O papel da mãe no tratamento de criança com recidiva de câncer

O câncer no Brasil representa a primeira causa de morte (8% do total) por doença entre crianças e adolescentes de 1 a 19 anos, segundo o Instituto Nacional de Câncer [1]. Ao mesmo tempo em que pode haver boa chance de sobrevivência quando a doença é detectada precocemente, de outra parte a recidiva do câncer é impactante. Nesse momento de recomeço, a mãe do paciente possui papel de destaque, pois sabe-se que os indivíduos envolvidos nesse contexto são vulneráveis e que prevalecem sentimentos de falta de controle da situação, perplexidade e ansiedade. Percebe-se o caráter multidisciplinar (da psicologia, da bioética, da saúde) e pluralista do assunto, tal como preceituado no artigo 2° da Declaração Universal sobre Bioética e Direitos Humanos, da UNESCO. Método: a pesquisa proposta tem como fundamento a análise do papel da mãe no tratamento da criança com recidiva de câncer. Trata-se de um ensaio reflexivo sobre o tema, à luz da Declaração Universal sobre Bioética e Direitos Humanos, da UNESCO

Transmon in a semi-infinite high-impedance transmission line: Appearance of cavity modes and Rabi oscillations

In this paper, we investigate the dynamics of a single superconducting artificial atom capacitively coupled to a transmission line with a characteristic impedance comparable to or larger than the quantum resistance. In this regime, microwaves are reflected from the atom also at frequencies far from the atom\u27s transition frequency. Adding a single mirror in the transmission line then creates cavity modes between the atom and the mirror. Investigating the spontaneous emission from the atom, we then find Rabi oscillations, where the energy oscillates between the atom and one of the cavity modes

Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength

Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development. Serum samples (n = 408) from young overweight subjects (n = 143) were collected during a lifestyle intervention study. Anthropometric parameters, along with leptin, IGF1 and IGF1R-aAb concentrations, were analyzed, and the subjects were categorized into positive or negative for IGF1R-aAb. Eleven out of 143 subjects (7.7%) were positive for IGF1R-aAb. Identified IGF1R-aAb were molecularly characterized and showed antagonistic activity in vitro impairing IGF1-mediated IGF1R activation. Mean body weight, height or age were similar between IGF1R-aAb-positive and -negative subjects, but IGF1 concentrations differed. Jumping ability, as well as right and left handgrip strengths, were lower in the IGF1R-aAb-positive as compared to the IGF1R-aAb-negative subjects. We conclude that natural IGF1R-aAb are detectable in apparently healthy subjects and are capable of antagonizing IGF1-dependent IGF1R activation. Moreover, the presence of IGF1R-aAb is associated with poor physical strength. Although the causality of this association is unclear, the data imply a potential influence of IGF1R autoimmunity on muscle development

Methods of editing cloud and atmospheric layer affected pixels from satellite data

The location and migration of cloud, land and water features were examined in spectral space (reflective VIS vs. emissive IR). Daytime HCMM data showed two distinct types of cloud affected pixels in the south Texas test area. High altitude cirrus and/or cirrostratus and "subvisible cirrus" (SCi) reflected the same or only slightly more than land features. In the emissive band, the digital counts ranged from 1 to over 75 and overlapped land features. Pixels consisting of cumulus clouds, or of mixed cumulus and landscape, clustered in a different area of spectral space than the high altitude cloud pixels. Cumulus affected pixels were more reflective than land and water pixels. In August the high altitude clouds and SCi were more emissive than similar clouds were in July. Four-channel TIROS-N data were examined with the objective of developing a multispectral screening technique for removing SCi contaminated data

Pacemaker implantation in small hospitals: complication rates comparable to larger centres

Some countries have a demography that makes it necessary to maintain relatively small pacemaker centres. We wanted to assess the quality of pacemaker surgery in two such hospitals. Through patient records we gathered information on ∼535 consecutive primary pacemaker implantations in two small pacemaker centres with 30 and 80 annual operations, respectively. All patients were followed for 3 years. All complications documented in the patient records were registered. Furthermore, we performed a non-systematic literature search comparing our data with reports from major centres published over the last 10 years.We found 72 complications in 64 (12.0%) of the patients, the most common being bleeding, lead failure, and pneumothorax. If minor bleedings without any consequences for the patients are excluded, the number of complications was 46 in 40 patients (7.5%). We had to reoperate on 5.2% of the patients. There was no statistically significant difference in complication rates between the two hospitals. Education candidates generated statistically significant more complications than experienced doctors (13.7 vs. 7.1%, P < 0.05). There are no generally accepted norms of complication rates in pacemaker surgery. However, we found no indications that our centres have a rate of complications that is unacceptably high