Cooling by Free Convection at High Rayleigh Number of Cylinders Positioned Above a Plane

Free convection cooling of isothermal circular cylinders positioned above a horizontal plane is investigated numerically, using a commercial Computational Fluid Dynamics (CFD) software package. Computation is performed for high Rayleigh number, in the range 109 − 1011. Chien’s turbulence model of low-Reynolds-number K-ε is used, with Prandtl number of 0.707, corresponding to air near standard conditions. Influence of the underlying plane on heat transfer from the cylinders' surface is examined. As the gap between the plane and cylinders is narrowed, a pattern can be seen whereby heat transfer reaches a minimum that moves closer to the cylinder surface with higher Rayleigh number. The plane’s thermal condition, adiabatic versus isothermal, produces no significant difference in the heat transfer for the present range of gap ratio, in contrast to laminar case

Sub-Terahertz Monochromatic Transduction with Semiconductor Acoustic Nanodevices

We demonstrate semiconductor superlattices or nanocavities as narrow band acoustic transducers in the sub-terahertz range. Using picosecond ultrasonics experiments in the transmission geometry with pump and probe incident on opposite sides of the thick substrate, phonon generation and detection processes are fully decoupled. Generating with the semiconductor device and probing on the metal, we show that both superlattices and nanocavities generate spectrally narrow wavepackets of coherent phonons with frequencies in the vicinity of the zone center and time durations in the nanosecond range, qualitatively different from picosecond broadband pulses usually involved in picosecond acoustics with metal generators. Generating in the metal and probing on the nanoacoustic device, we furthermore evidence that both nanostructured semiconductor devices may be used as very sensitive and spectrally selective detectors

The Abelian Manna model on two fractal lattices

We analyze the avalanche size distribution of the Abelian Manna model on two different fractal lattices with the same dimension d_g=ln(3)/ln(2), with the aim to probe for scaling behavior and to study the systematic dependence of the critical exponents on the dimension and structure of the lattices. We show that the scaling law D(2-tau)=d_w generalizes the corresponding scaling law on regular lattices, in particular hypercubes, where d_w=2. Furthermore, we observe that the lattice dimension d_g, the fractal dimension of the random walk on the lattice d_w, and the critical exponent D, form a plane in 3D parameter space, i.e. they obey the linear relationship D=0.632(3) d_g + 0.98(1) d_w - 0.49(3).Comment: 4 pages, 3 figures, 3 tables, submitted to PRE as a Brief Repor

Toxoplasma MIC2 Is a Major Determinant of Invasion and Virulence

Like its apicomplexan kin, the obligate intracellular protozoan Toxoplasma gondii actively invades mammalian cells and uses a unique form of gliding motility. The recent identification of several transmembrane adhesive complexes, potentially capable of gripping external receptors and the sub-membrane actinomyosin motor, suggests that the parasite has multiple options for host-cell recognition and invasion. To test whether the transmembrane adhesin MIC2, together with its partner protein M2AP, participates in a major invasion pathway, we utilized a conditional expression system to introduce an anhydrotetracycline-responsive mic2 construct, allowing us to then knockout the endogenous mic2 gene. Conditional suppression of MIC2 provided the first opportunity to directly determine the role of this protein in infection. Reduced MIC2 expression resulted in mistrafficking of M2AP, markedly defective host-cell attachment and invasion, the loss of helical gliding motility, and the inability to support lethal infection in a murine model of acute toxoplasmosis. Survival of mice infected with MIC2-deficient parasites correlated with lower parasite burden in infected tissues, an attenuated inflammatory immune response, and induction of long-term protective immunity. Our findings demonstrate that the MIC2 protein complex is a major virulence determinant for Toxoplasma infection and that MIC2-deficient parasites constitute an effective live-attenuated vaccine for experimental toxoplasmosis

Analog of Astrophysical Magnetorotational Instability in a Couette-Taylor Flow of Polymer Fluids

We report experimental observation of an instability in a Couette-Taylor flow of a polymer fluid in a thin gap between two coaxially rotating cylinders in a regime where their angular velocity decreases with the radius while the specific angular momentum increases with the radius. In the considered regime, neither the inertial Rayleigh instability nor the purely elastic instability are possible. We propose that the observed "elasto-rotational" instability is an analog of the magnetorotational instability which plays a fundamental role in astrophysical Keplerian accretion disks.Comment: 4 pages, 1 figur

Speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of HbF by 5-azacytidine

In the baboon (Papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (I gamma-chain) or valine (V gamma) may be present. This situation obtains in baboons that are sometimes designated as Papio anubis, Papio hamadryas, and Papio papio. However, in Papio cynocephalus, although the I gamma-chains are identical with those in the above mentioned types, the V gamma-chains have the substitutions ala----gly at residue 9 and ala----val at residue 23. The V gamma-chains of P. cynocephalus are called V gamma C to distinguish them from the V gamma A-chains of P. anubis, etc. A single cynocephalus animal has been found to have only normal I gamma-chains and I gamma C-chains (that is, glycine in residue 9, valine in 23, and isoleucine in 75). When HbF is produced in response to stress with 5-azacytidine, P. anubis baboons respond with greater production than do P. cynocephalus, and hybrids fall between. Minimal data on P. hamadryas and P. papio suggest an even lower response than P. cynocephalus. As HbF increases under stress, the ratio of I gamma to V gamma-chains changes from the value in the adult or juvenile baboon toward the ratio in the newborn baboon. However, it does not attain the newborn value. The V gamma A and V gamma C-genes respond differently to stress. In hybrids, the production of V gamma A- chains exceeds that of V gamma C-chains. A controlling factor in cis apparently is present and may be responsible for the species-related extent of total HbF production. It may be concluded that the more primitive the cell in the erythroid maturation series that has been subjected to 5-azacytidine, the more active is the I gamma-gene

Trabecular bone structure correlates with hand posture and use in hominoids

Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor and manipulative behaviours across extant hominoids may be reflected in differences in trabecular bone structure. The hand is a promising region for trabecular analysis, as it is the direct contact between the individual and the environment and joint positions at peak loading vary amongst extant hominoids. Building upon traditional volume of interest-based analyses, we apply a whole-epiphysis analytical approach using high-resolution microtomographic scans of the hominoid third metacarpal to investigate whether trabecular structure reflects differences in hand posture and loading in knuckle-walking (Gorilla, Pan), suspensory (Pongo, Hylobates and Symphalangus) and manipulative (Homo) taxa. Additionally, a comparative phylogenetic method was used to analyse rates of evolutionary changes in trabecular parameters. Results demonstrate that trabecular bone volume distribution and regions of greatest stiffness (i.e., Young's modulus) correspond with predicted loading of the hand in each behavioural category. In suspensory and manipulative taxa, regions of high bone volume and greatest stiffness are concentrated on the palmar or distopalmar regions of the metacarpal head, whereas knuckle-walking taxa show greater bone volume and stiffness throughout the head, and particularly in the dorsal region; patterns that correspond with the highest predicted joint reaction forces. Trabecular structure in knuckle-walking taxa is characterised by high bone volume fraction and a high degree of anisotropy in contrast to the suspensory brachiators. Humans, in which the hand is used primarily for manipulation, have a low bone volume fraction and a variable degree of anisotropy. Finally, when trabecular parameters are mapped onto a molecular-based phylogeny, we show that the rates of change in trabecular structure vary across the hominoid clade. Our results support a link between inferred behaviour and trabecular structure in extant hominoids that can be informative for reconstructing behaviour in fossil primates

Spitzer 70 Micron Source Counts in GOODS-North

We present ultradeep Spitzer 70 μm observations of GOODS-North (Great Observatories Origins Deep Survey). For the first time, the turnover in the 70 μm Euclidean-normalized differential source counts is observed. We derive source counts down to a flux density of 1.2 mJy. From the measured source counts and fluctuation analysis, we estimate a power-law approximation of the faint 70 μm source counts of dN/dS ∝ S^−1.6, consistent with that observed for the faint 24 μm sources. An extrapolation of the 70 μm source counts to zero flux density implies a total extragalactic background light (EBL) of 7.4 ± 1.9 nW m^−2 sr^−1. The source counts above 1.2 mJy account for about 60% of the estimated EBL. From fluctuation analysis, we derive a photometric confusion level of σc = 0.30 ± 0.15 mJy (q = 5) for the Spitzer 70 μm band

The Infrared Properties of Submillimeter Galaxies: Clues From Ultra-Deep 70 Micron Imaging

We present 70 micron properties of submillimeter galaxies (SMGs) in the Great Observatories Origins Deep Survey (GOODS) North field. Out of thirty submillimeter galaxies (S_850 > 2 mJy) in the central GOODS-N region, we find two with secure 70 micron detections. These are the first 70 micron detections of SMGs. One of the matched SMGs is at z ~ 0.5 and has S_70/S_850 and S_70/S_24 ratios consistent with a cool galaxy. The second SMG (z = 1.2) has infrared-submm colors which indicate it is more actively forming stars. We examine the average 70 micron properties of the SMGs by performing a stacking analysis, which also allows us to estimate that S_850 > 2 mJy SMGs contribute 9 +- 3% of the 70 micron background light. The S_850/S_70 colors of the SMG population as a whole is best fit by cool galaxies, and because of the redshifting effects these constraints are mainly on the lower z sub-sample. We fit Spectral Energy Distributions (SEDs) to the far-infrared data points of the two detected SMGs and the average low redshift SMG (z_{median}= 1.4). We find that the average low-z SMG has a cooler dust temperature than local ultraluminous infrared galaxies (ULIRGs) of similar luminosity and an SED which is best fit by scaled up versions of normal spiral galaxies. The average low-z SMG is found to have a typical dust temperature T = 21 -- 33 K and infrared luminosity L_{8-1000 micron} = 8.0 \times 10^11 L_sun. We estimate the AGN contribution to the total infrared luminosity of low-z SMGs is less than 23%.Comment: Accepted by ApJ. 14 pages, 6 figures. Minor revisions 20th Dec 200