55 research outputs found

    Preventing transition to turbulence: a viscosity stratification does not always help

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    In channel flows a step on the route to turbulence is the formation of streaks, often due to algebraic growth of disturbances. While a variation of viscosity in the gradient direction often plays a large role in laminar-turbulent transition in shear flows, we show that it has, surprisingly, little effect on the algebraic growth. Non-uniform viscosity therefore may not always work as a flow-control strategy for maintaining the flow as laminar.Comment: 9 pages, 8 figure

    Toward a Regulatory Pathway for the Use of in Silico Trials in The Ce Marking of Medical Devices

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    In Silico Trials methodologies will play a growing and fundamental role in the development and de-risking of new medical devices in the future. While the regulatory pathway for Digital Patient and Personal Health Forecasting solutions is clear, it is more complex for In Silico Trials solutions, and therefore deserves a deeper analysis. In this position paper, we investigate the current state of the art towards the regulatory system for in silico trials applied to medical devices while exploring the European regulatory system toward this topic. We suggest that the European regulatory system should start a process of innovation: in principle to limit distorted quality by different internal processes within notified bodies, hence avoiding that the more innovative and competitive companies focus their attention on the needs of other large markets, like the USA, where the use of such radical innovations is already rapidly developing

    Effectiveness of a single-session early psychological intervention for children after road traffic accidents: a randomised controlled trial

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    BACKGROUND: Road traffic accidents (RTAs) are the leading health threat to children in Europe, resulting in 355,000 injuries annually. Because children can suffer significant and long-term mental health problems following RTAs, there is considerable interest in the development of early psychological interventions. To date, the research in this field is scarce, and currently no evidence-based recommendations can be made. METHODS: To evaluate the effectiveness of a single-session early psychological intervention, 99 children age 7-16 were randomly assigned to an intervention or control group. The manualised intervention was provided to the child and at least one parent around 10 days after the child's involvement in an RTA. It included reconstruction of the accident using drawings and accident-related toys, and psychoeducation. All of the children were interviewed at 10 days, 2 months and 6 months after the accident. Parents filled in questionnaires. Standardised instruments were used to assess acute stress disorder (ASD), posttraumatic stress disorder (PTSD), depressive symptoms and behavioural problems. RESULTS: The children of the two study groups showed no significant differences concerning posttraumatic symptoms and other outcome variables at 2 or at 6 months. Interestingly, analyses showed a significant intervention x age-group effect, indicating that for preadolescent children the intervention was effective in decreasing depressive symptoms and behavioural problems. CONCLUSIONS: This study is the first to show a beneficial effect of a single-session early psychological intervention after RTA in preadolescent children. Therefore, an age-specific approach in an early stage after RTAs may be a promising way for further research. Younger children can benefit from the intervention evaluated here. However, these results have to be interpreted with caution, because of small subgroup sizes. Future studies are needed to examine specific approaches for children and adolescents. Also, the intervention evaluated here needs to be studied in other groups of traumatised children. TRIAL REGISTRATION: Clinical Trial Registry: ClinicalTrials.gov: NCT00296842

    Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment

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    Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums

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    International Study Group Progress Report On Linear Collider Development

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    Persuasion architectures: Consumer spaces, affective engineering and (criminal) harm

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    Drawing together recent theoretical work from both within and beyond criminology, this article considers the role of strategically designed consumer spaces in eliciting potentially criminogenic and harmful dispositions and behaviours. First, the article introduces recent work in cultural geography and urban studies, which has drawn attention to the manipulation of affect through spatial design. Second, by way of example, the article considers how such strategies are deployed in three types of consumer environments: shopping malls and retail spaces; casinos and other gambling environments; and the so-called night time economy. Third, the article engages such developments theoretically. It is suggested we rethink the distinctions and interrelationships between human subjectivity and agency and the built environment. The implications of this proposed conceptual reorientation are explored – first, for our understandings of agency, intentionality, moral responsibility and political accountability; and second, for criminological thinking around embodied difference, power and exclusio
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