516 research outputs found
Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo
After activation, Langerhans cells (LC), a distinct subpopulation of epidermis-resident dendritic cells, migrate from skin to lymph nodes where they regulate the magnitude and quality of immune responses initiated by epicutaneously applied antigens. Modulation of LC-keratinocyte adhesion is likely to be central to regulation of LC migration. LC express high levels of epithelial cell adhesion molecule (EpCAM; CD326), a cell-surface protein that is characteristic of some epithelia and many carcinomas and that has been implicated in intercellular adhesion and metastasis. To gain insight into EpCAM function in a physiologic context in vivo, we generated conditional knockout mice with EpCAM-deficient LC and characterized them. Epidermis from these mice contained increased numbers of LC with normal levels of MHC and costimulatory molecules and T-cell-stimulatory activity in vitro. Migration of EpCAM-deficient LC from skin explants was inhibited, but chemotaxis of dissociated LC was not. Correspondingly, the ability of contact allergen-stimulated, EpCAM-deficient LC to exit epidermis in vivo was delayed, and strikingly fewer hapten-bearing LC subsequently accumulated in lymph nodes. Attenuated migration of EpCAM-deficient LC resulted in enhanced contact hypersensitivity responses as previously described in LC-deficient mice. Intravital microscopy revealed reduced translocation and dendrite motility in EpCAM-deficient LC in vivo in contact allergen-treated mice. These results conclusively link EpCAM expression to LC motility/migration and LC migration to immune regulation. EpCAM appears to promote LC migration from epidermis by decreasing LC-keratinocyte adhesion and may modulate intercellular adhesion and cell movement within in epithelia during development and carcinogenesis in an analogous fashion
Progress towards an accurate determination of the Boltzmann constant by Doppler spectroscopy
In this paper, we present significant progress performed on an experiment
dedicated to the determination of the Boltzmann constant, k, by accurately
measuring the Doppler absorption profile of a line in a gas of ammonia at
thermal equilibrium. This optical method based on the first principles of
statistical mechanics is an alternative to the acoustical method which has led
to the unique determination of k published by the CODATA with a relative
accuracy of 1.7 ppm. We report on the first measurement of the Boltzmann
constant by laser spectroscopy with a statistical uncertainty below 10 ppm,
more specifically 6.4 ppm. This progress results from improvements in the
detection method and in the statistical treatment of the data. In addition, we
have recorded the hyperfine structure of the probed saQ(6,3) rovibrational line
of ammonia by saturation spectroscopy and thus determine very precisely the
induced 4.36 (2) ppm broadening of the absorption linewidth. We also show that,
in our well chosen experimental conditions, saturation effects have a
negligible impact on the linewidth. Finally, we draw the route to future
developments for an absolute determination of with an accuracy of a few ppm.Comment: 22 pages, 11 figure
Measurement of J/Psi production in pp collisions at sqrt(s)=2.76 and 7 TeV with ALICE
We present results from the ALICE experiment on the inclusive J/Psi
production in pp collisions at sqrt(s)=2.76 and 7 TeV. The integrated and
differential cross sections are evaluated down to pT=0 in two rapidity ranges,
|y|<0.9 and 2.5<y<4, in the dielectron and dimuon decay channel respectively.
The measurement at sqrt(s)=2.76 TeV, the same energy as Pb-Pb collisions,
provides a crucial reference for the study of hot nuclear matter effects on
J/Psi production. The J/Psi yield in pp collisions at sqrt(s)=7 TeV has also
been studied as a function of the charged particle multiplicity and first
results are presented.Comment: 4 pages, 4 figures, parallel talk at Quark Matter 2011, Annecy,
Franc
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Impacts of 1.5 versus 2.0 °c on cereal yields in the West African Sudan Savanna
To reduce the risks of climate change, governments agreed in the Paris Agreement to limit global temperature rise to less than 2.0 °C above pre-industrial levels, with the ambition to keep warming to 1.5 °C. Charting appropriate mitigation responses requires information on the costs of mitigating versus associated damages for the two levels of warming. In this assessment, a critical consideration is the impact on crop yields and yield variability in regions currently challenged by food insecurity. The current study assessed impacts of 1.5 °C versus 2.0 °C on yields of maize, pearl millet and sorghum in the West African Sudan Savanna using two crop models that were calibrated with common varieties from experiments in the region with management reflecting a range of typical sowing windows. As sustainable intensification is promoted in the region for improving food security, simulations were conducted for both current fertilizer use and for an intensification case (fertility not limiting). With current fertilizer use, results indicated 2% units higher losses for maize and sorghum with 2.0 °C compared to 1.5 °C warming, with no change in millet yields for either scenario. In the intensification case, yield losses due to climate change were larger than with current fertilizer levels. However, despite the larger losses, yields were always two to three times higher with intensification, irrespective of the warming scenario. Though yield variability increased with intensification, there was no interaction with warming scenario. Risk and market analysis are needed to extend these results to understand implications for food security
Sterile neutrinos and supernova nucleosynthesis
A light sterile neutrino species has been introduced to explain
simultaneously the solar and atmospheric neutrino puzzles and the results of
the LSND experiment, while providing for a hot component of dark matter.
Employing this scheme of neutrino masses and mixings, we show how
matter-enhanced active-sterile neutrino transformation followed by
active-active neutrino transformation can solve robustly the neutron deficit
problem encountered by models of r-process nucleosynthesis associated with
neutrino-heated supernova ejecta.Comment: 29 pages, 3 postscript figures, submitted to Phys. Rev.
Theory and applications of atomic and ionic polarizabilities
Atomic polarization phenomena impinge upon a number of areas and processes in
physics. The dielectric constant and refractive index of any gas are examples
of macroscopic properties that are largely determined by the dipole
polarizability. When it comes to microscopic phenomena, the existence of
alkaline-earth anions and the recently discovered ability of positrons to bind
to many atoms are predominantly due to the polarization interaction. An
imperfect knowledge of atomic polarizabilities is presently looming as the
largest source of uncertainty in the new generation of optical frequency
standards. Accurate polarizabilities for the group I and II atoms and ions of
the periodic table have recently become available by a variety of techniques.
These include refined many-body perturbation theory and coupled-cluster
calculations sometimes combined with precise experimental data for selected
transitions, microwave spectroscopy of Rydberg atoms and ions, refractive index
measurements in microwave cavities, ab initio calculations of atomic structures
using explicitly correlated wave functions, interferometry with atom beams, and
velocity changes of laser cooled atoms induced by an electric field. This
review examines existing theoretical methods of determining atomic and ionic
polarizabilities, and discusses their relevance to various applications with
particular emphasis on cold-atom physics and the metrology of atomic frequency
standards.Comment: Review paper, 44 page
Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases.
Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32-80; lesion diameter 7.0 cm, 1-14.5; median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumatoid arthritis (n = 3, 8%), myasthenia gravis (n = 2, 6%), asthma (n = 2, 6%), scleroderma, Sjögren syndrome, pure red cell aplasia, Grave's disease and anti-IgLON5 syndrome (each n = 1, 3%). Among 11 primary thymic MALT lymphomas, remnants of LESA-like TH were found in two cases (18%). In summary, LESA-like TH shows a striking association with autoimmunity and predisposes to lymphomas. Thus, a hematologic and rheumatologic workup should become standard in patients diagnosed with LESA-like TH. Radiologists and clinicians should be aware of LESA-like TH as a differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases
Improved Measurements of Branching Fractions for B->Kpi, pipi and KK Decays
We report improved measurements of branching fractions for ,
, and decays based on a data sample of 85.0
million pairs collected at the resonance with the
Belle detector at the KEKB storage ring. This data sample is almost
three times larger than the sample previously used. We observe clear signals
for , and decays and set upper limits on
decays. The results can be used to give model-dependent
constraints on the CKM angle , as well as limits on the hadronic
uncertainty in the time-dependent analysis of the angle .Comment: 10 pages, 1 figure, 4 tables. Submitted to Phys. Rev. D Rapid
Communications. Several corrections were mad
Status of Muon Collider Research and Development and Future Plans
The status of the research on muon colliders is discussed and plans are
outlined for future theoretical and experimental studies. Besides continued
work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy
collider, many studies are now concentrating on a machine near 0.1 TeV (CoM)
that could be a factory for the s-channel production of Higgs particles. We
discuss the research on the various components in such muon colliders, starting
from the proton accelerator needed to generate pions from a heavy-Z target and
proceeding through the phase rotation and decay ()
channel, muon cooling, acceleration, storage in a collider ring and the
collider detector. We also present theoretical and experimental R & D plans for
the next several years that should lead to a better understanding of the design
and feasibility issues for all of the components. This report is an update of
the progress on the R & D since the Feasibility Study of Muon Colliders
presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A.
Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics
(Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics,
Accelerators and Beam
\psi(2S) Decays into \J plus Two Photons
Using \gamma \gamma J/\psi, J/\psi \ra e^+ e^- and events
from a sample of \psip decays collected with the BESII
detector, the branching fractions for \psip\ra \pi^0\J, \eta\J, and
\psi(2S)\ar\gamma\chi_{c1},\gamma\chi_{c2}\ar\gamma\gamma\jpsi are measured
to be B(\psip\ra \pi^0\J) = (1.43\pm0.14\pm0.13)\times 10^{-3}, B(\psip\ra
\eta\J) = (2.98\pm0.09\pm0.23)%,
B(\psi(2S)\ar\gamma\chi_{c1}\ar\gamma\gamma\jpsi) = (2.81\pm0.05\pm 0.23)%,
and B(\psi(2S)\ar\gamma\chi_{c2}\ar\gamma\gamma\jpsi) = (1.62\pm0.04\pm
0.12)%.Comment: 7 pages, 6 figures. submitted to Phys. Rev.
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