Gender Differences in the Relational and Collective Bases for Trust

A variety of research suggests that men and women differ in their interdependent orientation: whereas women tend to be more relationally interdependent, men tend to be more collectively interdependent (e.g. Gabriel & Gardner, 1999). The current study sought to investigate differences in interdependence within the domain of trust. In particular, the authors predicted that men would tend to trust individuals based on whether or not they shared group memberships. On the other hand, women were predicted to trust those who shared direct or indirect relationship connections. Results from an online trust-dilemma game supported these predictions. Implications for our understanding of the impact of gender on social identity and self-representation are discussed

Transit Mobility and Premature Birth in New York City: a Population-Based Study

Transit mobility has been recognized as an essential element to economic attainment, environmental sustainability, and as a vital part of public health⁠. Social and economic disparities paired with elusive and inefficient public transit present real barriers for the ability of efficient planning and use of time⁠. Lengthier commutes and generally less efficient travel contribute to stress during a pregnancy and limit the ability to access work and prenatal care. In survey studies of women utilizing clinics as their prenatal care provider, nearly 25% listed transportation as a barrier to accessing care. Prior research has not linked directly premature birth and low birthweight and contributing factors of stress, work, and prenatal care into discussions of spatial mismatch to availability of efficient transit. This research proposes that transit mobility likely impacts premature birth and low birthweight through two pathways: actively, through increasing the likelihood of infection and stress both of which promote uterine inflammation, and through impacting prevention, by limiting access to timely and adequate prenatal care. In dense urban environments, transit planning must begin to address the challenges transit may present to pregnant women specifically, and especially in most at-risk communities. Suggested is free, comprehensive para-transport to attend prenatal care visits, such as have been highly successful programs for servicing urban handicapped communities when implemented effectively. As well, if pregnancy tests were omnipresent and free similar to the flu shot, in combination with transportation assistance, rates of timely initiation of prenatal care could be improved. These measures, however can only be viewed as incremental improvements to materially address an issue which has much deeper cultural causes which must be addressed to make profound impacts, such as are rooted in cultural and structural misogyny

Large-eddy simulation of two-dimensional dunes in a steady, unidirectional flow

We performed large-eddy simulations of the flow over a typical two-dimensional dune geometry at laboratory scale (the Reynolds number based on the average channel height andmean velocity is 18,900) using the Lagrangian dynamic eddy-viscosity subgrid-scale model. The results are validated by comparison with simulations and experiments in the literature. The flowseparates at the dune crest, generating a shear layer that plays a crucial role in the transport of momentum and energy, and the generation of coherent structures. The turbulent kinetic energy budgets show the importance of the turbulent transport and mean-flow advection in the bulk flow above the shear layer. In the recirculation zone and in the attached boundary layers production and dissipation are the most important terms. Large, coherent structures of various types can be observed. Spanwise vortices are generated in the separated shear layer due to the Kelvin-Helmholtz instability; as they are advected, they undergo lateral instabilities and develop into horseshoe-like structures, are tilted downward, and finally reach the surface. The ejection that occurs between the legs of the vortex creates the upwelling and downdrafting events on the free surface known as "boils." Near-wall turbulence, after the reattachment point, is affected by large streamwise Taylor-Görtler vortices generated on the concave part of the stoss side, which affect the distribution of the near-wall streaks

Multidimensional Methods for the Formulation of Bipharmaceuticals and Vaccines

Determining and preserving the higher order structural integrity and conformational stability of proteins, plasmid DNA and macromolecular complexes such as viruses, virus-like particles and adjuvanted antigens is often a significant barrier to the successful stabilization and formulation of biopharmaceutical drugs and vaccines. These properties typically must be investigated with multiple lower resolution experimental methods, since each technique monitors only a narrow aspect of the overall conformational state of a macromolecular system. This review describes the use of empirical phase diagrams (EPDs) to combine large amounts of data from multiple high-throughput instruments and construct a map of a target macromolecule's physical state as a function of temperature, solvent conditions, and other stress variables. We present a tutorial on the mathematical methodology, an overview of some of the experimental methods typically used, and examples of some of the previous major formulation applications. We also explore novel applications of EPDs including potential new mathematical approaches as well as possible new biopharmaceutical applications such as analytical comparability, chemical stability, and protein dynamics

An Improved Methodology for Multidimensional High- Throughput Preformulation Characterization of Protein Conformational Stability

The Empirical Phase Diagram (EPD) technique is a vector-based multidimensional analysis method for summarizing large data sets from a variety of biophysical techniques. It can be used to provide comprehensive preformulation characterization of a macromolecule’s higher-order structural integrity and conformational stability. In its most common mode, it represents a type of stimulus-response diagram using environmental variables such as temperature, pH, and ionic strength as the stimulus, with alterations in macromolecular structure being the response. Until now EPD analysis has not been available in a high throughput mode because of the large number of experimental techniques and environmental stressor/stabilizer variables typically employed. A new instrument has been developed that combines circular dichroism, UV-absorbance, fluorescence spectroscopy and light scattering in a single unit with a 6-position temperature controlled cuvette turret. Using this multifunctional instrument and a new software system we have generated EPDs for four model proteins. Results confirm the reproducibility of the apparent phase boundaries and protein behavior within the boundaries. This new approach permits two EPDs to be generated per day using only 0.5 mg of protein per EPD. Thus, the new methodology generates reproducible EPDs in high-throughput mode, and represents the next step in making such determinations more routine

Does Incident Solar Ultraviolet Radiation Lower Blood Pressure?

Background Hypertension remains a leading global cause for premature death and disease. Most treatment guidelines emphasize the importance of risk factors, but not all are known, modifiable, or easily avoided. Population blood pressure correlates with latitude and is lower in summer than winter. Seasonal variations in sunlight exposure account for these differences, with temperature believed to be the main contributor. Recent research indicates that UV light enhances nitric oxide availability by mobilizing storage forms in the skin, suggesting incident solar UV radiation may lower blood pressure. We tested this hypothesis by exploring the association between environmental UV exposure and systolic blood pressure (SBP) in a large cohort of chronic hemodialysis patients in whom SBP is determined regularly. Methods and Results We studied 342 457 patients (36% black, 64% white) at 2178 US dialysis centers over 3 years. Incident UV radiation and temperature data for each clinic location were retrieved from the National Oceanic and Atmospheric Administration database. Linear mixed effects models with adjustment for ambient temperature, sex/age, body mass index, serum Na+/K+ and other covariates were fitted to each location and combined estimates of associations calculated using the DerSimonian and Laird procedure. Pre-dialysis SBP varied by season and was ≈4 mm Hg higher in black patients. Temperature, UVA and UVB were all linearly and inversely associated with SBP. This relationship remained statistically significant after correcting for temperature. Conclusions In hemodialysis patients, in addition to environmental temperature, incident solar UV radiation is associated with lower SBP. This raises the possibility that insufficient sunlight is a new risk factor for hypertension, perhaps even in the general population.</p

Large-eddy simulation of turbulent open-channel flow over three-dimensional dunes

A large-eddy simulation study has been undertaken to investigate the turbulent structure of open-channel flow over three-dimensional (3D) dunes. The governing equations have been discretized using the finite volume method, with the partial cell treatment being implemented in a Cartesian grid form to deal with the 3D dune topography. The simulated free surface elevations, mean flow velocities and Reynolds shear stress distributions have been compared with experimental measurements published in the literature. Relatively close agreement has been obtained between the two sets of results. The predicted mean velocity field and the associated turbulence structure are significantly different from those observed for flows over two-dimensional dunes. The effects of dune three-dimensionality are reflected in spanwise variations of mean flow fields, secondary currents and different distributions of vertical profiles of the double-averaged velocity. Furthermore, large-scale vortical structures, such as spanwise rollers and hairpin-like structures, are predicted in the simulations, with most of them being generated in the concave regions of the 3D dunes

Haplotype Structure of the ENPP1 Gene and Nominal Association of the K121Q Missense Single Nucleotide Polymorphism With Glycemic Traits in the Framingham Heart Study

OBJECTIVE—A recent meta-analysis demonstrated a nominal association of the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) K→Q missense single nucleotide polymorphism (SNP) at position 121 with type 2 diabetes. We set out to confirm the association of ENPP1 K121Q with hyperglycemia, expand this association to insulin resistance traits, and determine whether the association stems from K121Q or another variant in linkage disequilibrium with it

The intention-behaviour gap: An empirical examination of an integrative perspective to explain exercise behaviour

This study tested the Theory of Planned Behavior (TPB) in conjunction with two sets of variables from the Health Action Process Approach (HAPA) and the Subjective Exercise Experience Scale (SEE) to predict exercise behavior. This study included 454 participants who exercised in a fitness center. We collected measures of the TPB (attitudes, subjective norms, perceived behavioral control, and intention), HAPA (planning), and SEE (positive well-being, psychological distress, and fatigue) and assessed exercise behavior at a three-month follow-up. Structural equation modeling found partial support for the TPB model (explaining 10% of the variance in exercise behavior) and adequate fit indices for an adjusted model of the TPB that includes a positive well-being dimension (explaining 11% of the variance in exercise behavior). In sum, the original TPB partially predicts exercise behavior; when considered together with other predictors, limited evidence was found for its utility in explaining exercise behavior.This study was conducted at Psychology Research Centre (UID/PSI/01662/2013), University of Minho, and supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653).info:eu-repo/semantics/submittedVersio