2,532 research outputs found
Relative biological effectiveness of fast neutrons compared with X-rays: Prenatal mortality in the mouse
The effects of fission neutrons and of X-rays on the mouse zygote are discussed. Seven-week-old virgin mice were allowed a 12-hour mating opportunity beginning at 7:00 P.M. Between 1:30 and 4:00 P.M., except where indicated otherwise, the females which had mated (vaginal plug) during the night were either irradiated or sham-irradiated. At the time of irradiation the zygotes were in a pronuclear stage. Sixteen days later the mice were killed and the uteri dissected. The number of dead embryos, live embryos, and gross anomalies were determined. Dead embryos were classified as to stage of development
Nuclear and Particle Physics applications of the Bohm Picture of Quantum Mechanics
Approximation methods for calculating individual particle/ field motions in
spacetime at the quantum level of accuracy (a key feature of the Bohm Picture
of Quantum Mechanics (BP)), are studied. Modern textbook presentations of
Quantum Theory are used throughout, but only to provide the necessary, already
existing, tested formalisms and calculational techniques. New coherent
insights, reinterpretations of old solutions and results, and new (in principle
testable) quantitative and qualitative predictions, can be obtained on the
basis of the BP that complete the standard type of postdictions and
predictions.Comment: 41 page
Confining potential in a color dielectric medium with parallel domain walls
We study quark confinement in a system of two parallel domain walls
interpolating different color dielectric media. We use the phenomenological
approach in which the confinement of quarks appears considering the QCD vacuum
as a color dielectric medium. We explore this phenomenon in QCD_2, where the
confinement of the color flux between the domain walls manifests, in a scenario
where two 0-branes (representing external quark and antiquark) are connected by
a QCD string. We obtain solutions of the equations of motion via first-order
differential equations. We find a new color confining potential that increases
monotonically with the distance between the domain walls.Comment: RevTex4, 5 pages, 1 figure; version to appear in Int. J. Mod. Phys.
Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair
Nucleotide excision repair (NER) in yeast is effected by the concerted action of a large complex of proteins. Recently, we identified a stable subcomplex containing the yeast Rad7 and Rad16 proteins. Here, we report the identification of autonomously replicating sequence binding factor 1 (ABF1) as a component of the Rad7/Rad16 NER subcomplex. Yeast ABF1 protein is encoded by an essential gene required for DNA replication, transcriptional regulation, and gene silencing. We show that ABF1 plays a direct role in NER in vitro. Additionally, consistent with a role of ABF1 protein in NER in vivo, we show that certain temperature-sensitive abf1 mutant strains that are defective in DNA replication are specifically defective in the removal of photoproducts by NER and are sensitive to killing by ultraviolet (UV) radiation. These studies define a novel and unexpected role for ABF1 protein during NER in yeast
Vortex solutions of a Maxwell-Chern-Simons field coupled to four-fermion theory
We find the static vortex solutions of the model of Maxwell-Chern-Simons
gauge field coupled to a (2+1)-dimensional four-fermion theory. Especially, we
introduce two matter currents coupled to the gauge field minimally: the
electromagnetic current and a topological current associated with the
electromagnetic current. Unlike other Chern-Simons solitons the N-soliton
solution of this theory has binding energy and the stability of the solutions
is maintained by the charge conservation laws.Comment: 7 pages, harvmac, To be published in Phys. Rev. D5
The Importance of DNA Repair in Tumor Suppression
The transition from a normal to cancerous cell requires a number of highly
specific mutations that affect cell cycle regulation, apoptosis,
differentiation, and many other cell functions. One hallmark of cancerous
genomes is genomic instability, with mutation rates far greater than those of
normal cells. In microsatellite instability (MIN tumors), these are often
caused by damage to mismatch repair genes, allowing further mutation of the
genome and tumor progression. These mutation rates may lie near the error
catastrophe found in the quasispecies model of adaptive RNA genomes, suggesting
that further increasing mutation rates will destroy cancerous genomes. However,
recent results have demonstrated that DNA genomes exhibit an error threshold at
mutation rates far lower than their conservative counterparts. Furthermore,
while the maximum viable mutation rate in conservative systems increases
indefinitely with increasing master sequence fitness, the semiconservative
threshold plateaus at a relatively low value. This implies a paradox, wherein
inaccessible mutation rates are found in viable tumor cells. In this paper, we
address this paradox, demonstrating an isomorphism between the conservatively
replicating (RNA) quasispecies model and the semiconservative (DNA) model with
post-methylation DNA repair mechanisms impaired. Thus, as DNA repair becomes
inactivated, the maximum viable mutation rate increases smoothly to that of a
conservatively replicating system on a transformed landscape, with an upper
bound that is dependent on replication rates. We postulate that inactivation of
post-methylation repair mechanisms are fundamental to the progression of a
tumor cell and hence these mechanisms act as a method for prevention and
destruction of cancerous genomes.Comment: 7 pages, 5 figures; Approximation replaced with exact calculation;
Minor error corrected; Minor changes to model syste
Weyl group multiple Dirichlet series constructed from quadratic characters
We construct multiple Dirichlet series in several complex variables whose
coefficients involve quadratic residue symbols. The series are shown to have an
analytic continuation and satisfy a certain group of functional equations.
These are the first examples of an infinite collection of unstable Weyl group
multiple Dirichlet series in greater than two variables.Comment: incorporated referee's comment
Bogomol'nyi Equations of Maxwell-Chern-Simons vortices from a generalized Abelian Higgs Model
We consider a generalization of the abelian Higgs model with a Chern-Simons
term by modifying two terms of the usual Lagrangian. We multiply a dielectric
function with the Maxwell kinetic energy term and incorporate nonminimal
interaction by considering generalized covariant derivative. We show that for a
particular choice of the dielectric function this model admits both topological
as well as nontopological charged vortices satisfying Bogomol'nyi bound for
which the magnetic flux, charge and angular momentum are not quantized. However
the energy for the topolgical vortices is quantized and in each sector these
topological vortex solutions are infinitely degenerate. In the nonrelativistic
limit, this model admits static self-dual soliton solutions with nonzero finite
energy configuration. For the whole class of dielectric function for which the
nontopological vortices exists in the relativistic theory, the charge density
satisfies the same Liouville equation in the nonrelativistic limit.Comment: 30 pages(4 figures not included), RevTeX, IP/BBSR/93-6
The random lattice as a regularization scheme
A semi-analytic method to compute the first coefficients of the
renormalization group functions on a random lattice is introduced. It is used
to show that the two-dimensional non-linear -model regularized
on a random lattice has the correct continuum limit. A degree of
``randomness'' in the lattice is introduced and an estimate of the ratio
for two rather opposite values of
in the -model is also given. This ratio turns out to depend on
.Comment: PostScript file. 22 pages. Revised and enlarged versio
- …