A calcium ion in a cavity as a controlled single-photon source

We present a single calcium ion, coupled to a high-finesse cavity, as an almost ideal system for the controlled generation of single photons. Photons from a pump beam are Raman-scattered by the ion into the cavity mode, which subsequently emits the photon into a well-defined output channel. In contrast with comparable atomic systems, the ion is localized at a fixed position in the cavity mode for indefinite times, enabling truly continuous operation of the device. We have performed numeric calculations to assess the performance of the system and present the first experimental indication of single-photon emission in our set-up

Ranking ligand affinity for the DNA minor groove by experiment and simulation

The structural and thermodynamic basis for the strength and selectivity of the interactions of minor-groove binders (MGBs) with DNA is not fully understood. In 2003 we reported the first example of a thiazole containing MGB that bound in a phase shifted pattern that spanned 6 base-pairs rather than the usual 4 (for tricyclic distamycin-like compounds). Since then, using DNA footprinting, nuclear magnetic resonance spectroscopy, isothermal titration calorimetry and molecular dynamics, we have established that the flanking bases around the central 4 being read by the ligand have subtle effects on recognition. We have investigated the effect of these flanking sequences on binding and the reasons for the differences and established a computational method to rank ligand affinity against varying DNA sequences

Microwave Assisted Synthesis of Py-Im Polyamides

Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5′-WGWWCW-3′ (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several additional coupling steps

Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA

A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide. While unpaired oligomers of 2,4-disubstituted furan amino acids show poor DNA-binding activity, furan (Fn) carboxamides paired with N-methylpyrrole (Py) and N-methylimidazole (Im) rings demonstrate excellent stabilization of duplex DNA as well as discrimination of noncognate sequences, consistent with function as a Py mimic according to the Py/Im polyamide pairing rules

Wearable Haptic Devices for Gait Re-education by Rhythmic Haptic Cueing

This research explores the development and evaluation of wearable haptic devices for gait sensing and rhythmic haptic cueing in the context of gait re-education for people with neurological and neurodegenerative conditions. Many people with long-term neurological and neurodegenerative conditions such as Stroke, Brain Injury, Multiple Sclerosis or Parkinson’s disease suffer from impaired walking gait pattern. Gait improvement can lead to better fluidity in walking, improved health outcomes, greater independence, and enhanced quality of life. Existing lab-based studies with wearable devices have shown that rhythmic haptic cueing can cause immediate improvements to gait features such as temporal symmetry, stride length, and walking speed. However, current wearable systems are unsuitable for self-managed use for in-the-wild applications with people having such conditions. This work aims to investigate the research question of how wearable haptic devices can help in long-term gait re-education using rhythmic haptic cueing. A longitudinal pilot study has been conducted with a brain trauma survivor, providing rhythmic haptic cueing using a wearable haptic device as a therapeutic intervention for a two-week period. Preliminary results comparing pre and post-intervention gait measurements have shown improvements in walking speed, temporal asymmetry, and stride length. The pilot study has raised an array of issues that require further study. This work aims to develop and evaluate prototype systems through an iterative design process to make possible the self-managed use of such devices in-the-wild. These systems will directly provide therapeutic intervention for gait re-education, offer enhanced information for therapists, remotely monitor dosage adherence and inform treatment and prognoses over the long-term. This research will evaluate the use of technology from the perspective of multiple stakeholders, including clinicians, carers and patients. This work has the potential to impact clinical practice nationwide and worldwide in neuro-physiotherapy

Improving the performance of bright quantum dot single photon sources using amplitude modulation

Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit non-ideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a bright source consisting of a single quantum dot in a fiber-coupled microdisk cavity, we use synchronized amplitude modulation to temporally filter the emitted light. We observe that the single photon purity, temporal overlap between successive emission events, and indistinguishability can be greatly improved with this technique. As this method can be applied to any triggered single photon source, independent of geometry and after device fabrication, it is a flexible approach to improve the performance of solid-state systems, which often suffer from excess dephasing and multi-photon background emission

Smart mobility: a mobile approach

The Internet of Things (IoT) is one of the key ingredients for the realization of Smart Cities. IoT devices are essential components of the Smart Cities infrastructure, as they can provide information collected from the environment through sensors or allow other systems to reach out and act on the world through actuators. IoT data collection, however, is not limited to sensors and machines, but to data from social networks, and the web. Social networks have a huge impact on the amount of data being produced daily, becoming an increasingly central and important data source. The exploitation of these data sources, combined with the growing popularity of mobile devices, can lead to the development of better solutions to improve people’s quality of life. This paper discusses how to take advantage of the benefits of mobile devices and the vast range of information sources and services, such as traffic conditions, and narrow, closed or conditioned roads data. The proposed system uses a real-time collection, organization, and transmission of traffic and road conditions data to provide efficient and accurate information to drivers. With the purpose of supporting and improving traffic data collection and distribution, an Android application was developed to collect information about extraordinary events that take place in a city, providing warnings and alternative routes to drivers and helping them to improve their time management. The developed solution also exploits the existing gaps in other applications, implementing a more specific solution for the Madeira Island traffic condition problems.info:eu-repo/semantics/acceptedVersio

Vertical-external-cavity surface-emitting lasers and quantum dot lasers

The use of cavity to manipulate photon emission of quantum dots (QDs) has been opening unprecedented opportunities for realizing quantum functional nanophotonic devices and also quantum information devices. In particular, in the field of semiconductor lasers, QDs were introduced as a superior alternative to quantum wells to suppress the temperature dependence of the threshold current in vertical-external-cavity surface-emitting lasers (VECSELs). In this work, a review of properties and development of semiconductor VECSEL devices and QD laser devices is given. Based on the features of VECSEL devices, the main emphasis is put on the recent development of technological approach on semiconductor QD VECSELs. Then, from the viewpoint of both single QD nanolaser and cavity quantum electrodynamics (QED), a single-QD-cavity system resulting from the strong coupling of QD cavity is presented. A difference of this review from the other existing works on semiconductor VECSEL devices is that we will cover both the fundamental aspects and technological approaches of QD VECSEL devices. And lastly, the presented review here has provided a deep insight into useful guideline for the development of QD VECSEL technology and future quantum functional nanophotonic devices and monolithic photonic integrated circuits (MPhICs).Comment: 21 pages, 4 figures. arXiv admin note: text overlap with arXiv:0904.369

Modeling the excitation of graphene plasmons in periodic grids of graphene ribbons: an analytical approach

We study electromagnetic scattering and subsequent plasmonic excitations in periodic grids of graphene ribbons. To address this problem, we develop an analytical method to describe the plasmon-assisted absorption of electromagnetic radiation by a periodic structure of graphene ribbons forming a diffraction grating for THz and mid-IR light. The major advantage of this method lies in its ability to accurately describe the excitation of graphene surface plasmons (GSPs) in one-dimensional (1D) graphene gratings without the use of both time-consuming, and computationally-demanding full-wave numerical simulations. We thus provide analytical expressions for the reflectance, transmittance and plasmon-enhanced absorbance spectra, which can be readily evaluated in any personal laptop with little-to-none programming. We also introduce a semi-analytical method to benchmark our previous results and further compare the theoretical data with spectra taken from experiments, to which we observe a very good agreement. These theoretical tools may therefore be applied to design new experiments and cutting-edge nanophotonic devices based on graphene plasmonics.The authors thank N. Asger Mortensen for insightful and valuable comments. PADG acknowledges financial support from Fundação para a Ciência e a Tecnologia (Portugal) from grant No. PD/BI/114376/2016. NMRP and YVB acknowledge financial support from the European Commission through the project “GrapheneDriven Revolutions in ICT and Beyond” (Ref. No. 696656). This work was partially supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Financing UID/FIS/04650/2013. The Center for Nanostructured Graphene is sponsored by the Danish National Research Foundation, Project DNRF103