Aspergillus niger: an unusual cause of invasive pulmonary aspergillosis

Infections due to Aspergillus species cause significant morbidity and mortality. Most are attributed to Aspergillus fumigatus, followed by Aspergillus flavus and Aspergillus terreus. Aspergillus niger is a mould that is rarely reported as a cause of pneumonia. A 72-year-old female with chronic obstructive pulmonary disease and temporal arteritis being treated with steroids long term presented with haemoptysis and pleuritic chest pain. Chest radiography revealed areas of heterogeneous consolidation with cavitation in the right upper lobe of the lung. Induced bacterial sputum cultures, and acid-fast smears and cultures were negative. Fungal sputum cultures grew A. niger. The patient clinically improved on a combination therapy of empiric antibacterials and voriconazole, followed by voriconazole monotherapy. After 4 weeks of voriconazole therapy, however, repeat chest computed tomography scanning showed a significant progression of the infection and near-complete necrosis of the right upper lobe of the lung. Serum voriconazole levels were low–normal (1.0 μg ml−1, normal range for the assay 0.5–6.0 μg ml−1). A. niger was again recovered from bronchoalveolar lavage specimens. A right upper lobectomy was performed, and lung tissue cultures grew A. niger. Furthermore, the lung histopathology showed acute and organizing pneumonia, fungal hyphae and oxalate crystallosis, confirming the diagnosis of invasive A. niger infection. A. niger, unlike A. fumigatus and A. flavus, is less commonly considered a cause of invasive aspergillosis (IA). The finding of calcium oxalate crystals in histopathology specimens is classic for A. niger infection and can be helpful in making a diagnosis even in the absence of conidia. Therapeutic drug monitoring may be useful in optimizing the treatment of IA given the wide variations in the oral bioavailability of voriconazole

SOXS: a wide band spectrograph to follow up transients

SOXS (Son Of X-Shooter) will be a spectrograph for the ESO NTT telescope capable to cover the optical and NIR bands, based on the heritage of the X-Shooter at the ESO-VLT. SOXS will be built and run by an international consortium, carrying out rapid and longer term Target of Opportunity requests on a variety of astronomical objects. SOXS will observe all kind of transient and variable sources from different surveys. These will be a mixture of fast alerts (e.g. gamma-ray bursts, gravitational waves, neutrino events), mid-term alerts (e.g. supernovae, X-ray transients), fixed time events (e.g. close-by passage of minor bodies). While the focus is on transients and variables, still there is a wide range of other astrophysical targets and science topics that will benefit from SOXS. The design foresees a spectrograph with a Resolution-Slit product ~ 4500, capable of simultaneously observing over the entire band the complete spectral range from the U- to the H-band. The limiting magnitude of R~20 (1 hr at S/N~10) is suited to study transients identified from on-going imaging surveys. Light imaging capabilities in the optical band (grizy) are also envisaged to allow for multi-band photometry of the faintest transients. This paper outlines the status of the project, now in Final Design Phase.Comment: 12 pages, 14 figures, to be published in SPIE Proceedings 1070

SOXS End-to-End simulator: development and applications for pipeline design

We present the development of the End-to-End simulator for the SOXS instrument at the ESO-NTT 3.5-m telescope. SOXS will be a spectroscopic facility, made by two arms high efficiency spectrographs, able to cover the spectral range 350-2000 nm with resolving power R=4500. The E2E model allows to simulate the propagation of photons starting from the scientific target of interest up to the detectors. The outputs of the simulator are synthetic frames, which will be mainly exploited for optimizing the pipeline development and possibly assisting for proper alignment and integration phases in laboratory and at the telescope. In this paper, we will detail the architecture of the simulator and the computational model, which are strongly characterized by modularity and flexibility. Synthetic spectral formats, related to different seeing and observing conditions, and calibration frames to be ingested by the pipeline are also presented

Son of X--Shooter: a multi--band instrument for a multi--band universe

Son Of X-Shooter (SOXS) will be a new instrument designed to be mounted at the Nasmyth--A focus of the ESO 3.5 m New Technology Telescope in La Silla site (Chile). SOXS is composed of two high-efficiency spectrographs with a resolution slit product 4500, working in the visible (350 -- 850 nm) and NIR (800 -- 2000 nm) range respectively, and a light imager in the visible (the acquisition camera usable also for scientific purposes). The science case is very broad, it ranges from moving minor bodies in the solar system, to bursting young stellar objects, cataclysmic variables and X-ray binary transients in our Galaxy, supernovae and tidal disruption events in the local Universe, up to gamma-ray bursts in the very distant and young Universe, basically encompassing all distance scales and astronomy branches. At the moment, the instrument passed the Preliminary Design Review by ESO (July 2017) and the Final Design (with FDR in July 2018).Comment: 23 pages, 10 Figures, accepted to be published in Frontier Research in Astrophysics 2018 Conference proceedings in Proceeding of Science. arXiv admin note: text overlap with arXiv:1807.0882