9,545 research outputs found

    Applications of FEM and BEM in two-dimensional fracture mechanics problems

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    A comparison of the finite element method (FEM) and boundary element method (BEM) for the solution of two-dimensional plane strain problems in fracture mechanics is presented in this paper. Stress intensity factors (SIF's) were calculated using both methods for elastic plates with either a single-edge crack or an inclined-edge crack. In particular, two currently available programs, ANSYS for finite element analysis and BEASY for boundary element analysis, were used

    Radiation counting technique allows density measurement of metals in high-pressure/ high-temperature environment

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    Radioactive tracers induced by neutron irradiation provide a gamma ray flux proportional to the density of a metal, allowing density measurement of these metals in extreme high-temperature and high-pressure environments. This concept is applicable to most metals, as well as other substances

    Energy management study for lunar oxygen production

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    Energy management opportunities in the process of hydrogen reduction of ilmenite for lunar oxygen production are being investigated. An optimal energy system to supply the power requirements for the process will be determined

    Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.

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    To restrict infection by Legionella pneumophila, mouse macrophages require Naip5, a member of the nucleotide-binding oligomerization domain leucine-rich repeat family of pattern recognition receptors, which detect cytoplasmic microbial products. We report that mouse macrophages restricted L. pneumophila replication and initiated a proinflammatory program of cell death when flagellin contaminated their cytosol. Nuclear condensation, membrane permeability, and interleukin-1beta secretion were triggered by type IV secretion-competent bacteria that encode flagellin. The macrophage response to L. pneumophila was independent of Toll-like receptor signaling but correlated with Naip5 function and required caspase 1 activity. The L. pneumophila type IV secretion system provided only pore-forming activity because listeriolysin O of Listeria monocytogenes could substitute for its contribution. Flagellin monomers appeared to trigger the macrophage response from perforated phagosomes: once heated to disassemble filaments, flagellin triggered cell death but native flagellar preparations did not. Flagellin made L. pneumophila vulnerable to innate immune mechanisms because Naip5+ macrophages restricted the growth of virulent microbes, but flagellin mutants replicated freely. Likewise, after intratracheal inoculation of Naip5+ mice, the yield of L. pneumophila in the lungs declined, whereas the burden of flagellin mutants increased. Accordingly, macrophages respond to cytosolic flagellin by a mechanism that requires Naip5 and caspase 1 to restrict bacterial replication and release proinflammatory cytokines that control L. pneumophila infection

    Factor demand linkages, technology shocks, and the business cycle

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    This paper argues that factor demand linkages can be important for the transmission of both sectoral and aggregate shocks. We show this using a panel of highly disaggregated manufacturing sectors together with sectoral structural VARs. When sectoral interactions are explicitly accounted for, a contemporaneous technology shock to all manufacturing sectors implies a positive response in both output and hours at the aggregate level. Otherwise there is a negative correlation, as in much of the existing literature. Furthermore, we find that technology shocks are important drivers of the business cycle

    Circular 64

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    Treatment of Alaska-produced food products by ionizing radiation may benefit the seafood and agricultural industries and the Alaskan consumer. A feasibility study to evaluate the potential social and economic benefits and risks as well as the costs of using the process in Alaska on Alaskan products is being coordinated by the Institute of Northern Engineering. A research and development project to determine effects on the quality o f Alaskan products could be the next phase in the introduction o f a new food-preservation technique to Alaska

    Tests of the Gravitational Inverse-Square Law below the Dark-Energy Length Scale

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    We conducted three torsion-balance experiments to test the gravitational inverse-square law at separations between 9.53 mm and 55 micrometers, probing distances less than the dark-energy length scale λd=c/ρd485μ\lambda_{\rm d}=\sqrt[4]{\hbar c/\rho_{\rm d}}\approx 85 \mum. We find with 95% confidence that the inverse-square law holds (α1|\alpha| \leq 1) down to a length scale λ=56μ\lambda = 56 \mum and that an extra dimension must have a size R44μR \leq 44 \mum.Comment: 4 pages, 6 figure
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