Increasing Research Productivity in Small Universities: A Case Study

Researchers at small Canadian universities encounter a set of problems which hamper their productivity. The administration of one such institution embarked upon a programme to increase the research output of its faculty which met with spectacular success. This success occurred because the administration signaled its support for research by devoting resources to it and because faculty learned that they could compete for grants successfully.Les chercheurs des petites universités canadiennes rencontrent un ensemble de problèmes qui gênent leur productivité. L'administration d'une petite université a lancé un programme pour augmenter la recherche et il a eu un succès spectacu-laire. Ce résultat a été possible parce que l'administration a signalé son appui en consacrant des ressources à la recherche et les membres de la faculté ont appris qu 'ils pouvaient concourir et réussir à obtenir des subventions

Spitzer Infrared Spectrograph Detection of Molecular Hydrogen Rotational Emission towards Translucent Clouds

Using the Infrared Spectrograph on board the Spitzer Space Telescope, we have detected emission in the S(0), S(1), and S(2) pure-rotational (v = 0-0) transitions of molecular hydrogen (H_2) toward six positions in two translucent high Galactic latitude clouds, DCld 300.2–16.9 and LDN 1780. The detection of these lines raises important questions regarding the physical conditions inside low-extinction clouds that are far from ultraviolet radiation sources. The ratio between the S(2) flux and the flux from polycyclic aromatic hydrocarbons (PAHs) at 7.9 μm averages 0.007 for these six positions. This is a factor of about four higher than the same ratio measured toward the central regions of non-active Galaxies in the Spitzer Infrared Nearby Galaxies Survey. Thus, the environment of these translucent clouds is more efficient at producing rotationally excited H_2 per PAH-exciting photon than the disks of entire galaxies. Excitation analysis finds that the S(1) and S(2) emitting regions are warm (T ≳ 300 K), but comprise no more than 2% of the gas mass. We find that UV photons cannot be the sole source of excitation in these regions and suggest mechanical heating via shocks or turbulent dissipation as the dominant cause of the emission. The clouds are located on the outskirts of the Scorpius-Centaurus OB association and may be dissipating recent bursts of mechanical energy input from supernova explosions. We suggest that pockets of warm gas in diffuse or translucent clouds, integrated over the disks of galaxies, may represent a major source of all non-active galaxy H_2 emission

Radar studies of the planets

The radar measurements phase of the lunar studies involving reflectivity and topographic mapping of the visible lunar surface was ended in December 1972, but studies of the data and production of maps have continued. This work was supported by Manned Spacecraft Center, Houston. Topographic mapping of the equatorial regions of Mars has been carried out during the period of each opposition since that of 1967. The method comprised extended precise traveling time measurements to a small area centered on the subradar point. As measurements continued, planetary motions caused this point to sweep out extensive areas in both latitude and longitude permitting the development of a fairly extensive topographical map in the equatorial region. Radar observations of Mercury and Venus have also been made over the past few years. Refinements of planetary motions, reflectivity maps and determinations of rotation rates have resulted

Commercial-off-the-shelf simulation package interoperability: Issues and futures

Commercial-Off-The-Shelf Simulation Packages (CSPs) are widely used in industry to simulate discrete-event models. Interoperability of CSPs requires the use of distributed simulation techniques. Literature presents us with many examples of achieving CSP interoperability using bespoke solutions. However, for the wider adoption of CSP-based distributed simulation it is essential that, first and foremost, a standard for CSP interoperability be created, and secondly, these standards are adhered to by the CSP vendors. This advanced tutorial is on an emerging standard relating to CSP interoperability. It gives an overview of this standard and presents case studies that implement some of the proposed standards. Furthermore, interoperability is discussed in relation to large and complex models developed using CSPs that require large amount of computing resources. It is hoped that this tutorial will inform the simulation community of the issues associated with CSP interoperability, the importance of these standards and its future

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kB signaling pathway

Mathematical modelling offers a variety of useful techniques to help in understanding the intrinsic behaviour of complex signal transduction networks. From the system engineering point of view, the dynamics of metabolic and signal transduction models can always be described by nonlinear ordinary differential equations (ODEs) following mass balance principles. Based on the state-space formulation, many methods from the area of automatic control can conveniently be applied to the modelling, analysis and design of cell networks. In the present study, dynamic sensitivity analysis is performed on a model of the IB-NF-B signal pathway system. Univariate analysis of the Euclidean-form overall sensitivities shows that only 8 out of the 64 parameters in the model have major influence on the nuclear NF-B oscillations. The sensitivity matrix is then used to address correlation analysis, identifiability assessment and measurement set selection within the framework of least squares estimation and multivariate analysis. It is shown that certain pairs of parameters are exactly or highly correlated to each other in terms of their effects on the measured variables. The experimental design strategy provides guidance on which proteins should best be considered for measurement such that the unknown parameters can be estimated with the best statistical precision. The whole analysis scheme we describe provides efficient parameter estimation techniques for complex cell networks

Sensitivity analysis of circadian entrainment in the space of phase response curves

Sensitivity analysis is a classical and fundamental tool to evaluate the role of a given parameter in a given system characteristic. Because the phase response curve is a fundamental input--output characteristic of oscillators, we developed a sensitivity analysis for oscillator models in the space of phase response curves. The proposed tool can be applied to high-dimensional oscillator models without facing the curse of dimensionality obstacle associated with numerical exploration of the parameter space. Application of this tool to a state-of-the-art model of circadian rhythms suggests that it can be useful and instrumental to biological investigations.Comment: 22 pages, 8 figures. Correction of a mistake in Definition 2.1. arXiv admin note: text overlap with arXiv:1206.414

Physical Controls on Carbonate Intraclasts: Modern Flat Pebbles From Great Salt Lake, Utah

In carbonate‐forming environments, authigenic minerals can cement surface sediments into centimeter‐sized intraclasts that are later reworked into “flat‐pebble” or “edgewise” conglomerates. Flat‐pebble conglomerates comprise only a small portion of facies in modern marine environments but are common in ancient strata, implying that seafloor cements were more widespread in the past. Flat‐pebble conglomerates nearly disappeared after the Ordovician radiation, yet it is unclear if this decline was due to changing seawater chemistry or if increased infaunalization and bioturbation simply worked to break down nascent clasts. We discovered a process analog that produces flat‐pebble conglomerates around the Great Salt Lake, Utah, USA, and studied these facies using field observations, wave models, satellite imagery, petrography, and microanalytic chemical data. Clasts were sourced from wave‐rippled grainstone that cemented in situ in offshore environments. Lake floor cements formed under aragonite saturation states that are lower than modern marine settings, suggesting that physical processes are at least as important as chemical ones. Results from our wave models showed that coarse sediments near the field site experience quiescent periods of up to 6 months between suspension events, allowing isopachous cements to form. Using a simple mathematical framework, we show that the main difference between Great Salt Lake and modern, low‐energy marine settings is that the latter has enough bioturbating organisms to break up clasts. Observations from Great Salt Lake demonstrate how geologic trends in flat‐pebble abundance could largely reflect changes in total infaunal biomass and ecology without requiring regional‐to‐global changes in seawater chemistry