294 research outputs found

    Phase-sensitive evidence for dx2-y2-pairing symmetry in the parent-structure high-Tc cuprate superconductor Sr1-xLaxCuO2

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    Even after 25 years of research the pairing mechanism and - at least for electron doped compounds - also the order parameter symmetry of the high transition temperature (high-Tc) cuprate superconductors is still under debate. One of the reasons is the complex crystal structure of most of these materials. An exception are the infinite layer (IL) compounds consisting essentially of CuO2 planes. Unfortunately, these materials are difficult to grow and, thus, there are only few experimental investigations. Recently, we succeeded in depositing high quality films of the electron doped IL compound Sr1-xLaxCuO2 (SLCO), with x approximately 0.15, and on the fabrication of well-defined grain boundary Josephson junctions (GBJs) based on such SLCO films. Here we report on a phase sensitive study of the superconducting order parameter based on GBJ SQUIDs from a SLCO film grown on a tetracrystal substrate. Our results show that also the parent structure of the high-Tc cuprates has dx2-y2-wave symmetry, which thus seems to be inherent to cuprate superconductivity.Comment: Submitted to PRL, 5 pages, 3 figures, supplementary information included (4 pages, 4 figures

    Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour

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    We report the case of a 79-year-old male with previous history of non-Hodgkin's lymphoma in remission, who presented acutely to the Accident and Emergency department with recurrent episodes of hypoglycaemia. At the time of presentation, a random glucose was low at 1.4 mmol/l, which upon correction resolved his symptoms. In hindsight, the patient recalled having had similar episodes periodically over the past 2 months to which he did not give much notice. While hospitalized, he continued having episodes of symptomatic hypoglycaemia, requiring treatment with intravenous dextrose and per os steroids. Once stable, he was discharged on oral prednisolone and dietary advice. A computed tomography scan performed during inpatient stay showed multiple deposits in the abdomen. An ultrasound guided biopsy of one of the liver deposits was performed. Immunohistochemistry supported the diagnosis of a gastrointestinal stromal tumour (GIST) positive for CD34 and CD117. The diagnosis of non-islet cell tumour hypoglycaemia (NICTH) secondary to an IGF2 secreting GIST was confirmed with further biochemical investigations (IGF2=105.9 nmol/l; IGF2:IGF1 ratio 23, Upper Level of Normal (ULN) <10). Targeted cytoreductive treatment with Imatinib mesylate following assessment of the tumour's mutational status was successful in preventing hypoglycaemia over a 21-month follow-up observation period

    Laparoscopic adjustable gastric banding – should a second chance be given?

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    Background: Obesity is a chronic relapsing-remitting disease and a global pandemic, being associated with multiple comorbidities. Laparoscopic adjustable gastric banding (LAGB) is one of the safest surgical procedures used for the treatment of obesity, and even though its popularity has been decreasing over time, it still remains an option for a certain group of patients, producing considerable weight loss and improvement in obesity-associated comorbidities. Methods: The aim of this study was to evaluate the impact of weight loss following LAGB on obesity-associated comorbidities, and to identify factors that could predict better response to surgery, and patient sub-groups exhibiting greatest benefit. A total of 99 severely obese patients (81.2% women, mean age 44.19 ± 10.94 years, mean body mass index (BMI) 51.84 ± 8.77 kg/m2) underwent LAGB in a single institution. Results obtained 1, 2, and 5 years postoperatively were compared with the pre-operative values using SPPS software version 20. Results: A significant drop in BMI was recorded throughout the follow-up period, as well as in A1c and triglycerides, with greatest improvement seen 2 years after surgery (51.8 ± 8.7 kg/m2 vs 42.3 ± 9.2 kg/m2, p < 0.05, 55.5 ± 19.1 mmol/mol vs 45.8 ± 13.7 mmol/mol, p < 0.05, and 2.2 ± 1.7 mmol/l vs 1.5 ± 0.6 mmol/l). Better outcomes were seen in younger patients, with lower duration of diabetes before surgery, and lower pre-operative systolic blood pressure. Conclusions: Younger age, lower degree of obesity, and lower severity of comorbidities at the time of surgery can be important predictors of successful weight loss, making this group of patients the ideal candidates for LAGB

    Properties of the electron-doped infinite-layer superconductor Sr1x_{1-x}Lax_{x}CuO2_{2} epitaxially grown by pulsed laser deposition

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    Thin films of the electron-doped infinite-layer cuprate superconductor Sr1x_{1-x}Lax_xCuO2_2 (SLCO) with doping x0.15x \approx 0.15 were grown by means of pulsed laser deposition. (001)-oriented KTaO3_3 and SrTiO3_3 single crystals were used as substrates. In case of SrTiO3_3, a BaTiO3_3 thin film was deposited prior to SLCO, acting as buffer layer providing tensile strain to the SLCO film. To induce superconductivity, the as-grown films were annealed under reducing conditions, which will be described in detail. The films were characterized by reflection high-energy electron diffraction, atomic force microscopy, x-ray diffraction, Rutherford backscattering spectroscopy, and electric transport measurements at temperatures down to T=4.2T = 4.2\,K. We discuss in detail the influence of different process parameters on the final film properties.Comment: 16 pages, 14 figure

    Male obesity associated gonadal dysfunction and the role of bariatric surgery

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    Obesity is an ever growing pandemic and a prevalent problem among men of reproductive age that can both cause and exacerbate male-factor infertility by means of endocrine abnormalities, associated comorbidities, and direct effects on the precision and throughput of spermatogenesis. Robust epidemiologic, clinical, genetic, epigenetic, and preclinical data support these findings. Clinical studies on the impact of medically induced weight loss on serum testosterone concentrations and spermatogenesis is promising but may show differential and unsustainable results. In contrast, literature has demonstrated that weight loss after bariatric surgery is correlated with an increase in serum testosterone concentrations that is superior than that obtained with only lifestyle modifications, supporting a further metabolic benefit from surgery that may be specific to the male reproductive system. The data on sperm and semen parameters is controversial to date. Emerging evidence in the burgeoning field of genetics and epigenetics has demonstrated that paternal obesity can affect offspring metabolic and reproductive phenotypes by means of epigenetic reprogramming of spermatogonial stem cells. Understanding the impact of this reprogramming is critical to a comprehensive view of the impact of obesity on subsequent generations. Furthermore, conveying the potential impact of these lifestyle changes on future progeny can serve as a powerful tool for obese men to modify their behavior. Healthcare professionals treating male infertility and obesity need to adapt their practice to assimilate these new findings to better counsel men about the importance of paternal preconception health and the impact of novel non-medical therapeutic interventions. Herein, we summarize the pathophysiology of obesity on the male reproductive system and emerging evidence regarding the potential role of bariatric surgery as treatment of male obesity-associated gonadal dysfunction

    Entrepreneurial sons, patriarchy and the Colonels' experiment in Thessaly, rural Greece

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    Existing studies within the field of institutional entrepreneurship explore how entrepreneurs influence change in economic institutions. This paper turns the attention of scholarly inquiry on the antecedents of deinstitutionalization and more specifically, the influence of entrepreneurship in shaping social institutions such as patriarchy. The paper draws from the findings of ethnographic work in two Greek lowland village communities during the military Dictatorship (1967–1974). Paradoxically this era associated with the spread of mechanization, cheap credit, revaluation of labour and clear means-ends relations, signalled entrepreneurial sons’ individuated dissent and activism who were now able to question the Patriarch’s authority, recognize opportunities and act as unintentional agents of deinstitutionalization. A ‘different’ model of institutional change is presented here, where politics intersects with entrepreneurs, in changing social institutions. This model discusses the external drivers of institutional atrophy and how handling dissensus (and its varieties over historical time) is instrumental in enabling institutional entrepreneurship

    Do monkeys use sex toys? Evidence of stone tool-assisted masturbation in free-ranging long-tailed macaques

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    Accepted author manuscriptRecent reports on tool use in nonforaging contexts have led researchers to reconsider the proximate drivers of instrumental object manipulation. In this study, we explore the physiological and behavioral correlates of two stone-directed and seemingly playful actions, the repetitive tapping and rubbing of stones onto the genital and inguinal area, respectively, that may have been co-opted into self-directed tool-assisted masturbation in long-tailed macaques (i.e., “Sex Toy” hypothesis). We predicted that genital and inguinal stone-tapping and rubbing would be more closely temporally associated with physiological responses (e.g., estrus in females, penile erection in males) and behavior patterns (e.g., sexual mounts and other mating interactions) that are sexually motivated than other stone-directed play. We also predicted that the stones selected to perform genital and inguinal stone-tapping and rubbing actions would be less variable in number, size, and texture than the stones typically used during other stone-directed playful actions. Overall, our data partly supported the “Sex Toy” hypothesis indicating that stone-directed tapping and rubbing onto the genital and inguinal area are sexually motivated behaviors. Our research suggests that instrumental behaviors of questionably adaptive value may be maintained over evolutionary time through pleasurable/self-rewarding mechanisms, such as those underlying playful and sexual activities

    Italia, Europa e nuove immigrazioni

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    Il volume esamina il problema generale dell’insediamento delle minoranze extraeuropee nei paesi comunitari, ricostruendone la genesi storica. Vengono anche discusse le politiche di inserimento di paesi europei - come la Gran Bretagna, la Francia, la Repubblica federale tedesca e la Svezia - con alti flussi in entrata.- Indice #7- Prefazione #11- Prima parte Introduzione al fenomeno delle migrazioni internazionali in Europa #13- Nodi conflittuali conseguenti all’insediamento definitivo delle popolazioni immigrate nei paesi europei, Albert Bastenier e Felice Dassetto #15- Seconda parte Le politiche nazionali dell’immigrazione #77- L’atteggiamento verso gli immigrati in Gran Bretagna, John Rex #79- Il caso francese, Catherine Wihtol de Wenden #99- La politica verso gli stranieri. Il dibattito per una legge degli anni Novanta sugli stranieri nella Repubblica federale tedesca, Ursula Mehrländer #117- La situazione svedese. Politica sull’immigrazione e sui rifugiati, politica di integrazione e di organizzazione etnica, Carl-Ulrik Schierup #137- Terza parte Problematiche emergenti dall’attuale processo immigratorio in Europa #173- I rifugiati in Europa, Danièle Joly #175- L’emergenza delle politiche di integrazione per gli immigrati in Europa, Han B. Entzinger #191- Nazionalità e cittadinanza nell’Europa delle immigrazioni, Jean Leca #21

    Cumulative culture in nonhumans : overlooked findings from Japanese monkeys?

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    The authors thank Corpus Christi College (Cambridge) for funding DS’s visit to Koshima and Prof. Tetsuro Matsuzawa for funding WCM’s visit to Koshima.Cumulative culture, generally known as the increasing complexity or efficiency of cultural behaviors additively transmitted over successive generations, has been emphasized as a hallmark of human evolution. Recently, reviews of candidates for cumulative culture in nonhuman species have claimed that only humans have cumulative culture. Here, we aim to scrutinize this claim, using current criteria for cumulative culture to re-evaluate overlooked qualitative but longitudinal data from a nonhuman primate, the Japanese monkey (Macaca fuscata). We review over 60 years of Japanese ethnography of Koshima monkeys, which indicate that food-washing behaviors (e.g., of sweet potato tubers and wheat grains) seem to have increased in complexity and efficiency over time. Our reassessment of the Koshima ethnography is preliminary and nonquantitative, but it raises the possibility that cumulative culture, at least in a simple form, occurs spontaneously and adaptively in other primates and nonhumans in nature.Publisher PDFPeer reviewe
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