13 research outputs found

    Parmenides: an opportunity for ISO TC37 SC4?

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    Despite the many initiatives in recent years aimed at creating Language Engineering standards, it is often the case that different projects use different approaches and often define their own standards. Even within the same project it often happens that different tools will require different ways to represent their linguistic data. In a recently started EU project focusing on the integration of Information Extraction and Data Mining techniques, we aim at avoiding the problem of incompatibility among different tools by defining a Common Annotation Scheme internal to the project. However, when the project was started (Sep 2002) we were unaware of the standardization effort of ISO TC37/SC4, and so we commenced once again trying to define our own schema. Fortunately, as this work is still at an early stage (the project will last till 2005) it is still possible to redirect it in a way that it will be compatible with the standardization work of ISO. In this paper we describe the status of the work in the project and explore possible synergies with the work in ISO TC37 SC4

    Brain function in the vegetative state.

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    Positron emission tomography (PET) techniques represent a useful tool to better understand the residual brain function in vegetative state patients. It has been shown that overall cerebral metabolic rates for glucose are massively reduced in this condition. However, the recovery of consciousness from vegetative state is not always associated with substantial changes in global metabolism. This finding led us to hypothesize that some vegetative patients are unconscious not just because of a global loss of neuronal function, but rather due to an altered activity in some critical brain regions and to the abolished functional connections between them. We used voxel-based Statistical Parametric Mapping (SPM) approaches to characterize the functional neuroanatomy of the vegetative state. The most dysfunctional brain regions were bilateral frontal and parieto-temporal associative cortices. Despite the metabolic impairment, external stimulation still induced a significant neuronal activation (i.e. change in blood flow) in vegetative patients as shown by both auditory click stimuli and noxious somatosensory stimuli. However, this activation was limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception. Finally, we demonstrated that vegetative patients have impaired functional connections between distant cortical areas and between the thalami and the cortex and, more importantly, that recovery of consciousness is paralleled by a restoration of this cortico-thalamo-cortical interaction.Journal ArticleResearch Support, Non-U.S. Gov'tReviewinfo:eu-repo/semantics/publishe

    Zerebrale Funktionen bei hirngeschädigten Patienten. Was bedeuten Koma,

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    Comatose, vegetative, minimally conscious or locked-in patients represent a problem in terms of diagnosis, prognosis, treatment and everyday management at the intensive care unit. The evaluation of possible cognitive functions in these patients is difficult because voluntary movements may be very small, inconsistent and easily exhausted. Functional neuroimaging cannot replace the clinical assessment of patients with altered states of consciousness. Nevertheless, it can describe objectively how deviant from normal the cerebral activity is and its regional distribution at rest and under various conditions of stimulation. The quantification of brain activity differentiates patients who sometimes only differ by a brief and incomplete blink of an eye. In the present paper, we will first try to define consciousness as it can be assessed at the patient's bedside. We then review the major clinical entities of altered states of consciousness encountered in the intensive care unit. Finally, we discuss the functional neuroanatomy of these conditions as assessed by positron emission tomography (PET) scanning.English AbstractJournal ArticleReviewinfo:eu-repo/semantics/publishe
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