4,028 research outputs found
Effects of intra- and inter-laminar resin content on the mechanical properties of toughened composite materials
Composite materials having multiphase toughened matrix systems and laminate architectures characterized by resin-rich interlaminar layers (RIL) have been the subject of much recent attention. Such materials are likely to find applications in thick compressively loaded structures such as the keel area of commercial aircraft fuselages. The effects of resin content and its interlaminar and intralaminar distribution on mechanical properties were investigated with test and analysis of two carbon-epoxy systems. The RIL was found to reduce the in situ strengthening effect for matrix cracking in laminates. Mode 2 fracture toughness was found to increase with increasing RIL thickness over the range investigated, and Mode 1 interlaminar toughness was negligibly affected. Compressive failure strains were found to increase with increasing resin content for specimens having no damage, holes, and impact damage. Analytical tools for predicting matrix cracking of off-axis plies and damage tolerance in compression after impact (CAI) were successfully applied to materials with RIL
Cosmologies with a time dependent vacuum
The idea that the cosmological term, Lambda, should be a time dependent
quantity in cosmology is a most natural one. It is difficult to conceive an
expanding universe with a strictly constant vacuum energy density, namely one
that has remained immutable since the origin of time. A smoothly evolving
vacuum energy density that inherits its time-dependence from cosmological
functions, such as the Hubble rate or the scale factor, is not only a
qualitatively more plausible and intuitive idea, but is also suggested by
fundamental physics, in particular by quantum field theory (QFT) in curved
space-time. To implement this notion, is not strictly necessary to resort to ad
hoc scalar fields, as usually done in the literature (e.g. in quintessence
formulations and the like). A "running" Lambda term can be expected on very
similar grounds as one expects (and observes) the running of couplings and
masses with a physical energy scale in QFT. Furthermore, the experimental
evidence that the equation of state of the dark energy could be evolving with
time/redshift (including the possibility that it might currently behave
phantom-like) suggests that a time-variable Lambda term (possibly accompanied
by a variable Newton's gravitational coupling G=G(t)) could account in a
natural way for all these features. Remarkably enough, a class of these models
(the "new cosmon") could even be the clue for solving the old cosmological
constant problem, including the coincidence problem.Comment: LaTeX, 15 pages, 4 figure
Exercise for acute respiratory infections
No abstract available
Impact of a hospice rapid response service on preferred place of death, and costs
Background: Many people with a terminal illness would prefer to die at home. A new palliative rapid response service (RRS) provided by a large hospice provider in South East England was evaluated (2010) to provide evidence of impact on achieving preferred place of death and costs. The RRS was delivered by a team of trained health care assistants and available 24/7. The purpose of this study was to (i) compare the characteristics of RRS users and non-users, (ii) explore differences in the proportions of users and non-users dying in the place of their choice, (iii) monitor the whole system service utilisation of users and non-users, and compare costs. Methods: All hospice patients who died with a preferred place of death recorded during an 18 month period were included. Data (demographic, preferences for place of death) were obtained from hospice records. Dying in preferred place was modelled using stepwise logistic regression analysis. Service use data (period between referral to hospice and death) were obtained from general practitioners, community providers, hospitals, social services, hospice, and costs calculated using validated national tariffs. Results: Of 688 patients referred to the hospice when the RRS was operational, 247 (35.9 %) used it. Higher proportions of RRS users than non-users lived in their own homes with a co-resident carer (40.3 % vs. 23.7 %); more non-users lived alone or in residential care (58.8 % vs. 76.3 %). Chances of dying in the preferred place were enhanced 2.1 times by being a RRS user, compared to a non-user, and 1.5 times by having a co-resident carer, compared to living at home alone or in a care home. Total service costs did not differ between users and non-users, except when referred to hospice very close to death (users had higher costs). Conclusions: Use of the RRS was associated with increased likelihood of dying in the preferred place. The RRS is cost neutral
Modelling of atmospheric boundary layer: Generation of shear.
Roughness length, z0 and friction velocity, u* are the defining parameters of wind log profile that must be matched in wind tunnel simulation. To fully understand the role of these parameters, the basics and review from the primitive equations and its relation to the logarithmic profile obtained for wind tunnel conditions were discussed. The problem of roughness, although well known, still needs to be addressed more rigorously especially when determining values of z0 and u* from wind tunnel data and their relation to the roughness element geometry. A review of classic literature and new published material were carried out, focusing on the applicability to wind tunnel modelling
Effective growth of matter density fluctuations in the running LCDM and LXCDM models
We investigate the matter density fluctuations \delta\rho/\rho for two dark
energy (DE) models in the literature in which the cosmological term \Lambda is
a running parameter. In the first model, the running LCDM model, matter and DE
exchange energy, whereas in the second model, the LXCDM model, the total DE and
matter components are conserved separately. The LXCDM model was proposed as an
interesting solution to the cosmic coincidence problem. It includes an extra
dynamical component, the "cosmon" X, which interacts with the running \Lambda,
but not with matter. In our analysis we make use of the current value of the
linear bias parameter, b^2(0)= P_{GG}/P_{MM}, where P_{MM} ~
(\delta\rho/\rho)^2 is the present matter power spectrum and P_{GG} is the
galaxy fluctuation power spectrum. The former can be computed within a given
model, and the latter is found from the observed LSS data (at small z) obtained
by the 2dF galaxy redshift survey. It is found that b^2(0)=1 within a 10%
accuracy for the standard LCDM model. Adopting this limit for any DE model and
using a method based on the effective equation of state for the DE, we can set
a limit on the growth of matter density perturbations for the running LCDM
model, the solution of which is known. This provides a good test of the
procedure, which we then apply to the LXCDM model in order to determine the
physical region of parameter space, compatible with the LSS data. In this
region, the LXCDM model is consistent with known observations and provides at
the same time a viable solution to the cosmic coincidence problem.Comment: LaTeX, 38 pages, 8 figures. Version accepted in JCA
Perturbations in the relaxation mechanism for a large cosmological constant
Recently, a mechanism for relaxing a large cosmological constant (CC) has
been proposed [arxiv:0902.2215], which permits solutions with low Hubble rates
at late times without fine-tuning. The setup is implemented in the LXCDM
framework, and we found a reasonable cosmological background evolution similar
to the LCDM model with a fine-tuned CC. In this work we analyse analytically
the perturbations in this relaxation model, and we show that their evolution is
also similar to the LCDM model, especially in the matter era. Some tracking
properties of the vacuum energy are discussed, too.Comment: 18 pages, LaTeX; discussion improved, accepted by CQ
Tyrosine kinase inhibitors for the therapy of anaplastic thyroid cancer
Anaplastic thyroid cancer (ATC) is often incurable so new therapeutic approaches are needed. Tyrosine kinases inhibitors (such as imanitib, sunitinib or sorafenib) are under evaluation for the treatment of ATC. Other vascular disrupting agents, such as combretastatin A4 phosphate, and antiangiogenic agents, such as aplidin, PTK787/ZK222584 and human VEGF monoclonal antibodies (bevacizumab, cetuximab), have been evaluated. Small-molecule adenosine triphosphate competitive inhibitors directed intracellularly at EGFRs tyrosine kinase, such as erlotinib or gefitinib, are also studied. Furthermore, new molecules have been shown to be active against ATC, such as CLM94 and CLM3. However, more research is needed to finally identify therapies able to control and to cure this disease
Hubble expansion and structure formation in the "running FLRW model" of the cosmic evolution
A new class of FLRW cosmological models with time-evolving fundamental
parameters should emerge naturally from a description of the expansion of the
universe based on the first principles of quantum field theory and string
theory. Within this general paradigm, one expects that both the gravitational
Newton's coupling, G, and the cosmological term, Lambda, should not be strictly
constant but appear rather as smooth functions of the Hubble rate. This
scenario ("running FLRW model") predicts, in a natural way, the existence of
dynamical dark energy without invoking the participation of extraneous scalar
fields. In this paper, we perform a detailed study of these models in the light
of the latest cosmological data, which serves to illustrate the
phenomenological viability of the new dark energy paradigm as a serious
alternative to the traditional scalar field approaches. By performing a joint
likelihood analysis of the recent SNIa data, the CMB shift parameter, and the
BAOs traced by the Sloan Digital Sky Survey, we put tight constraints on the
main cosmological parameters. Furthermore, we derive the theoretically
predicted dark-matter halo mass function and the corresponding redshift
distribution of cluster-size halos for the "running" models studied. Despite
the fact that these models closely reproduce the standard LCDM Hubble
expansion, their normalization of the perturbation's power-spectrum varies,
imposing, in many cases, a significantly different cluster-size halo redshift
distribution. This fact indicates that it should be relatively easy to
distinguish between the "running" models and the LCDM cosmology using realistic
future X-ray and Sunyaev-Zeldovich cluster surveys.Comment: Version published in JCAP 08 (2011) 007: 1+41 pages, 6 Figures, 1
Table. Typos corrected. Extended discussion on the computation of the
linearly extrapolated density threshold above which structures collapse in
time-varying vacuum models. One appendix, a few references and one figure
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