510 research outputs found
Urban outdoor thermal comfort of the hot-humid region
The study on outdoor comfort is becoming popular due to the fact that the thermoregulatory model is seen as inadequate in explaining outdoor thermal comfort conditions. Hot-humid region can be said as experiencing a critical environmental condition because of its constantly high temperature and humidity throughout the year. Thus, this study focus on the assessment of thermal comfort of outdoor urban spaces in Kuala Lumpur, Malaysia (3° 9’N and 101° 44’E). Survey on human response towards outdoor thermal comfort in hot-humid climate of Kuala Lumpur, Malaysia was carried out during day time between 0900h to 1800h along with measurement of environmental parameters such as air temperature (°C), wind velocity (m/s), radiant temperature (°C), relative humidity (%) and solar radiation (lux). A total of 123 samples were involved in this study which took place within four sites around Kuala Lumpur. Survey results were then correlated with the environmental parameters to further develop the comfort zone for hot-humid outdoor environment specifically for Kuala Lumpur and, generally, for hot-humid regions
Potent bactericidal efficacy of copper oxide impregnated non-porous solid surfaces
BACKGROUND: The role of fomites and the environment in nosocomial infections is becoming widely recognized. In this paper we discuss the use of Cupron copper oxide impregnated non-porous solid surface in the hospital setting and present in vitro testing data via USA Environmental Protection Agency (EPA) approved testing protocols that demonstrate the efficacy of these products to assist in reduction in environmental contamination and potentially nosocomial infections. RESULTS: The two countertops tested passed all the acceptance criteria by the EPA (>99.9% kill within 2 hours of exposure) killing a range of bacterial pathogens on the surface of the countertops even after repeated exposure of the countertops to the pathogen, and multiple wet and dry abrasion cycles. CONCLUSIONS: Cupron enhanced EOS countertops thus may be an important adjunct to be used in hospital settings to reduce environmental bioburden and potentially nosocomial infections
Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition
Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in theory, more likely to be relevant. Because pyroptosis (ie, cell death resulting from inflammasome activation) is typically observed in IRI, we speculated that aPC ameliorates IRI by inhibiting inflammasome activation. Here we analyzed the impact of aPC on inflammasome activity in myocardial and renal IRIs. aPC treatment before or after myocardial IRI reduced infarct size and Nlrp3 inflammasome activation in mice. Kinetic in vivo analyses revealed that Nlrp3 inflammasome activation preceded myocardial injury and apoptosis, corroborating a pathogenic role of the Nlrp3 inflammasome. The constitutively active Nlrp3A350V mutation abolished the protective effect of aPC, demonstrating that Nlrp3 suppression is required for aPC-mediated protection from IRI. In vitro aPC inhibited inflammasome activation in macrophages, cardiomyocytes, and cardiac fibroblasts via proteinase-activated receptor 1 (PAR-1) and mammalian target of rapamycin complex 1 (mTORC1) signaling. Accordingly, inhibiting PAR-1 signaling, but not the anticoagulant properties of aPC, abolished the ability of aPC to restrict Nlrp3 inflammasome activity and tissue damage in myocardial IRI. Targeting biased PAR-1 signaling via parmodulin-2 restricted mTORC1 and Nlrp3 inflammasome activation and limited myocardial IRI as efficiently as aPC. The relevance of aPC-mediated Nlrp3 inflammasome suppression after IRI was corroborated in renal IRI, where the tissue protective effect of aPC was likewise dependent on Nlrp3 inflammasome suppression. These studies reveal that aPC protects from IRI by restricting mTORC1-dependent inflammasome activation and that mimicking biased aPC PAR-1 signaling using parmodulins may be a feasible therapeutic approach to combat IRI
Investigating the behaviour of ASHRAE, Bedford, and Nicol thermal scales when translated into the Arabic language
With the global spread of thermal comfort studies, thermal scales are translated into different languages to adapt local context in which the studies are applied. However, translating thermal comfort studies does not maintain the scales' behaviour associated with the original English versions. Behaviour differences include irregular categories' width, asymmetry, and deviation of the middle category centre from the centre of the thermal continuum. These differences have a negative influence on the results of thermal comfort studies and their accuracy. Applying the successive categories method, this paper explores the change in ASHRAE, Bedford, and Nicol scales' behaviour when translated into the Arabic language. The translated scales were integrated into questionnaires distributed among female high school students in Muscat, the capital city of Oman, as part of a larger survey that lasted for a whole year. The findings revealed the deviation of the translated scales from the original assumptions of the English versions. This included categories' irregular widths and asymmetry in addition to the deviation of the centre of the middle categories from the centre of the thermal continuum. Besides, it was found that both ASHRAE and Bedford scales covered different ranges on the thermal continuum, which questions their assumed equivalence. Based on these findings, the accuracy of the thermal comfort analysis is negatively affected. Considering the sensitivity of scales' behaviour to the used phrases, further explorations implementing the terms examined in this study are recommended. Abstract With the global spread of thermal comfort studies, thermal scales are translated into different languages to adapt local context in which the studies are applied. However, translating thermal comfort studies does not maintain the scales' behaviour associated with the original English versions. Behaviour differences include irregular categories' width, asymmetry, and deviation of the middle category centre from the centre of the thermal continuum. These differences have a negative influence on the results of thermal comfort studies and their accuracy. Applying the successive categories method, this paper explores the change in ASHRAE, Bedford, and Nicol scales' behaviour when translated into the Arabic language. The translated scales were integrated into questionnaires distributed among female high school students in Muscat, the capital city of Oman, as part of a larger survey that lasted for a whole year. The findings revealed the deviation of the translated scales from the original assumptions of the English versions. This included categories' irregular widths and asymmetry in addition to the deviation of the centre of the middle categories from the centre of the thermal continuum. Besides, it was found that both ASHRAE and Bedford scales covered different ranges on the thermal continuum, which questions their assumed equivalence. Based on these findings, the accuracy of the thermal comfort analysis is negatively affected. Considering the sensitivity of scales' behaviour to the used phrases, further explorations implementing the terms examined in this study are recommended
Using a New Programme to Predict Thermal Comfort as a Base to Design Energy Efficient Buildings
A strong relationship relates the thermal comfort and the consumption of energy, especially in the hot arid climate where the installation of HVAC systems is unavoidable. In fact, it has been reported that the HVAC systems are responsible for consuming huge amounts of the total energy used by the buildings that can globally reach up to 40% of the total primary energy requirement. The future estimations indicate that the energy consumption is likely to continue growing in the developed economies to exceed that of the developed countries in 2020. Under these situations, it seems that the shift towards more energy efficient buildings is not an option. Because part of any successful environmental design is to understand the potentials of the site, the proposed programme (THERCOM) assists in weighing the indoor and outdoor thermal comfort in different climates in order to provide better understanding of the site environment as well as testing the thermal comfort chances of the initial concepts
ANALISIS PENENTUAN TARIF KAMAR HOTEL DENGAN METODE ACTIVITY BASED COSTING: (Studi Kasus Pada Hotel Sylvia Maumere)
This study aims to determine the calculation of hotel room rates using the Activity Based Costing method and the comparison of the calculation of hotel room rates based on the traditional methods used by hotel management with Activity Based Costing. The research method used is quantitative descriptive analysis method. The data collection method used in this research is by using the observation method, the interview method, and the documentation method. The results of the calculation of room rental rates using the Activity Based Costing method approach, namely, for the Superior Twin room type of Rp. 216,648.77 for the Superior Double room type of Rp. 236,680.56 for the Superior Triple room type of Rp. 331,751.82 for the Deluxe room type of Rp. IDR 480,014.08 and for the Suite room type is IDR 3,016,106.64. There is a difference in room rental rates that are lower for the types of Superior Twin, Superior Double, and Superior Triple rooms from the calculation results of the Activity Based Costing method with the calculation of the company using the traditional method approach, namely Rp. 131,588.74, Rp. 111,886.26 and respectively. IDR 144,318.09. Meanwhile, the higher room rental rates using the Activity Based Costing method, namely the Deluxe and Suite types of Rp.75,944.17 and Rp.2,144,770.64
Antixenosis, antibiosis, and potential yield compensatory response in barley cultivars exposed to wheat stem sawfly (hymenoptera: Cephidae) under field conditions
Wheat stem sawfly, Cephus cinctus Norton, is an economically serious pest of cereals grown in North America. Barley cultivars were previously planted as resistant crops in rotations to manage C. cinctus, but due to increasing levels of injury to this crop, this is no longer a valid management tactic in Montana. Therefore, we aimed to understand antixenosis (behavioral preference), antibiosis (mortality), and potential yield compensation (increased productivity in response to stem injuries) in barley exposed to C. cinctus. We examined these traits in eight barley cultivars. Antixenosis was assessed by counting number of eggs per stem and antibiosis was assessed by counting infested stems, dead larvae, and stems cut by mature larvae. Potential yield compensation was evaluated by comparing grain yield from three categories of stem infestation: 1) uninfested, 2) infested with dead larva, and 3) infested cut by mature larva at crop maturity. We found the greatest number of eggs per infested stem (1.80 ± 0.04), the highest proportion of infested stems (0.63 ± 0.01), and the highest proportion of cut stems (0.33 ± 0.01) in \u27Hockett\u27. Seven out of eight cultivars had greater grain weight for infested stems than for uninfested stems. These cultivars may have compensatory responses to larval feeding injury. Overall, these barley cultivars contain varying levels of antixenosis, antibiosis, and differing levels of yield compensation. Our results provide foundational knowledge on barley traits that will provide a framework to further develop C. cinctus resistant or tolerant barley cultivars
Effect of Precipitation and Temperature on Larval Survival of Cephus cinctus (Hymenoptera: Cephidae) in Barley Cultivars
Host plant traits strongly affect survivorship of insect herbivores, and host suitability is especially important for the wheat stem sawfly, Cephus cinctus Norton, which spends its entire egg, larval, and pupal periods in a single stem. Measuring larval survival inside stems from egg hatch through diapause-mediated dormancy is a potential measure of population size for the next year but is also useful in assessing effects of growing season precipitation and temperature. Larval growth is synchronized with host plant growth, and the larva cannot switch hosts. Thus, incorporating plant physiological time, as growing degree days (GDD), may yield a better prediction of larval survival. Therefore, we assessed wheat stem sawfly survival from early larval growth to the beginning of autumnal diapause in barley cultivars selected from across feed, forage, and two-or six-row malt groups. Field experiments were conducted in Gallatin and Chouteau counties, Montana, in 2016 and 2017. We used Kaplan-Meier estimation to assess larval survival among cultivars. We found that the survival of pre-diapause larvae was greatest in \u27Hockett\u27 (36.5%) and lowest in \u27Celebration\u27 (15.4%). Precipitation and temperature during the growing season affected temporal patterns for larval survival across study sites. Adjusting survivorship curves using site-specific GDD accumulation allowed cultivar-specific survivorship to be estimated more precisely for each site, despite differing environmental influences. Our findings suggest that measuring wheat stem sawfly survival across barley cultivars and standardizing by site-specific GDDs may provide better recommendations on barley cultivars that impede wheat stem sawfly population growth and reduce economic losses
Optics and Quantum Electronics
Contains table of contents on Section 3 and reports on nineteen research projects.Defense Advanced Research Projects Agency Grant F49620-96-0126Joint Services Electronics Program Grant DAAH04-95-1-0038National Science Foundation Grant ECS 94-23737U.S. Air Force - Office of Scientific Research Contract F49620-95-1-0221U.S. Navy - Office of Naval Research Grant N00014-95-1-0715Defense Advanced Research Projects Agency/National Center for Integrated Photonics TechnologyMultidisciplinary Research InitiativeU.S. Air Force - Office of Scientific ResearchNational Science Foundation/MRSECU.S. Navy - Office of Naval Research (MFEL) Contract N00014-91-J-1956National Institutes of Health Grant R01-EY11289U.S. Navy - Office of Naval Research (MFEL) Contract N00014-94-0717Defense Advanced Research Projects Agency Contract N66001-96-C-863
Plant Volatiles and Oviposition Behavior in the Selection of Barley Cultivars by Wheat Stem Sawfly (Hymenoptera: Cephidae)
Wheat stem sawfly, [Cephus cinctus (Hymenoptera: Cephidae)], females display complex behaviors for host selection and oviposition. Susceptible hollow stem wheat (Triticum aestivum L.) cultivars release a greater amount of attractive compound, (Z)-3-hexenyl acetate and receive a greater number of eggs compared to resistant solid stem wheat cultivars. However, barley (Hordeum vulgare L.) is becoming a more common host for C. cinctus in Montana. Therefore, how do host selection and oviposition behaviors on barley cultivars compare to what happens when encountering wheat cultivars? To answer this question, we carried out greenhouse experiments using two barley cultivars: \u27Hockett\u27 and \u27Craft\u27. Between these cultivars at Zadoks stages 34 and 49, we compared host selection decisions using a Y-tube olfactometer, compared oviposition behaviors on stems, and counted the number of eggs inside individual stems. In Y-tube bioassays, we found a greater number of C. cinctus females were attracted to the airstream passing over \u27Hockett\u27 than \u27Craft\u27 barley cultivars. Although the frequencies of oviposition behaviors were similar between these cultivars, the number of eggs was greater in \u27Hockett\u27. Volatile profiles indicated that the amount of linalool was greater in the airstream from \u27Craft\u27 than in \u27Hockett\u27 at Zadoks 34 while the amount of (Z)-3-hexenyl acetate was greater in airstream from \u27Hockett\u27 at both Zadoks 34 and 49. These results suggest that volatiles of barley plants influenced host selection behavior of ovipositing C. cinctus females, while other discriminating behaviors do not differ between cultivars
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