Spatiotemporal Chaos, Localized Structures and Synchronization in the Vector Complex Ginzburg-Landau Equation

We study the spatiotemporal dynamics, in one and two spatial dimensions, of two complex fields which are the two components of a vector field satisfying a vector form of the complex Ginzburg-Landau equation. We find synchronization and generalized synchronization of the spatiotemporally chaotic dynamics. The two kinds of synchronization can coexist simultaneously in different regions of the space, and they are mediated by localized structures. A quantitative characterization of the degree of synchronization is given in terms of mutual information measures.Comment: 6 pages, using bifchaos.sty (included). 7 figures. Related material, including higher quality figures, could be found at http://www.imedea.uib.es/PhysDept/publicationsDB/date.html . To appear in International Journal of Bifurcation and Chaos (1999

Roadmap to cure multiple myeloma

Despite significant advances in the treatment of multiple myeloma which had led to unprecedented rates of response and survival, patients still relapse, and cure remains elusive. We propose in this review a roadmap to achieve the dream of cure for multiple myeloma based on five complementary strategies. First, to increase knowledge about disease pathogenesis with a focus on the biology of circulating tumor cells, responsible for dissemination and extramedullary disease, and minimal residual disease clones who represent the reservoir of clonal evolution and disease recurrence. Second, to consider undetectable measurable residual disease (MRD), defined by high-sensitive techniques, as the new endpoint of therapy. Third, to treat disease causation instead of symptomatology through early detection and intervention. Thereby, by treating high-risk smoldering myeloma patients early, we may not only contribute to delay disease progression into active disease but also to increase the cure rates. Fourth, to use the most active scheme in standard-risk patients if the cure is in the horizon. Fifth, to investigate experimental therapies in newly diagnosed patients with high-risk MM, implementing early rescue intervention strategies with the goal of eradicating all tumor clones, and achieving minimal residual disease negativity

New forms of masculinity in Western films: The end of the Marlboro Man?

Westerns are one of the most masculine and stereotypical of film genres. In a social and film context where gender equality is increasingly important, it is worth looking at the evolution of the genre in recent years. Especially because, as André Bazin said, the Western is “cinema par excellence” (1966) and its analysis allows a reflection on cinema itself. Taking the figure of the Marlboro Man as a prototype, this study carries out an analysis of three selected case studies: Brokeback Mountain, Jane Got a Gun and Godless, two films and a miniseries with main characters that do not follow heteronormative masculinity. Ang Lee’s work broke new ground not only in Westerns but also in industrial cinema by making homosexuality visible, while Gavin O’Connor’s showed the possibility of a woman playing the leading role in a classic Western. The miniseries produced by Netflix combines both by giving leading roles to female characters, some of them gay, while reflecting on homosexuality. It was noted that the portrayal of masculinity in Western films remains valid in all three cases, but it allows women and homosexuals to access leading roles, often by acquiring typically masculine attributes

Age-related differences in breast cancer mortality according to race/ethnicity, insurance, and socioeconomic status.

BackgroundWe assessed breast cancer mortality in older versus younger women according to race/ethnicity, neighborhood socioeconomic status (nSES), and health insurance status.MethodsThe study included female breast cancer cases 18 years of age and older, diagnosed between 2005 and 2015 in the California Cancer Registry. Multivariable Cox proportional hazards modeling was used to generate hazard ratios (HR) of breast cancer specific deaths and 95% confidence intervals (CI) for older (60+ years) versus younger (< 60 years) patients separately by race/ethnicity, nSES, and health insurance status.ResultsRisk of dying from breast cancer was higher in older than younger patients after multivariable adjustment, which varied in magnitude by race/ethnicity (P-interaction< 0.0001). Comparing older to younger patients, higher mortality differences were shown for non-Hispanic White (HR = 1.43; 95% CI, 1.36-1.51) and Hispanic women (HR = 1.37; 95% CI, 1.26-1.50) and lower differences for non-Hispanic Blacks (HR = 1.17; 95% CI, 1.04-1.31) and Asians/Pacific Islanders (HR = 1.15; 95% CI, 1.02-1.31). HRs comparing older to younger patients varied by insurance status (P-interaction< 0.0001), with largest mortality differences observed for privately insured women (HR = 1.51; 95% CI, 1.43-1.59) and lowest in Medicaid/military/other public insurance (HR = 1.18; 95% CI, 1.10-1.26). No age differences were shown for uninsured women. HRs comparing older to younger patients were similar across nSES strata.ConclusionOur results provide evidence for the continued disparity in Black-White breast cancer mortality, which is magnified in younger women. Moreover, insurance status continues to play a role in breast cancer mortality, with uninsured women having the highest risk for breast cancer death, regardless of age

Design and manufacture of a customised temporomandibular prosthesis

In this work, design, manufacture and surgical success of a personalised temporomandibular prosthesis is featured. A fused deposition modelling technique and Die forging process constitute the methodology used in a patient who had an amputation in the upper third branch of the mandible, without considering the joint capsule. The implant was designed using a processed resection image of a computational tomography and using the methodology of Özkaya and Nordin. The jaw operating conditions were simulated by the finite element method (FEM). The main considered factors were the morphological geometry of the patient, implant fixation in the first third of the branch, implant fixation on the chin, dental post for placement of the teeth, and the form of the sub-lingual fossa weight optimisation. Special consideration was to preserve the patients facial aesthetics.Peer Reviewe

Lipids metabolites and essential oil from the green alga Chara vulgaris

Les stérols, les acides gras et les huiles essentielles ont été analysés chez l’algue d’eau douce Chara vulgaris. Les stérols majeurs sont le 24-éthylcholest-5-èn-3-ol et l’isofucostérol alors que les principaux acides gras sont le C16:0, le C18:0 et le C18:1. L’huile essentielle obtenue est analysée par CPG-SM. Les produits volatiles contiennent des hydrocarbures, des esters, des aldéhydes et des alcools. Le n-heptadécane, le 7-heptadécène, le phytol, le 6,10,14-triméthylpentadécan-2-one et le méthylundécanoate sont les composés volatiles les plus abondants. Deux terpénoides ont été identifiés, la 5,6-époxy-ß-ionone et la ß- ionone. Les résultats obtenus peuvent être utilisés comme critères chemo-taxonomiques

Relación entre los serotipos de lengua azul y su vector, en Europa y cuenca mediterránea

La Lengua Azul es una enfermedad de distribución mundial que afecta a rumiantes y se transmite a través de la picadura de las hembras del mosquito del Género Culicoides. Tradicionalmente, la enfermedad ha estado ligada a la presencia del mosquito Culicoides imicola, pero estudios recientes apuntan a una posible implicación de otras especies de mosquitos que puedan sobrevivir en regiones más frías. Utilizando un sistema de visualización geográfica ARCGIS 9.2 (ESRI®) se ha podido representar la distribución de las principales especies de Culicoides implicadas en la transmisión de Lengua Azul en Europa y norte de África y compararlo con el mapa de distribución de los serotipos del virus de la Lengua Azul. El análisis de los mapas realizados prueba que Culicoides imicola está relacionado con la transmisión de los serotipos 1, 2, 4, 9 y 16 y que el complejo Obsoletus transmite el serotipo 8 y podría ser capaz de transmitir otros serotipos del virus con los que hasta ahora no ha tenido contacto.Bluetongue (BT) is a worldwide spread disease affecting ruminants, which is transmitted by the biting of female midges from the Genus Culicoides. Traditionally, this disease has been linked with the presence of the midge Culicoides imicola, but, recent studies have suggested the possibility of other midge species being involved in the transmission of Bluetongue in cooler regions. By applying the geographic information system ARCGIS 9.2 (ESRI®), the distribution of the main Culicoides species involved in Blue Tongue transmission in Europe and the North of Africa and the distribution of BT serotypes in the same region has been represented. The analysis of the maps obtained shows that Culicoides imicola is involved in the transmission of Bluetongue serotypes 1, 2, 4, 9 and 16 and the Obsoletus complex could be able to transmit, besides BTV-8, other BT serotypes with which it has never been in contact so far