On the convergence of cosmographic expansions in Lemaître-Tolman-Bondi models

We study cosmographic expansions of the luminosity distance for a variety of Lemaître-Tolman-Bondi (LTB) models which we specify inspired by local large-scale structures of the Universe. We consider cosmographic expansions valid for general spacetimes and compare to the Friedmann-Lemaître- Robertson-Walker (FLRW) limit of the expansions as well as to its naive isotropic extrapolation to an inhomogeneous Universe. The FLRW expansions are often poor near the observer but become better at higher redshifts, where the light rays have reached the FLRW background. In line with this we find that the effective Hubble, deceleration and jerk parameters of the general cosmographic expansion are often very different from the global ΛCDM values, with deviations up to several orders of magnitude. By comparing with the naive isotropic extrapolation of the FLRW expansion, we assess that these large deviations are mainly due to gradients of the shear. Very close to the observer, the general cosmographic expansion is always best and becomes more precise when more expansion terms are included. However, we find that the convergence radius of the general cosmographic expansion is small for all studied models and observers and the general cosmographic expansion becomes poor for most of the studied observers already before a single LTB structure has been traversed. The small radius of convergence of the general cosmographic expansion has also been indicated by earlier work and may need careful attention before we can safely apply the general cosmographic expansion to real data.</p

Overfeeding, Autonomic Regulation and Metabolic Consequences

The autonomic nervous system plays an important role in the regulation of body processes in health and disease. Overfeeding and obesity (a disproportional increase of the fat mass of the body) are often accompanied by alterations in both sympathetic and parasympathetic autonomic functions. The overfeeding-induced changes in autonomic outflow occur with typical symptoms such as adiposity and hyperinsulinemia. There might be a causal relationship between autonomic disturbances and the consequences of overfeeding and obesity. Therefore studies were designed to investigate autonomic functioning in experimentally and genetically hyperphagic rats. Special emphasis was given to the processes that are involved in the regulation of peripheral energy substrate homeostasis. The data revealed that overfeeding is accompanied by increased parasympathetic outflow. Typical indices of vagal activity (such as the cephalic insulin release during food ingestion) were increased in all our rat models for hyperphagia. Overfeeding was also accompanied by increased sympathetic tone, reflected by enhanced baseline plasma norepinephrine (NE) levels in both VMH-lesioned animals and rats rendered obese by hyperalimentation. Plasma levels of NE during exercise were, however, reduced in these two groups of animals. This diminished increase in the exercise-induced NE outflow could be normalized by prior food deprivation. It was concluded from these experiments that overfeeding is associated with increased parasympathetic and sympathetic tone. In models for hyperphagia that display a continuously elevated nutrient intake such as the VMH-lesioned and the overfed rat, this increased sympathetic tone was accompanied by a diminished NE response to exercise. This attenuated outflow of NE was directly related to the size of the fat reserves, indicating that the feedback mechanism from the periphery to the central nervous system is altered in the overfed state.

Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations

Women with mutations of the genes BRCA1 or BRCA2 are at increased risk of ovarian cancer. Oral contraceptives protect against ovarian cancer in general, but it is not known whether they protect against the disease in carriers of these mutations. We obtained self-reported lifetime histories of oral contraceptive use from 451 women who carried mutations of BRCA1 or BRCA2. We used conditional logistic regression to estimate the odds ratios associated with oral contraceptive use, comparing the histories of 147 women with ovarian cancer (cases) to those of 304 women without ovarian cancer (controls) who were matched to cases on year of birth, country of residence and gene (BRCA1 vs BRCA2). Reference ages for controls had to exceed the ages at diagnosis of their matched cases. After adjusting for parity, the odds-ratio for ovarian cancer associated with use of oral contraceptives for at least 1 year was 0.85 (95 percent confidence interval, 0.53-1.36). The risk decreased by 5% (1-9%) with each year of use (P for trend=0.01). Use for 6 or more years was associated with an odds-ratio of 0.62 (0.35-1.09). These data support the hypothesis that long-term oral contraceptive use reduces the risk of ovarian cancer among women who carry mutations of BRCA1 or BRCA2

Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism

<p>Abstract</p> <p>Background</p> <p>The variable penetrance of ovarian cancer in <it>BRCA1 </it>mutation carriers suggests that other genetic or environmental factors modify disease risk. The C to T transition in the 3' untranslated region of the prohibitin (<it>PHB</it>) gene alters mRNA function and has recently been shown to be associated with hereditary breast cancer risk in Polish women harbouring <it>BRCA1 </it>mutations.</p> <p>Methods</p> <p>To investigate whether the <it>PHB </it>3'UTR polymorphism also modifies hereditary ovarian cancer risk, we performed a case-control study among Polish women carrying one of the three common founder mutations (5382insC, 300 T > G, 4154delA) including 127 ovarian cases and 127 unaffected controls who had both breasts and ovaries intact. Controls were matched to cases by year of birth and <it>BRCA1 </it>mutation. Genotyping analysis was performed using PCR-based restriction fragment length polymorphism analysis. Odds ratios (OR) were calculated using conditional and penalized univariable and multivariable logistic regression.</p> <p>Results</p> <p>A comparison of the genotype frequencies between cases and controls revealed no association of the <it>PHB </it>3'UTR _CT+TT genotypes with ovarian cancer risk (OR_adj1.34; 95% CI, 0.59–3.11).</p> <p>Conclusion</p> <p>Our data suggest that the <it>PHB </it>3'UTR polymorphism does not modify ovarian cancer risk in women carrying one of the three Polish <it>BRCA1 </it>founder mutations.</p

Características sócio-econômicas de pacientes com acidente vascular cerebral

Estudo de aspectos sócio-econômicos de 206 pacientes com AVC, atendidos no ambulatório de Doenças Neurovasculares no período de 1991 a 1992. Os principais achados foram: 23% dos pacientes apresentavam idade inferior a SO anos; o estado civil casado era significantemente mais frequente nos homens; 82% dos pacientes eram analfabetos ou semianalfabetos e 60% vivem com renda familiar de 1 a 2 salários mínimos. O impacto sócio-econômico causado pela instalação de um AVC em um membro da família é sempre grande. O baixo índice de educação e a baixa renda são os principais fatores que contribuem para o mau controle da doença, influenciando diretamente na compreensão a respeito da importância do tratamento e prevenção. Ressaltamos a importância da atuação do Serviço Social para detectar e orientar a solução de problemas na esfera sócio-econômica para obtenção de melhor controle médico.We studied the socioeconomic status of 206 stroke patients seen at Escola Paulista de Medicina - São Paulo in the period 1991-1992. We found that 25% of patients were less than 50 years old; men were married significantly more often than women; 82% of patients had less than 8 years of formal education and 60% of the families survived with US$ 98 to 198. The socioeconomic impact caused by stroke is very important. Low education and poverty influence the treatment and prevention of the disease. The Social Assistance Service can detect and attempt to solve the social problems in order to obtain a better control of systemic diseases and risk factors for stroke, and to give orientation concerning the local resources