741 research outputs found

    Referencing and borrowing from other systems: the Hong Kong education reforms

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    BACKGROUND: This paper analyses the role of, and approach to, policy referencing and borrowing in Hong Kong’s recent reforms that culminated in the creation of its New Academic Structure and the Hong Kong Diploma of Secondary Education. MAIN ARGUMENT: It argues that Hong Kong has gone further than most jurisdictions not just in responding to global influences on education reform, but in taking explicit steps to internationally benchmark its curriculum and assessment, and in involving the global community at multiple levels in the process of education policy planning and implementation. SOURCES OF EVIDENCE AND METHOD: The paper is based on the documentary analysis of policy documents in Hong Kong, and 23 interviews with key stakeholders in the policy network, including policy-makers, practitioners and community leaders. DISCUSSION AND CONCLUSIONS: While policy referencing and borrowing in the Hong Kong context can, in part, be traced to a colonial legacy, the Special Administrative Region of China demonstrates a collaborative approach to education reform involving local and international engagement that may be relevant to other systems. Its approach was informed by a measured use of policy referencing that involved ‘horizon scanning’ of other systems’ policies and practices; international benchmarking; and engaging international expertise to facilitate implementation

    PISA, policymaking and political pantomime: education policy referencing between England and Hong Kong

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    Since the mid-1980s, a number of East Asian societies have consistently performed well in international tests, and their education systems have emerged as models of ‘best practice’, including Hong Kong, which has been extensively referenced by politicians and their advisers in England. In parallel, local dissatisfaction with the education system in Hong Kong has prompted major education reforms. This mismatch between the perceptions of the Hong Kong education system of the two policy communities is explored using documentary analysis and interviews with policymakers and other key stakeholders. We analyse the ways in which features of Hong Kong’s education system are reconstructed and projected in policymaking in England and argue that the referencing to Hong Kong in England is akin to a form of political theatre, reminiscent of a pantomime, with stereotyped villains, heroes and fairy godmothers, narratives of good conquering evil, and comical set-pieces. We argue that these elements provide the means for both constructing and validating simple causal claims and their associated policy actions

    Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids.

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    To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldDic(9;20)(p13;q11) was first described as a nonrandom chromosome abnormality in B-cell precursor acute lymphoblastic leukaemia (BCP ALL) in the mid 1990s,1, 2 and 71 dic(9;20)-positive cases have since then been reported.3, 4, 5 Approximately 90% of these cases were children or adolescents, with dic(9;20) occurring in about 2% of childhood BCP ALL.6 The recent review by Forestier et al.5 describes that dic(9;20)-leukaemias are of B-cell precursor immunophenotype, never have a high hyperdiploid modal number, show a female predominance, and have a significant age incidence peak at 3 years. Most patients are allocated to non-standard risk treatment arms due to high WBC (median 24 109/l) and a relatively high frequency of CNS disease or other extra-medullary leukaemia (EML) at diagnosis. The prognostic implications of dic(9;20) are to a large extent unknown. A relatively large proportion of the relapses reported in the literature have been extra-medullary, and post-relapse treatment including block therapy has been successful in several patients, as illustrated by a p-EFS of 0.62 and a predicted overall survival of 0.82 at 5 years for the 24 Nordic cases.

    Multi-modality image simulation with the Virtual Imaging Platform: Illustration on cardiac echography and MRI

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    International audienceMedical image simulation is useful for biological modeling, image analysis, and designing new imaging devices but it is not widely available due to the complexity of simulators, the scarcity of object models, and the heaviness of the associated computations. This paper presents the Virtual Imaging Platform, an openly-accessible web platform for multi-modality image simulation. The integration of simulators and models is described and exemplified on simulated cardiac MRIs and ultrasonic images

    'Choosing shoes': a preliminary study into the challenges facing clinicians in assessing footwear for rheumatoid patients

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    Background: Footwear has been accepted as a therapeutic intervention for the foot affected by rheumatoid arthritis (RA). Evidence relating to the objective assessment of footwear in patients with RA is limited. The aims of this study were to identify current footwear styles, footwear characteristics, and factors that influence footwear choice experienced by patients with RA. Methods: Eighty patients with RA were recruited from rheumatology clinics during the summer months. Clinical characteristics, global function, and foot impairment and disability measures were recorded. Current footwear, footwear characteristics and the factors associated with choice of footwear were identified. Suitability of footwear was recorded using pre-determined criteria for assessing footwear type, based on a previous study of foot pain. Results: The patients had longstanding RA with moderate-to severe disability and impairment. The foot and ankle assessment demonstrated a low-arch profile with both forefoot and rearfoot structural deformities. Over 50% of shoes worn by patients were opentype footwear. More than 70% of patients’ footwear was defined as being poor. Poor footwear characteristics such as heel rigidity and sole hardness were observed. Patients reported comfort (17%) and fit (14%) as important factors in choosing their own footwear. Only five percent (5%) of patients wore therapeutic footwear. Conclusions: The majority of patients with RA wear footwear that has been previously described as poor. Future work needs to aim to define and justify the specific features of footwear that may be of benefit to foot health for people with RA

    Collisionless Shock Acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

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    We recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet [J.-R. Marqu\`es et al., Phys. Plasmas 28, 023103 (2021)]. In the continuation of this numerical work, we studied experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond-laser, in three cases: without tailoring, by tailoring only the entrance side of the ps-laser, or both sides of the gas jet. Without tailoring the acceleration is transverse to the laser axis, with a low-energy exponential spectrum, produced by Coulomb explosion. When the front side of the gas jet is tailored, a forward acceleration appears, that is significantly enhanced when both the front and back sides of the plasma are tailored. This forward acceleration produces higher energy protons, with a peaked spectrum, and is in good agreement with the mechanism of Collisionless Shock Acceleration (CSA). The spatio-temporal evolution of the plasma profile was characterized by optical shadowgraphy of a probe beam. The refraction and absorption of this beam was simulated by post-processing 3D hydrodynamic simulations of the plasma tailoring. Comparison with the experimental results allowed to estimate the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas jet. These parameters are in good agreement with those required for CSA

    Phylogenetic and molecular analysis of hydrogen-producing green algae

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    A select set of microalgae are reported to be able to catalyse photobiological H2 production from water. Based on the model organism Chlamydomonas reinhardtii, a method was developed for the screening of naturally occurring H2-producing microalgae. By purging algal cultures with N2 in the dark and subsequent illumination, it is possible to rapidly induce photobiological H2 evolution. Using NMR spectroscopy for metabolic profiling in C. reinhardtii, acetate, formate, and ethanol were found to be key compounds contributing to metabolic variance during the assay. This procedure can be used to test algal species existing as axenic or mixed cultures for their ability to produce H2. Using this system, five algal isolates capable of H2 production were identified in various aquatic systems. A phylogenetic tree was constructed using ribosomal sequence data of green unicellular algae to determine if there were taxonomic patterns of H2 production. H2-producing algal species were seen to be dispersed amongst most clades, indicating an H2-producing capacity preceded evolution of the phylum Chlorophyta

    Learning fuzzy rules to characterize objects of interest from remote sensing images

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    In this article a new method for learning concepts from examples of objects provided by experts for remote sensing images is presented. The goal of this method is to give the geographer expert a description of complex objects of interest extracted from very high resolution remote sensing images. The description of such objects needs to handle imprecision inherent to segmentation and very high resolution images. The first step of this approach is to classify objects composing all the examples. This classification allows the learning of a rule describing how the examples are composed regarding the segmentation. Finally, this rule is used to extract objects corresponding to the examples. Experiments on a remote sensing image of a urban landscape in Toulouse, France are presented to show the relevance of the method

    Fast segmentation for texture-based cartography of whole slide images

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    In recent years, new optical microscopes have been developed, providing very high spatial resolution images called Whole Slide Images (WSI). The fast and accurate display of such images for visual analysis by pathologists and the conventional automated analysis remain challenging, mainly due to the image size (sometimes billions of pixels) and the need to analyze certain image features at high resolution. To propose a decision support tool to help the pathologist interpret the information contained by the WSI, we present a new approach to establish an automatic cartography of WSI in reasonable time. The method is based on an original segmentation algorithm and on a supervised multiclass classification using a textural characterization of the regions computed by the segmentation. Application to breast cancer WSI shows promising results in terms of speed and quality

    Synthesizing Whole Slide Images

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    The increasing availability of digital whole slide images opens new perspectives for computer-assisted image analysis complementing modern histopathology, assuming we can implement reliable and efficient image analysis algorithms to extract the biologically relevant information. Both validation and supervised learning techniques typically rely on ground truths manually made by human experts. However, this task is difficult, subjective and usually not exhaustive. This is a well-known issue in the field of biomedical imaging, and a common solution is the use of artificial “phantoms”. Following this trend, we study the feasibility of synthesizing artificial histological images to create perfect ground truths. In this paper, we show that it is possible to generate a synthetic whole slide image with reasonable computing resources, and we propose a way to evaluate its quality
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