Literatura eclesiástica en torno al Concilio Vaticano I

Desde una perspectiva global de los escritos dogmáticos del Vaticano I, este estudio analiza las fuentes y obras de carácter general distribuidas en tres sesiones cronológicas. Por otra parte, se analizan los escritos de los tiempos coetáneos del Concilio desde 1869 a 1900. Se abordan, además, las ideas conciliares dentro de las luchas ideológicas que se llevaron a cabo en la primera mitad del siglo XX. Para concluir, se contemplan los últimos escritos publicados que giran ya en la órbita del Concilio Vaticano II

Congreso Eucarístico Nacional

Del 17 al 23 de junio se celebró en Sevilla el séptimo Congreso Eucarístico Nacional de España y el primero después del Concilio Vaticano II. La siguiente nota señala los principales momentos y contenidos de dicha celebración

Congreso Eucarístico Nacional: Sesiones de estudio

Del 17 al 23 de junio se celebró en Sevilla el séptimo Congreso Eucarístico Nacional de España y el primero después del Concilio Vaticano II. La siguiente nota señala los principales momentos y contenidos de dicha celebración

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2

The t(7;11)(p15;p15.4) has been reported to fuse the NUP98 gene (11p15), a component of the nuclear pore complex, with the class-1 homeobox gene HOXA9 at 7p15. This translocation has been associated with myeloid leukemias, predominantly acute myeloid leukemia (AML) M2 subtype with trilineage myelodysplastic features, and with a poor prognosis. The derived fusion protein retains the FG repeat motif of NUP98 N-terminus and the homeodomain shared by the HOX genes, acting as an oncogenic transcription factor critical for leukemogenesis. We report here a new complex t(7;11)-variant, i.e., t(7;11;13;17)(p15;p15;p?;p1?2) in a patient with AML-M2 and poor prognosis. The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias. No other fusion transcripts involving the NUP98 or HOXA9 genes were present, although other mechanisms involving several genes on chromosomes 13 and 17 may also be involved. To our knowledge, this is the first t(7;11) variant involving NUP98 described in hematological malignancies

The prevalence of metabolic syndrome in Latin America: a systematic review

Objective To assess the available data on the prevalence of metabolic syndrome (MS) in Latin-American countries.Design Systematic review. Searches were carried out in PubMed, ISIWeb, SCielo and Redalyc, using ?metabolic syndrome x' and ?prevalence' as keywords for titles and/or abstracts. Articles selected were cross-sectional studies in Latin-American countries, whose main objective was to study MS and whose study population is described below. MS must be determined using Adult Treatment Panel III criteria. Twelve studies with these criteria were selected, one of which was multi-centric.Setting Latin America.Subjects Apparently healthy subjects aged 18-65 years (including young adult, mature adult and elderly populations) of both genders.Results The general prevalence (weighted mean) of MS in Latin-American countries was 24.9 (range: 18.8-43.3) %. MS was slightly more frequent in women (25.3 %) than in men (23.2 %), and the age group with the highest prevalence of MS consisted of those over 50 years of age. The most frequent components of MS were low HDL cholesterol levels (62.9 %) and abdominal obesity (45.8 %). Similar outcomes were obtained from the multi-centre study on Latin-American populations analysed.Conclusions The present review brings us closer to an understanding of the prevalence of MS in Latin-American countries. However, it is not possible to know the full scope of the problem, partly because data from some countries are not available, and because the methodological differences among the studies published up to the present limit a joint analysis of their results. Copyright © The Authors 2011

Implications of early respiratory support strategies on disease progression in critical COVID-19 : a matched subanalysis of the prospective RISC-19-ICU cohort

Background: Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU) mortality rates. Methods: Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, according to the respiratory support strategy employed at the day of admission to ICU. Propensity score matching was performed to ensure comparability between groups. Results: Initially, 1421 patients were assessed for possible study inclusion. Of these, 351 patients (85 SOT, 87 HFNC, 87 NIV, and 92 IMV) remained eligible for full analysis after propensity score matching. 55% of patients initially receiving noninvasive respiratory support required IMV. The intubation rate was lower in patients initially ventilated with HFNC and NIV compared to those who received SOT (SOT: 64%, HFNC: 52%, NIV: 49%, p = 0.025). Compared to the other respiratory support strategies, NIV was associated with a higher overall ICU mortality (SOT: 18%, HFNC: 20%, NIV: 37%, IMV: 25%, p = 0.016). Conclusion: In this cohort of critically ill patients with COVID-19, a trial of HFNC appeared to be the most balanced initial respiratory support strategy, given the reduced intubation rate and comparable ICU mortality rate. Nonetheless, considering the uncertainty and stress associated with the COVID-19 pandemic, SOT and early IMV represented safe initial respiratory support strategies. The presented findings, in agreement with classic ARDS literature, suggest that NIV should be avoided whenever possible due to the elevated ICU mortality risk