Carica Papaya’s Anti-Diabetic and Anti-Cancer Properties – A Review

The Carica papaya originates from the Caricaceae family, and various members of this family have been used as treatments for a range of ailments. The perennial plant C. papaya, which is currently found over the whole tropical region, is thought to have originated in the southern region of Mexico. To assess the biological activity of distinct C. papaya sections, several scientific studies have been carried out. Since ancient times, the papaya plant's many components have been employed for medicinal purposes. In this article, the process of extracting Carica papaya leaves as well as the anti-cancer and anti-diabetic properties of papaya leaf activity were all things we wanted to assess. The information for this review paper, which focuses mostly on the therapeutic potential of papaya leaf extract was obtained via researching a collection of wider internet databases, including Google Scholar, PubMed, Science Direct, and Elsevier. The papaya plant, which has different parts such as fruit, leaves, seeds, bark, latex, and other substances, is very important in controlling the spread of illness. Alkaloids, glycosides, tannins, saponins, and flavonoids are just a few of the bioactive constituents in this, we focused on the papaya plant leaf's anti-cancer and anti-diabetic properties. The papaya has a wide range of therapeutic qualities. Papaya is a potent remedy, according to traditional beliefs. Biological activities have been the subject of much research. In the current review, all the pharmacological applications and activities of certain chemical components are discussed

Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge

This paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to (1) assess the quality of models that can be produced from cryogenic electron microscopy (cryo-EM) maps using current modeling software, (2) evaluate reproducibility of modeling results from different software developers and users and (3) compare performance of current metrics used for model evaluation, particularly Fit-to-Map metrics, with focus on near-atomic resolution. Our findings demonstrate the relatively high accuracy and reproducibility of cryo-EM models derived by 13 participating teams from four benchmark maps, including three forming a resolution series (1.8 to 3.1 Å). The results permit specific recommendations to be made about validating near-atomic cryo-EM structures both in the context of individual experiments and structure data archives such as the Protein Data Bank. We recommend the adoption of multiple scoring parameters to provide full and objective annotation and assessment of the model, reflective of the observed cryo-EM map density

Taurine in lower concentration attenuates platelet activity

Taurine, 2-aminoethanesulphonic acid is a common ingredient of energy drinks which is very popular with young adults. Taurine in energy drinks is known to enhance muscular performance in athletes. However, caffeine in high concentrations as found in most energy drinks have also been implicated to play an adverse role leading to cardiovascular diseases (CVD). Hyper activation of platelets is one of the major risk factors of CVD. The aim of the study was to evaluate effect of taurine alone on platelet aggregation and activation of platelet surface antigens by flowcytometry. It is hypothe-sized that taurine’s antioxidant property would inhibit platelet activity. Twelve healthy, male and female, volunteers aged 20–60 years were recruited for this study. A statistically significant inhibition of platelet aggregation was observed upon stimulation with agonists adenosine diphosphate (ADP), collagen and arachidonic acid (AA) (p<0.05). The platelet surface expression of PAC1 and p-selectin induced by all three agonists also decreased compared to baseline but was not statisti-cally significant. In conclusion this study demonstrated that taurine at a concentration of 500μM (energy drinks contain approximately 31mM taurine), inhibits the platelet hyperactivity in platelet rich plasma. Further mechanistic and interven-tional studies are required to examine the pathway involved in support of beneficial role of taurine in prevention of risk factors leading to cardiovascular disorders. Synergistic effect of varying doses of caffeine and taurine will also be evaluated to obtain most effective and protective doses for energy drinks

A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk

Dietary sources of polyphenols, which are derivatives and/or isomers of flavones, isoflavones, flavonols, catechins and phenolic acids, possess antioxidant properties and therefore might be important in preventing oxidative stress-induced platelet activation and attenuating adverse haemostatic function. Free radicals, including reactive oxygen and nitrogen species, promote oxidative stress, leading to platelet hyperactivation and the risk of thrombosis. The consumption of antioxidant/polyphenol rich foods might therefore impart anti-thrombotic and cardiovascular protective effects viatheir inhibition of platelet hyperactivation or aggregation. Most commonly used anti-platelet drugs such as aspirin block the cyclooxygenase (COX)-1 pathway of platelet activation, similar to the action of antioxidants with respect to neutralising hydrogen peroxide (H2O2), with a similar effect on thromboxane production via the COX-1 pathway. Polyphenols also target various additional platelet activation pathways (e.g. by blocking platelet-ADP, collagen receptors); thus alleviating fibrinogen binding to platelet surface (GPIIb-IIIa) receptors, reducing further platelet recruitment for aggregation and inhibiting platelet degranulation. As a result of the ability of polyphenols to target additional pathways of platelet activation, they may have the potential to substitute or complement currently used anti-plateletdrugs in sedentary, obese, pre-diabetic or diabetic populations who can be resistant or sensitive to pharmacological anti-platelet therapy

The synergistic effect of taurine and caffeine on platelet activity and hemostatic function

Several studies have shown the deleterious effects of energy drinks, containing taurine and caffeine, on cardiac health. This study aimed to examine synergistic effect of taurine and caffeine on platelets and haemostasis because platelet hyperactivity is a known predictor of cardiovascular diseases. Blood from twelve healthy volunteers aged 18 – 60 years was incubated with 500 µM taurine and 700 µM caffeine individually or together. Platelet activity was evaluated using platelet aggregation assays induced by ADP and collagen, and, haemostatic function by coagulation profile testing, glucose, lipid profile and inflammation marker C- reactive protein assessment (CRP). The optimal time and doses of taurine and caffeine required to inhibit platelet hyperactivity in vitro were established. A combined action of lower doses of taurine and caffeine (T+C) inhibited platelet aggregation, induced by ADP and collagen, greater than taurine or caffeine individually (p < 0.05). Taurine and T+C increased prothrombin clotting time (PT) significantly (p < 0.05), while caffeine alone decreased PT (p <0.05). Caffeine alone increased CRP (p < 0.05). No significant change was observed in lipid parameters. These data support our hypothesis that, synergistically lower concentrations of taurine and caffeine, found in much higher concentrations in energy drinks, may be instrumental in reducing platelet activity and prolongation of clot formation

Comparative structural vibration analysis of machinery and GFRP with Al7075

The current scenario of the industries is that the major losses in efficiency of a machine are due to vibration and friction. To reduce the detrimental effects of vibration we need to decrease the frequency and amplitude of vibration or completely eliminate vibration. To do that one must quantify vibration that already occurs in machinery and structural components. Which is the aim of this paper. The intention of the paper is to obtain and characterize the vibration signature of equipment used in a company and composite material. We have designed a setup to vibrational properties composites, vibrational signature of industrial equipment .To study vibration properties, micro-electrical mechanical systems (MEMS) based accelerometers are used to measure acceleration of the material about the datum when displaced. The data obtained is processed in MATLAB using ARDUINO relayed to computer to convert the data to frequency spectra using Fast-Fourier transforms (FFT). We ultimately compared the vibrational properties of two lathes used at a metal fabrication plant operating at different Conditions and quantified the vibration results using Fast Fourier Transforms (FFT) algorithm. The vibration signatures of a composite is studied along with which various properties like Damping Coefficient, Free Vibration, GFRP, Natural Frequency applications are studied

Design and Fabrication of Automatic UPS Battery Maintenance System

The Automatic UPS Battery Maintenance System is an innovative and technologically advanced solution developed to optimize the upkeep of Uninterruptible Power Supply (UPS) battery cells. Utilizing precision sensors and real-time data analysis, the system intelligently assesses the electrolyte levels and triggers automated distilled water replenishment when necessary. By eliminating the need for manual water level checks and refilling, the system minimizes the risk of under filled batteries, which can lead to decreased battery lifespan and compromised performance. User-friendliness is a cornerstone of the system’s design. It features an intuitive interface that provides users with a comprehensive view of battery health, water levels, and system status. In the event of anomalies, the system promptly issues notifications and alerts, ensuring timely response and minimizing potential disruptions during power outages. Key advantages of the Automatic UPS Battery Maintenance System include prolonged battery lifespan through reduced plate corrosion and sulfation, consistent and uninterrupted power supply, reduced labor and time overhead, datadriven insights for informed decision-making, and environmentally responsible water usage.In conclusion, this project introduces an intelligent and efficient solution to enhance UPS battery maintenance practices. By automating the critical process of water level management, the Automatic UPS Battery Maintenance System contributes to the overall reliability and longevity of UPS batteries, making it a valuable asset for businesses and individuals reliant on continuous and dependable power supply

Comparative structural vibration analysis of machinery and GFRP with Al7075

The current scenario of the industries is that the major losses in efficiency of a machine are due to vibration and friction. To reduce the detrimental effects of vibration we need to decrease the frequency and amplitude of vibration or completely eliminate vibration. To do that one must quantify vibration that already occurs in machinery and structural components. Which is the aim of this paper. The intention of the paper is to obtain and characterize the vibration signature of equipment used in a company and composite material. We have designed a setup to vibrational properties composites, vibrational signature of industrial equipment .To study vibration properties, micro-electrical mechanical systems (MEMS) based accelerometers are used to measure acceleration of the material about the datum when displaced. The data obtained is processed in MATLAB using ARDUINO relayed to computer to convert the data to frequency spectra using Fast-Fourier transforms (FFT). We ultimately compared the vibrational properties of two lathes used at a metal fabrication plant operating at different Conditions and quantified the vibration results using Fast Fourier Transforms (FFT) algorithm. The vibration signatures of a composite is studied along with which various properties like Damping Coefficient, Free Vibration, GFRP, Natural Frequency applications are studied