475 research outputs found
Low Incidence of Contrast Induced Nephropathy after Coronary Angiography in Patients with Advanced Chronic Kidney Disease Treated with Prophylactic Continuous Veno-venous Hemofiltration
Introduction: Contrast-induced nephropathy (CIN) is associated with increased risk of in-hospital morbidity and mortality. The purpose of this study was to find out whether continuous venovenous hemofiltration (CVVH) after coronary angiography in chronic kidney disease (CKD) patients is associated with a lower incidence of CIN than that reported in the literature.
Methods: All patients with CKD who underwent coronary angiography in the Chest Disease Hospital, Kuwait, between January 2004 and December 2005 were treated by CVVH after the procedure. Renal function was assessed before and after the procedure.
Results: A total of 98 patients were enrolled in the study, 52 (53.1%) of whom were males. Their mean age was 60.7 years. Before the procedure, the mean serum creatinine level was 4.65 mg/dl and the mean creatinine clearance (Cr Cl) was 18.04 ml/min. Patients underwent CVVH for a mean duration of 21.3 hours, after a mean time-interval of 44.3 min. Their mean serum creatinine was 4.57 mg/dl at discharge (within the first week after the procedure) and 4.78 mg/dl at 15 days after the procedure. Mean Cr Cl was 18.52 ml/min at discharge and 17.62 ml/min at 15 days after the procedure. There was no statistically significant difference between the mean serum creatinine and Cr Cl values before and after the procedure. However, one patient (1.02%) developed CIN and ended on regular hemodialysis. The in-hospital mortality was 0%.
Conclusion: Patients with advanced CKD who undergo coronary angiography may be protected from further deterioration in their renal function after exposure to radiological contrast material if the procedure is immediately followed by CVVH. A randomized controlled clinical trial is needed to verify our encouraging results.
Keywords: contrast induced nephropathy, chronic kidney disease, continuous venovenous hemofiltratio
Effects of dietary supplementation of soybean lecithin on growth performance, nutrients digestibility and serum profiles of broilers fed fried soybean oil
The objective of this study was to evaluate the effects of soybean lecithin in broiler diets formulated with either fried or non-fried soybean oils (as an energy source), on growth performance, digestibility, and some serum parameters. A total of 600 broilers (50% male) were assigned to 4 experimental groups (with 10 replicates of 15 birds each): (i) group (S) fed with soybean oil only, (ii) group (SL) fed with soybean oil + lecithin (0.035% in feed), (iii) group (F) fed with fried soybean oil only, and iv) group (FL) fed with fried soybean oil + lecithin (0.035% in feed). The results showed that fried soybean oil in broilers diets had the same effects on the analysed parameters as the non-fried oil. Broilers that received lecithin with fried soybean oil (group FL) exhibited significantly higher body weights (1.228 vs. 1.210, p<0.05 and 1.935 vs. 1.917 kg, p<0.05) than group F in the last two experimental periods (22-28 and 29-35 d), respectively. On the contrary, the addition of soybean lecithin to diets formulated with either fried or non-fried soybean oil resulted in a significant increase in weight of some carcass cuts (thigh, breast) and a significant decrease in some visceral organs (intestine, liver, viscera), without affecting the digestibility parameters here assessed. Our findings revealed that the addition of soybean lecithin to standard soybean oil (group SL) significantly decreased serum TG (77.16 vs. 83.46, p<0.05) compared to group S. In conclusion, it was possible to use recovered frying soybean oil in broiler diets without a negative impact on growth performance and serum triglyceride level, while these parameters were improved by the addition of soybean lecithin
Creation of super-high-flux photo-neutrons and gamma-rays > 8 MeV using a petawatt laser to irradiate high-Z solid targets
We report the creation of super-high-flux gamma-rays with energy >8 MeV and
photo-neutrons via the (g,n) reaction near giant dipole resonance energies (8 -
20 MeV), using the ~130 J Texas Petawatt laser to irradiate high-Z (Au, Pt, Re,
W) targets of mm - cm thickness, at laser intensities up to ~5x1021W/cm2. We
detected up to ~ several x 1012 gamma-rays > 8 MeV (~3% of incident laser
energy) and ~ 1010 photo-neutrons per shot. Due to the short pulse and narrow
gamma-ray cone (~17o half-width) around laser forward, the peak emergent
gamma-ray flux >8 MeV reached ~1027 gammas/cm2/sec, and the peak emergent
neutron flux reached ~1020 neutrons/cm2/sec. Such intense gamma-ray and neutron
fluxes are among the highest achieved for short-pulse laser experiments. They
will facilitate the study of nuclear reactions requiring super-high-flux of
gamma-rays or neutrons, such as the creation of r-process elements. These
results may also have far-reaching applications for nuclear energy, such as the
transmutation of nuclear waste.Comment: 16 pages, 9 figure
Advances in surface EMG signal simulation with analytical and numerical descriptions of the volume conductor
Surface electromyographic (EMG) signal modeling is important for signal interpretation, testing of processing algorithms, detection system design, and didactic purposes. Various surface EMG signal models have been proposed in the literature. In this study we focus on 1) the proposal of a method for modeling surface EMG signals by either analytical or numerical descriptions of the volume conductor for space-invariant systems, and 2) the development of advanced models of the volume conductor by numerical approaches, accurately describing not only the volume conductor geometry, as mainly done in the past, but also the conductivity tensor of the muscle tissue. For volume conductors that are space-invariant in the direction of source propagation, the surface potentials generated by any source can be computed by one-dimensional convolutions, once the volume conductor transfer function is derived (analytically or numerically). Conversely, more complex volume conductors require a complete numerical approach. In a numerical approach, the conductivity tensor of the muscle tissue should be matched with the fiber orientation. In some cases (e.g., multi-pinnate muscles) accurate description of the conductivity tensor may be very complex. A method for relating the conductivity tensor of the muscle tissue, to be used in a numerical approach, to the curve describing the muscle fibers is presented and applied to representatively investigate a bi-pinnate muscle with rectilinear and curvilinear fibers. The study thus propose an approach for surface EMG signal simulation in space invariant systems as well as new models of the volume conductor using numerical methods
Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan
INTRODUCTION: Although breast carcinoma (BC) is the most common malignancy affecting Jordanian females and the affected population in Jordan is younger than that in the West, no information is available on its biological characteristics. Our aims in this study are to evaluate the expression of estrogen receptor (ER) and progesterone receptor (PR) and Her-2/neu overexpression in BC in Jordan, and to compare the expression of these with other prognostic parameters for BC such as histological type, histological grade, tumor size, patients' age, and number of lymph node metastases. METHOD: This is a retrospective study conducted in the Department of Pathology at Jordan University of Science and Technology. A confirmed 91 cases of BC diagnosed in the period 1995 to 1998 were reviewed and graded. We used immunohistochemistry to evaluate the expression of ER, PR, and Her-2. Immunohistochemical findings were correlated with age, tumor size, grade and axillary lymph node status. RESULTS: Her-2 was overexpressed in 24% of the cases. The mean age of Her-2 positive cases was 42 years as opposed to 53 years among Her-2 negative cases (p = 0.0001). Her-2 expression was inversely related to ER and PR expression. Her-2 positive tumors tended to be larger than Her-2 negative tumors with 35% overexpression among T3 tumors as opposed to 22% among T2 tumors (p = 0.13). Her-2 positive cases tended to have higher rates of axillary metastases, but this did not reach statistical significance. ER and PR positive cases were seen in older patients with smaller tumor sizes. CONCLUSION: Her-2 overexpression was seen in 24% of BC affecting Jordanian females. Her-2 overexpression was associated with young age at presentation, larger tumor size, and was inversely related to ER and PR expression. One-fifth of the carcinomas were Her-2 positive and ER negative. This group appears to represent an aggressive form of BC presenting at a young age with large primary tumors and a high rate of four or more axillary lymph node metastases
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Geographic information retrieval in a mobile environment: evaluating the needs of mobile individuals
This paper describes research that aims to define the information needs of mobile individuals, to implement a mobile information system that can satisfy those needs, and finally to evaluate the performance of that system with end-users. First a review of the emerging discipline of geographic information retrieval (GIR) is presented as background to the more specific issue of mobile information retrieval. Following this, a user needs study is described evaluating the requirements of potential users of a mobile information system; the study finds that there is a strong geographic component to users' information needs. Next, four geographic post-query filters are described which attempt to represent the region of space associated with an individual's query made at some specific spatial location. These filters are spatial proximity (distance in space), temporal proximity (travel time), speed-heading prediction surfaces (likelihood of visiting locations) and visibility (locations that can be seen). Two of these filters — spatial proximity and speed-heading prediction surfaces — are implemented in a mobile information system and subsequently evaluated with users in an outdoor setting. The results of evaluation suggest that retrieved information to which post-query geographic filters have been applied is considered more relevant than unfiltered information, and that users find information sorted by spatial proximity to be more relevant than that sorted by a prediction surface of likely future locations. The paper closes with a discussion of the wider implications of these results for developers of mobile information systems and location-based services
Assessment of personal care and medical robots from older adults' perspective
Demographic reports indicate that population of older adults is growing significantly over the world and in particular in developed nations. Consequently, there are a noticeable number of demands for certain services such as health-care systems and assistive medical robots and devices. In today's world, different types of robots play substantial roles specifically in medical sector to facilitate human life, especially older adults. Assistive medical robots and devices are created in various designs to fulfill specific needs of older adults. Though medical robots are utilized widely by senior citizens, it is dramatic to find out into what extent assistive robots satisfy their needs and expectations. This paper reviews various assessments of assistive medical robots from older adults' perspectives with the purpose of identifying senior citizen's needs, expectations, and preferences. On the other hand, these kinds of assessments inform robot designers, developers, and programmers to come up with robots fulfilling elderly's needs while improving their life quality
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Bioavailability in soils
The consumption of locally-produced vegetables by humans may be an important exposure pathway for soil contaminants in many urban settings and for agricultural land use. Hence, prediction of metal and metalloid uptake by vegetables from contaminated soils is an important part of the Human Health Risk Assessment procedure. The behaviour of metals (cadmium, chromium, cobalt, copper, mercury, molybdenum, nickel, lead and zinc) and metalloids (arsenic, boron and selenium) in contaminated soils depends to a large extent on the intrinsic charge, valence and speciation of the contaminant ion, and soil properties such as pH, redox status and contents of clay and/or organic matter. However, chemistry and behaviour of the contaminant in soil alone cannot predict soil-to-plant transfer. Root uptake, root selectivity, ion interactions, rhizosphere processes, leaf uptake from the atmosphere, and plant partitioning are important processes that ultimately govern the accumulation ofmetals and metalloids in edible vegetable tissues. Mechanistic models to accurately describe all these processes have not yet been developed, let alone validated under field conditions. Hence, to estimate risks by vegetable consumption, empirical models have been used to correlate concentrations of metals and metalloids in contaminated soils, soil physico-chemical characteristics, and concentrations of elements in vegetable tissues. These models should only be used within the bounds of their calibration, and often need to be re-calibrated or validated using local soil and environmental conditions on a regional or site-specific basis.Mike J. McLaughlin, Erik Smolders, Fien Degryse, and Rene Rietr
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