Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Energy and spatial reuse efficient network-wide real-time data broadcasting in mobile ad hoc networks

Abstract—In this paper, we present NB-TRACE, which is an energy-efficient network-wide voice broadcasting architecture for mobile ad hoc networks. In the NB-TRACE architecture, the network is organized into overlapping clusters through a distributed algorithm, where the clusterheads create a nonconnected dominating set. Channel access is regulated through a distributed TDMA scheme maintained by the clusterheads. The first group of packets of a broadcast session is broadcast through flooding, where each data rebroadcast is preceded by an acknowledgment to the upstream node. Nodes that do not get an acknowledgment for a predetermined time, except the clusterheads, cease to rebroadcast, which prunes the redundant retransmissions. The connected dominating set formed through this basic algorithm is broken in time due to node mobility. The network responds to the broken links through multiple mechanisms to ensure the maintenance of the connected dominating set. We compare NB-TRACE with four network layer broadcast routing algorithms (Flooding, Gossiping, Counter-based broadcasting, and Distance-based broadcasting) and three medium access control protocols (IEEE 802.11, SMAC, and MH-TRACE) through extensive ns-2 simulations. Our results show that NB-TRACE outperforms other network/MAC layer combinations in minimizing energy dissipation and optimizing spatial reuse, while producing competitive QoS performance. Index Terms—Low-power design, energy-aware systems, data communications, distributed protocols, network communications, network topology, wireless communication, network protocols, protocol architecture, protocol verification, routing protocols, access schemes, mobile computing, algorithm/protocol design and analysis, mobile communication systems.

Mobility Helps Energy Balancing in Wireless Networks

AFCEA;IEEE Communications Society2013 IEEE Military Communications Conference, MILCOM 2013 -- 18 November 2013 through 20 November 2013 -- San Diego, CA -- 103026In this paper, we investigate the effects of mobility on the energy dissipation characteristics of wireless networks. We construct a Linear Programming (LP) framework that jointly captures data routing, mobility, and energy dissipation aspects and explore the design space by performing numerical analysis using the developed LP framework. Our results show that mobility has significant effects on the energy dissipation trends of wireless nodes. Mobility can improve the energy balancing up to a certain level, however extreme mobility may lead to a degradation in energy balancing, and thus energy efficiency of wireless networks. © 2013 IEEE