5,365 research outputs found
Human interleukin-1 receptor antagonist is expressed in liver
AbstractUsing PCR and Northern blot analysis, an IL-1 receptor antagonist specific transcript was amplified from HepG2- and liver mRNA, cDNA clones coding for IL-1 receptor antagonist were isolated from a liver cDNA library and sequence comparison revealed complete identity with the secreted, monocytic form of IL-1 receptor antagonist
Understanding the fidelity effect when evaluating games with children
There have been a number of studies that have compared evaluation results from prototypes of different fidelities but very few of these are with children. This paper reports a comparative study of three prototypes ranging from low fidelity to high fidelity within the context of mobile games, using a between subject design with 37 participants aged 7 to 9. The children played a matching game on either an iPad, a paper prototype using screen shots of the actual game or a sketched version. Observational data was captured to establish the usability problems, and two tools from the Fun Toolkit were used to measure user experience. The results showed that there was little difference for user experience between the three prototypes and very few usability problems were unique to a specific prototype. The contribution of this paper is that children using low-fidelity prototypes can effectively evaluate games of this genre and style
A Robust Exponentially Weighted Moving Average Control Chart for the Process Mean
To date, numerous extensions of the exponentially weighted moving average, EWMA charts have been made. A new robust EWMA chart for the process mean is proposed. It enables easier detection of outliers and increase sensitivity to other forms of out-of-control situation when outliers are present
Electron interactions in an antidot in the integer quantum Hall regime
A quantum antidot, a submicron depletion region in a two-dimensional electron
system, has been actively studied in the past two decades, providing a powerful
tool for understanding quantum Hall systems. In a perpendicular magnetic field,
electrons form bound states around the antidot. Aharonov-Bohm resonances
through such bound states have been experimentally studied, showing interesting
phenomena such as Coulomb charging, h/2e oscillations, spectator modes,
signatures of electron interactions in the line shape, Kondo effect, etc. None
of them can be explained by a simple noninteracting electron approach.
Theoretical models for the above observations have been developed recently,
such as a capacitive-interaction model for explaining the h/2e oscillations and
the Kondo effect, numerical prediction of a hole maximum-density-droplet
antidot ground state, and spin density-functional theory for investigating the
compressibility of antidot edges. In this review, we summarize such
experimental and theoretical works on electron interactions in antidots.Comment: 73 pages, 28 figures, to be published in Physics Reports. The
resolution of some figures is reduced in this uploa
Constraints on explosive silicon burning in core-collapse supernovae from measured Ni/Fe ratios
Measurements of explosive nucleosynthesis yields in core-collapse supernovae
provide tests for explosion models. We investigate constraints on explosive
conditions derivable from measured amounts of nickel and iron after radioactive
decays using nucleosynthesis networks with parameterized thermodynamic
trajectories. The Ni/Fe ratio is for most regimes dominated by the production
ratio of 58Ni/(54Fe + 56Ni), which tends to grow with higher neutron excess and
with higher entropy. For SN 2012ec, a supernova that produced a Ni/Fe ratio of
times solar, we find that burning of a fuel with neutron excess
is required. Unless the progenitor metallicity
is over 5 times solar, the only layer in the progenitor with such a neutron
excess is the silicon shell. Supernovae producing large amounts of stable
nickel thus suggest that this deep-lying layer can be, at least partially,
ejected in the explosion. We find that common spherically symmetric models of
Msun stars exploding with a delay time of less than
one second ( Msun) are able to achieve such silicon-shell
ejection. Supernovae that produce solar or sub-solar Ni/Fe ratios, such as SN
1987A, must instead have burnt and ejected only oxygen-shell material, which
allows a lower limit to the mass cut to be set. Finally, we find that the
extreme Ni/Fe value of 60-75 times solar derived for the Crab cannot be
reproduced by any realistic-entropy burning outside the iron core, and
neutrino-neutronization obtained in electron-capture models remains the only
viable explanation.Comment: 13 pages, 9 figures, accepted for publication in Ap
The peculiar Type Ia supernova iPTF14atg: Chandrasekhar-mass explosion or violent merger?
iPTF14atg, a subluminous peculiar Type Ia supernova (SN Ia) similar to SN
2002es, is the first SN Ia for which a strong UV flash was observed in the
early-time light curves. This has been interpreted as evidence for a
single-degenerate (SD) progenitor system where such a signal is expected from
interactions between the SN ejecta and the non-degenerate companion star. Here,
we compare synthetic observables of multi-dimensional state-of-the-art
explosion models for different progenitor scenarios to the light curves and
spectra of iPTF14atg. From our models, we have difficulties explaining the
spectral evolution of iPTF14atg within the SD progenitor channel. In contrast,
we find that a violent merger of two carbon-oxygen white dwarfs with 0.9 and
0.76 solar masses, respectively, provides an excellent match to the spectral
evolution of iPTF14atg from 10d before to several weeks after maximum light.
Our merger model does not naturally explain the initial UV flash of iPTF14atg.
We discuss several possibilities like interactions of the SN ejecta with the
circum-stellar medium and surface radioactivity from a He ignited merger that
may be able to account for the early UV emission in violent merger models.Comment: 12 pages, 7 figures, accepted for publication in MNRA
A Droplet State in an Interacting Two-Dimensional Electron System
It is well known that the dielectric constant of two-dimensional (2D)
electron system goes negative at low electron densities. A consequence of the
negative dielectric constant could be the formation of the droplet state. The
droplet state is a two-phase coexistence region of high density liquid and low
density "gas". In this paper, we carry out energetic calculations to study the
stability of the droplet ground state. The possible relevance of the droplet
state to recently observed 2D metal-insulator transition is also discussed.Comment: 4 pages, 4 figures. To appear in Phys. Rev. B (Rapid Communications
Thrombus Formation: Direct Real‐Time Observation and Digital Analysis of Thrombus Assembly in a Living Mouse by Confocal and Widefield Intravital Microscopy
We have developed novel instrumentation using confocal and widefield microscopy to image and analyze thrombus formation in real time in the microcirculation of a living mouse. This system provides high-speed, near-simultaneous acquisition of images of multiple fluorescent probes and a brightfield channel, and supports laser-induced injury through the microscope optics. Although this imaging facility requires interface of multiple hardware components, the primary challenge in vascular imaging is careful experimental design and interpretation. This system has been used to localize tissue factor during thrombus formation, to observe defects in thrombus assembly in genetically altered mice, to study the kinetics of platelet activation and P-selectin expression following vascular injury, to analyze leukocyte rolling on arterial thrombi, to generate three-dimensional models of thrombi, and to analyze the effect of antithrombotic agents in vivo
CMS endcap RPC gas gap production for upgrade
The CMS experiment will install a RE4 layer of 144 new Resistive Plate Chambers (RPCs) on the existing york YE3 at both endcap regions to trigger high momentum muons from the proton-proton interaction. In this paper, we present the detailed procedures used in the production of new RPC gas gaps adopted in the CMS upgrade. Quality assurance is enforced as ways to maintain the same quality of RPC gas gaps as the existing 432 endcap RPC chambers that have been operational since the beginning of the LHC operation
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