IP values <8.5 eV were found to react by a single-electron transfer (SET) pathway. Hydrocarbon alkenes were also found to react by this dipolar stepwise SET intermediate rather than the previously accepted stepwise dipolar pathway. Data support a pre-equilibrium complex on the reaction pathway just before the rate-determining step of the concerted pathway and a SET intermediate for the stepwise reactions. When the reactions are carried out at lower temperatures, the equilibrium shifts toward the complex or SET intermediate enhancing the synthetic utility of these reactions. Kinetic data also support formation of a planar transition state rather than the orthogonal geometry as reported for ketene [2 + 2] cycloadditions