The use of PH 203 (Panthesine hydergine) in thrombo-embolic diseases in obstetrics and gynaecology

No Abstrac

Dip-coating of suspensions

Withdrawing a plate from a suspension leads to the entrainment of a coating layer of fluid and particles on the solid surface. In this article, we study the Landau-Levich problem in the case of a suspension of non-Brownian particles at moderate volume fraction $10\% < \phi < 41\%$. We observe different regimes depending on the withdrawal velocity $U$, the volume fraction of the suspension $\phi$, and the diameter of the particles $2\,a$. Our results exhibit three coating regimes. (i) At small enough capillary number $Ca$, no particles are entrained, and only a liquid film coats the plate. (ii) At large capillary number, we observe that the thickness of the entrained film of suspension is captured by the Landau-Levich law using the effective viscosity of the suspension $\eta(\phi)$. (iii) At intermediate capillary numbers, the situation becomes more complicated with a heterogeneous coating on the substrate. We rationalize our experimental findings by providing the domain of existence of these three regimes as a function of the fluid and particles properties

Vertebrate Air Breathing Arose In Fresh Waters And Not In The Oceans

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137418/1/evo00662.pd

Paleo- stress and strain rates in an intra-arc strike-slip fault, Sierra Nevada, California

Structures and microstructures of the Proto-Kern Canyon fault (PKCF), a 130-km-long dextral strike-slip shear zone of the southern Sierra Nevada batholith, provide constraints on displacement, flow stress, and strain rate during arc formation. Shear strain analyses of S-C mylonites indicate ~5 km of ductile dextral slip along the PKCF. But field mapping and measurements of individual plutons and metamorphic pendants show these bodies have much more elongated aspect ratios, of up to 1:17, within the shear zone than outside of it. This suggests significantly higher strain and dextral slip of up to 15 km along the highest-strain zone of the PKCF. Petrographic observations of high-strain igneous rocks near Lake Isabella indicate that deformation started at temperatures of 400-450° C and continued through cooling to ~300° C. Based on ^(40)Ar/^(39)Ar dating of hornblende, mica, and K-feldspar, early cooling (~20° C/m.y.) from 88-70 Ma was followed by very slow cooling (~1° C/m.y.). These data, combined with cross-cutting relationships, suggest that dextral ductile shear was active from 90-86 Ma. Grain sizes of dynamically recrystallized pure quartz mylonites in this part of the shear zone were used to estimate flow stresses of 20-40 MPa. Applying mylonitization temperature estimates of 400-350° C and lithostatic pressures of 350- 400 MPa (from Al-in-hbl barometry) yields paleo-strain rates along the PKCF of 10^(-13)-10^(-15) /s. Additional quartzite piezometry, as well as calcite piezometry on marble mylonites, should provide further constraints on stress and strain rates along the length and depth exposures of this intrabatholithic shear zone

The association between neuroticism and self-reported common somatic symptoms in a population cohort

OBJECTIVE: To test the hypotheses that (1) neuroticism is associated with self-reported somatic symptoms; (2) this association is especially found with regard to psychosomatic symptoms; and (3) it is not solemnly explained by somatic reflections of psychological distress. METHODS: We studied the cross-sectional association between neuroticism (as measured by EPQ-RSS-N), psychological distress (as measured by GHQ-12 sum score), and the occurrence of 22 common somatic symptoms by linear and logistic regression analyses in a population cohort of 6894 participants. RESULTS: Neuroticism is more strongly associated with the total number of somatic symptoms reported (beta=.32) than GHQ-12 sum score (beta=.15) and well-established risk markers such as gender (beta=.11) and age (beta=.04). Neuroticism was associated with all symptoms in individual logistic regressions controlled for age, gender, and psychological distress. Neuroticism is significantly more strongly related to psychosomatic symptoms (beta=.36) than to infectious/allergic symptoms (beta=.28). CONCLUSION: In a large, population-based cohort, we confirmed that neuroticism is associated with self-reported somatic symptoms. The associations were not attributable to somatic reflections of psychological distress associated with neuroticism and were relatively strong with respect to psychosomatic symptoms. Future studies should include both objective and subjective measures of health to study the mechanisms that connect neuroticism and ill health