Relevance Of Ancient Indian Methods Of Environmental Protection In The Present Day Scenario

“The greatest shortcoming of human race is our inability to understand the exponential function” -Albert.A.Bartlett In a bid to achieve the twin goals of boosting economic growth and ending extreme poverty, nations have exploited the existing resources without understanding the true cost of its depletion. They are confronted with a resource scarcity crisis as they are unable to satisfy the unlimited wants of human beings with the limited resources. Resources have been used, abused and misused over and above their rate of replenishment. At this juncture, it becomes imperative for nations to understand the concept of “Sustainable Development”. Sustainable development refers to development that meets the needs of the present generation without compromising the ability of future generations to meet their own needs. The questions for nations is not “whether” to embrace sustainable development but “how” to embrace it. The answer lies in an older school of thought. In ancient India, the inhabitants of the river Indus(Hindus)followed certain practices that were environment friendly with or without their knowledge. They embraced nature as an integral part of their life. Hindus have long had a palpable and organic connection with nature. In this paper, “Hinduism” is considered as “a way oflife”thatwaspracticedbyourforefathersand not merely as a religion. Ancient Indian texts like Vedas, Puranas and Upanishads clearly describe the eco-friendly attitude of Hindus. Plants and trees are valued so highly in Hindu sacred texts that their destruction is connected with doomsday scenario. For the same reason, almost every temple in South India dedicated to Lord Shiva or Vishnu, or to a manifestation of the goddess, has a “sthalavriksha”, a special tree regarded as sacred to that area. The sthalavriksha symbolizes all trees and reminds pilgrims that all trees are worthy of respect. Similarly, in older days, people revered rivers, mountains, forests and animals. For example, many villages had a sacred lake, and around it a grove of trees to catch rainfall and protect the banks from erosion. The lake and its grove would store rainfall to irrigate surrounding fields and also to provide drinking water to the local community. In recent times, the neglect of these simple techniques for gathering and protecting clean water has led to serious water shortage crisis. These are just few among many traditions followed by our forefathers. The objective of this paper is to study the traditional techniques of environmental protection that were followed in ancient India and to provide suggestions to government entities, NGO’s and International organizations for embracing those techniques for a sustainable future. It is high time to seek lessons from the spiritual heritage of our country as they offer auniquesetofmoralvaluesandcustomsthat serves as a guide in nurturing the relationship between man and nature, thereby, leading to a sustainable future

Sonographic assessment of fetal head deflexion using occiput: spine angle measured during first stage of labour and its role in predicting the mode of delivery among nulliparous women

Background: The attitude of the fetal head during labour significantly influences the progress and outcome of delivery and is mainly diagnosed by vaginal examination during labour. The aim of the study was to quantify the extent of deflexion of the fetal head by measuring the fetal occiput spine angle (OSA) through transabdominal ultrasonography in the first stage of labour and to determine whether the fetal OSA can predict the mode of delivery.Methods: We conducted a prospective observational study on 145 nulliparous uncomplicated singleton pregnant women without occiput-posterior position of the fetus during active labour. The OSA was measured as the angle between the two tangential lines to the occipital bone and the vertebral body of the first cervical spine, during active labour and monitored until delivery. Intra- and interobserver reproducibility of the OSA measurement and the correlation between the OSA and mode of delivery were also evaluated.Results: For the study population, the mean value of the OSA measured in the active phase of the first stage was 124.2±11.5⁰. The OSA measurement showed excellent intraobserver agreement (r = 0.82; 95% confidence interval [95% CI] 0.70-0.80) and fair-to-good interobserver agreement (r = 0.62; 95% CI 0.51-0.71).  The mean OSA was significantly less for the group of patients who required conversion to cesarean section due to labour arrest (n=32) as compared to those who had vaginal delivery (n=113) (116.25±9.2⁰ versus 126.53±11.1⁰, P<0.01). An OSA of ≥121° was associated with vaginal delivery in 80.5% (91/113) of women, whereas 87.5% (28/32) of the women who delivered by cesarean section had an OSA <121⁰.Conclusions: Measurement of the OSA, by sonography is feasible, reproducible and an objective tool to assess the degree of fetal head deflexion during labour and to predict the mode of delivery

A VALIDATED RP-HPLC METHOD FOR IMPURITY PROFILING OF SODIUM NITROPRUSSIDE IN INJECTION DOSAGE FORM

Objective: The main objective of this research work is to develop and validate a single reverse-phase high-performance liquid chromatography (RP-HPLC) method. This method should becapable of quantifying all the known, as well as other possible degradation impurities of sodium nitroprusside (SNP) in its injection formulation. Methods: Of allmethod development trails, we have observed better separations between known and degradation impuritiesin Inert sustain C18, (250 x 4.6) mm, 5 µm column at 30 °C temperature. Isocratic elution was carried out by using pH 8.6 phosphate buffer and acetonitrile in the ratio of 65:35 %v/v with a flow rate of 0.8 ml/min. The detection was carried out at 220 nm, with an injection volume of 10 µl. Results: In the proposed method, SNP was eluted at 22.5 min. Nitrite, nitrate, and ferrocyanide were linear from 0.25 to 37 μg/ml, ferricyanide was linear from 1.0 to 37 μg/ml, and SNP was linear from 0.75 to 37 μg/ml. The % RSD for six spiked samples (precision)was found to be less than 0.5 %. Accuracy was performed for known impurities from LOQ to 150 % for a 0.5 % specification level. The resultswere found to be in the acceptance range of 90-110 %. The LOQ concentration of nitrite, nitrate, and ferrocyanide was 0.25 μg/ml each,LOQ offerricyanide and SNP was found to be 1.0 μg/ml and 0.75 μg/ml, respectively. The SNP injection samples were exposed to different degradation conditions, and the results were found specific in the proposed methodology. Conclusion: The proposed RP-HPLC method is specific, precise, accurate, linear, stable, and robust for quantification of known and other possible degradation impurities in SNP injection formulation

Implementation of Leaky Bucket with deep learning Algorithm to Avoid Congestion in DEC Protocol in medical applications

A wireless sensor network is a critical component in many disciplines. There are a large number of sensor nodes in it. These sensor nodes perform various tasks, including identifying, dispensing, communicating, and providing power. Data is sent from source to destination and plays an important role. Congestion will occur during data transfer =0&gt;0from one node to another and in the cluster head. Congestion will emerge as a result of either traffic division or resource allocation. Energy will be wasted due to traffic division congestion, which results in packet loss and retransmission of deleted packets. As a result, it must condense. Congestion management will be handled by a few wireless sensor networks using various protocols. Deterministic Energy Efficient Clustering (DEC) protocol is considered to reduce energy consumption based on residual energy in which the leaky bucket algorithm is cast-off. In the event of congestion, our plan outlines a strategy for dealing with and resolving it using this manner. According to simulation testing, the suggested approach may significantly improve longevity, energy, throughput, and packet loss

Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis.

The endothelin axis and in particular the two endothelin receptors, ETA and ETB, are targets for therapeutic intervention in human diseases. Endothelin-receptor antagonists are in clinical use to treat pulmonary arterial hypertension and have been under clinical investigation for the treatment of several other diseases, such as systemic hypertension, cancer, vasospasm, and fibrogenic diseases. In this Perspective, we review the molecules that have been evaluated in human clinical trials for the treatment of pulmonary arterial hypertension, as well as other cardiovascular diseases, cancer, and fibrosis. We will also discuss the therapeutic consequences of receptor selectivity with regard to ETA-selective, ETB-selective, or dual ETA/ETB antagonists. We will also consider which chemical characteristics are relevant to clinical use and the properties of molecules necessary for efficacy in treating diseases against which known molecules displayed suboptimal efficacy

Waste mangement- issues and solutions for a coastal village along Kerala, southwest coast of India

In the present world, plastics play an integral role in human life. Its production crosses 150 million tonnes per year globally and India contributes to more than 8 million tonnes, in terms of consumption. Plastic is cost effective, durable and holds a broad range of application, which turned it to a basic need for the human society. On the other side, 70 % of the consumption is converted as waste and when the infrastructure of the waste management system do not match with the generation rate, it becomes a menace to the society. One of the major concerns of fishermen has been the depleting fishery resources and degrading environment. With an aim to understand the magnitude of marine litter in coastal waters and the way it affects traditional small scale fishers the present study was undertaken. The study area is Mulavukad village Panchayat (latitude 10°02’98.21’’ and longitude 76°25’53.26’’) which is a long narrow stretch of land located in the Ernakulum district of Kerala state, India with an area of 19.27 sq km. The island is surrounded by Periyar river on the North east and Vembanad Lake on the South west. The major lively hood of the people is fishing and fishery related activities

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes.

A considerable body of research indicates that mammary gland branching morphogenesis is dependent, in part, on the extracellular matrix (ECM), ECM-receptors, such as integrins and other ECM receptors, and ECM-degrading enzymes, including matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). There is some evidence that these ECM cues affect one or more of the following processes: cell survival, polarity, proliferation, differentiation, adhesion, and migration. Both three-dimensional culture models and genetic manipulations of the mouse mammary gland have been used to study the signaling pathways that affect these processes. However, the precise mechanisms of ECM-directed mammary morphogenesis are not well understood. Mammary morphogenesis involves epithelial 'invasion' of adipose tissue, a process akin to invasion by breast cancer cells, although the former is a highly regulated developmental process. How these morphogenic pathways are integrated in the normal gland and how they become dysregulated and subverted in the progression of breast cancer also remain largely unanswered questions