Are you getting sick? Predicting influenza-like symptoms using human mobility behaviors

Understanding and modeling the mobility of individuals is of paramount importance for public health. In particular, mobility characterization is key to predict the spatial and temporal diffusion of human-transmitted infections. However, the mobility behavior of a person can also reveal relevant information about her/his health conditions. In this paper, we study the impact of people mobility behaviors for predicting the future presence of flu-like and cold symptoms (i.e. fever, sore throat, cough, shortness of breath, headache, muscle pain, malaise, and cold). To this end, we use the mobility traces from mobile phones and the daily self-reported flu-like and cold symptoms of 29 individuals from February 20, 2013 to March 21, 2013. First of all, we demonstrate that daily symptoms of an individual can be predicted by using his/her mobility trace characteristics (e.g. total displacement, radius of gyration, number of unique visited places, etc.). Then, we present and validate models that are able to successfully predict the future presence of symptoms by analyzing the mobility patterns of our individuals. The proposed methodology could have a societal impact opening the way to customized mobile phone applications, which may detect and suggest to the user specific actions in order to prevent disease spreading and minimize the risk of contagion

Parametric Generation of Second Sound by First Sound in Superfluid Helium

We report the first experimental observation of parametric generation of second sound (SS) by first sound (FS) in superfluid helium in a narrow temperature range in the vicinity of $T_\lambda$. The temperature dependence of the threshold FS amplitude is found to be in a good quantitative agreement with the theory suggested long time ago and corrected for a finite geometry. Strong amplitude fluctuations and two types of the SS spectra are observed above the bifurcation. The latter effect is quantitatively explained by the discreteness of the wave vector space and the strong temperature dependence of the SS dissipation length.Comment: 4 pages, 4 postscript figures, REVTE

Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism

Exposure of rats to elevated dietary salt following recovery from acute kidney injury (AKI) accelerates the transition to chronic kidney disease (CKD), and is dependent on lymphocyte activity. Here we tested whether high salt diet triggers lymphocyte activation in postischemic kidneys to worsen renal inflammation and fibrosis. Male Sprague-Dawley rats on a 0.4% salt diet were subjected to left unilateral ischemia-reperfusion and allowed to recover for 5 weeks. This resulted in a mild elevation of CD4(+) T cells relative to sham animals. Contralateral unilateral nephrectomy and elevated dietary salt (4%) for 4 extra weeks hastened CKD and interstitial fibrosis. Activated T cells were increased in the kidney threefold after 4 weeks of elevated dietary salt exposure relative to post-AKI rats before salt feeding. The T cell subset was largely positive for IL-17, indicative of Th-17 cells. Because angiotensin II activity may influence lymphocyte activation, injured rats were given the AT1R antagonist, losartan, along with high salt diet. This significantly reduced the number of renal Th-17 cells to levels of sham rats, and significantly reduced the salt-induced increase in fibrosis to about half. In vitro studies in AKI-primed CD4(+) T cells indicated that angiotensin II and extracellular sodium enhanced, and losartan inhibited, IL-17 expression. Thus, dietary salt modulates immune cell activity in postischemic recovering kidneys because of the activity of local RAS, suggesting the participation of these cells in CKD progression post-AKI

Segue Between Favorable and Unfavorable Solvation

Solvation of small and large clusters are studied by simulation, considering a range of solvent-solute attractive energy strengths. Over a wide range of conditions, both for solvation in the Lennard-Jones liquid and in the SPC model of water, it is shown that the mean solvent density varies linearly with changes in solvent-solute adhesion or attractive energy strength. This behavior is understood from the perspective of Weeks' theory of solvation [Ann. Rev. Phys. Chem. 2002, 53, 533] and supports theories based upon that perspective.Comment: 8 pages, 7 figure

Fast Algorithms For Josephson Junction Arrays : Bus--bars and Defects

We critically review the fast algorithms for the numerical study of two--dimensional Josephson junction arrays and develop the analogy of such systems with electrostatics. We extend these procedures to arrays with bus--bars and defects in the form of missing bonds. The role of boundaries and of the guage choice in determing the Green's function of the system is clarified. The extension of the Green's function approach to other situations is also discussed.Comment: Uuencoded 1 Revtex file (11 Pages), 3 Figures : Postscript Uuencode

Bronchoalveolar lavage study in victims of toxic gas leak at Bhopal

Bronchoalveolar lavage using flexible fibreoptic bronchoscope was carried out in 50 patients 1-2½ yr after exposure to the ‘toxic gas’ at Bhopal. Thirty six patients in the analysis were categorised into 3 groups (viz., mild, moderate and severe), depending upon the severity of exposure. There was an increase in cellularity in the lower respiratory tract (alveolitis) of the severely exposed patients (in both smokers and non-smokers), compared to normals (P< 0.05). The increase in cellularity in severely exposed non-smokers was due to abnormal accumulation of macrophages (P<0.01), and in severely exposed smokers, to macrophages (P<0.01) and neutrophils (P<0.05). Mild and moderately exposed patients did not show significant change in cellularity in lower respiratory tract, compared to normal individuals (P>0.2). There was a trend towards increasing cellularity, as the severity increased (P < 0.0001) and higher numbers of total cells were seen in severely exposed smokers, suggesting that smoking is a risk factor. It appears, therefore, that subjects severely exposed to the toxic gas at Bhopal may have a subclinical alveolitis characterised by accumulation and possibly activation of macrophages in the lower respiratory tract. Smokers, who were exposed to the gas had in addition, accumulation of neutrophils

Low-Temperature Mobility of Surface Electrons and Ripplon-Phonon Interaction in Liquid Helium

The low-temperature dc mobility of the two-dimensional electron system localized above the surface of superfluid helium is determined by the slowest stage of the longitudinal momentum transfer to the bulk liquid, namely, by the interaction of surface and volume excitations of liquid helium, which rapidly decreases with temperature. Thus, the temperature dependence of the low-frequency mobility is \mu_{dc} = 8.4x10^{-11}n_e T^{-20/3} cm^4 K^{20/3}/(V s), where n_e is the surface electron density. The relation T^{20/3}E_\perp^{-3} << 2x10^{-7} between the pressing electric field (in kV/cm) and temperature (in K) and the value \omega < 10^8 T^5 K^{-5}s^{-1} of the driving-field frequency have been obtained, at which the above effect can be observed. In particular, E_\perp = 1 kV/cm corresponds to T < 70 mK and \omega/2\pi < 30 Hz.Comment: 4 pages, 1 figur